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  HUM-MOLGEN -> Events -> Meetings and Conferences  

Signal Transduction Pathways as therapeutic targets

  October 26, 2005  
LBMCC Hopital Kirchberg, Luxembourg
25 - 28 January 2006

Scientific Program


Wednesday January 25th, 2006

14h00 - 18h00: Keynote session


Gregg L. Semenza (Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, USA):

Keynote: Hypoxia Signal Transduction in Health and Disease


Michael B. Yaffe (Center for Cancer Research, Department of Biology

Massachusetts Institute of Technology, Cambridge, MA, USA):

Phosphoserine/threonine-binding domains: Integrators of protein kinase signaling pathways in cell cycle control and cancer


Mathieu Bollen (Afdeling Biochemie, Faculteit Geneeskunde, Katholieke Universiteit Leuven, Leuven, Belgium):

title to be announced


Jurg Tschopp (Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Epalinges, Switzerland):

Conserved signaling mechanisms in plant and vertebrate innate immunity


Roger J. Davis (Howard Hughes Medical Institute, UMASS Medical School, Worcester, USA):

Signal transduction by stress-activated MAP kinases



Thursday January 26th, 2006 (Morning session)

8h30 - 10h30: Receptor signaling

Richard W. Padgett (Waksman Institute, Rutgers University, Piscataway, USA):

TGFbeta Growth Control


Walter Birchmeier (Max-Delbruck-Center for Molecular Medicine, Berlin, Germany):

The role of Met-Gab1 Signalling in vivo.


Ulf R. Rapp (Institut fuer Medizinische Strahlenkunde und Zellforschung (MSZ), Wuerzburg, Germany):

title to be announced


Johannes L. Bos (Dept of Physiological Chemistry, Utrecht, The Netherlands):

title to be announced


11h00 - 13h00: Protein kinase cascades as therapeutic targets

Dario Alessi (MRC Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB Complex, University of Dundee, Scotland):

title to be announced


Jacques Pouysségur (Institute of Signaling, Developmental Biology and Cancer Research CNRS UMR 6543, Centre A. Lacassagne, Nice, France):

Nutrient stress signaling and tumor progression


Brian Hemmings (Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland):

Human nuclear Dbf2-related kinases (NDRs) are up-regulated in cancer


Laurent Meijer (CNRS, Roscoff, France):

Multiple intracellular effects of pharmacological inhibitors of cyclin-dependent kinases


Ying Xia (Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, USA):

title to be announced



Thursday January 26th, 2006 (Afternoon session)

16h00 - 18h30: Cell death in cancer

Caroline Dive (Cellular and Molecular Pharmacology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom):

title to be announced


Peter H. Krammer (Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany):

Signaling of life and death in T cells


Guido Kroemer (CNRS, UMR8125, Institut Gustave Roussy, Villejuif, France):

Mechanisms of caspase-independent cell death


Gerry Melino (Biochemistry Laboratory, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy):

title to be announced


Sidhartha Ray (Arnold & Marie Schwartz College of Pharmacy & Health Sciences

Div. of Pharmaceutical Scs/Long Island University, Brooklyn, NY, USA):

How Antitoxic and Anticancer signals Maneuver Programmed and Unprogrammed Cell Death In Vivo?


Jean Edouard Dumont (Institut de Recherche Interdisciplinaire (IRIBHM), Universite Libre de Bruxelles (ULB), Belgique):

Molecular Biology of Thyroid Cancer


Friday January 27th, 2006 (Morning  session)

8h30 - 10h30: Inflammation specific signaling

Bharat B. Aggarwal (Cytokine Research Section, The University of Texas M. D. Anderson Cancer Center, Houston, USA):

Targeting Inflammatory Cell signaling pathway for Prevention and Treatment of cancer


Mark Ginsberg (Department of Medicine, University of California San Diego, La Jolla, CA, USA):

Integrin Signaling in Cancer and Inflammation


Moncef Zouali (INSERM U606, Centre Viggo Petersen, Hôpital Lariboisière,

Paris, France):

Signaling pathways in systemic autoimmune diseases: Toward novel opportunities for therapeutic targeting


Irfan Rahman (Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA):

Regulation of inflammation and glucocorticoid signaling by curcumin and resveratrol


Lina Ghibelli (University Tor Vergata, Rome, Italy):

title to be announced


11h00 - 13h00: Cell signaling in health and disease

Bernd Groner (Georg-Speyer-Haus, Institute for Biomedical Research, Frankfurt am Main, Germany):

Signaling events in mammary epithelial cell differentiation and breast cancer


Anna Krichevsky (Center for Neurologic Diseases, Brigham and Women's Hospital

Harvard Medical School, Boston, USA):

A role of microRNAs in brain tumors (preliminary title)


Dominique Stehelin (CNRS UMR 8526, Institut de Biologie de Lille, France):

New steps toward the use of parvovirus H1 as a therapeutic anti-cancer drug.


John Hiscott (Molecular Oncology Group Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada):

TLR-dependent and -independent pathways leading to the interferon antiviral response



Friday January 27th, 2006 (Afternoon session)

16h00 - 18h30: Cell signaling pathways leading to regulated chromatin modifications

Richard Pestell (Lombardi Comprehensive Cancer Center, Georgetown University, Washington, USA):

"Cyclins and cdks": Target for Cancer Therapy


François Fuks (Free University of Brussels, Faculty of Medicine, Laboratory of Molecular Virology, Brussels, Belgium) :

Mechanisms of DNA methylation in mammals


Luciano Di Croce (ICREA and Centre de Regulacio Genomica (CRG), Barcelona, Spain):

title to be announced


Willem Voncken (Research Institute Growth and Development, University Maastricht, The Netherlands):

title to be announced


Guy Haegeman (Laboratory for Eukaryotic Gene Expression and Signal Transduction, Department of Molecular Biology, Ghent University, Belgium):

Chromatin impact on NFkB-driven gene expression



Saturday January 28th, 2006 (Morning session)

8h30 - 10h30: Transcriptional control

Yinon Ben-Neriah (The Lautenberg Center for Immunology, Hebrew-University-Hadassah Medical School, Jerusalem, Israel):

title to be announced


Sankar Ghosh (Yale University School of Medicine, New Haven, CT , USA):

title to be announced


Moshe Oren (Department of Molecular Cell Biology, The Weizmann Institute, Rehovot, Israel):

Oncogenic signaling by mutant p53



11h00 - 13h00: Transcriptional control

Young-Joon Surh (National Research Laboratory of  Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, South Korea):

Redox-Sensitive Transcription Factors as Prime Targets for Chemoprevention and Cyoprotection


Iris Behrman (University of Luxembourg):

title to be announced


Jacques Piette (Laboratory of Virology & Immunology, Institute of Pathology B23, University of Liege, Liege, Belgium):

The posphatase SHIP-1 is an important mediator in the oxidative stress-induced NF-kB activation.


Peter Angel (Deutsches Krebsforschungszentrum, DKFZ, Division of Signal Transduction and Growth Control, Heidelberg, Germany):

Regulation of gene expression in skin remodeling and tumourigenesis


13h00: End of the meeting


Organized by: Marc Diederich
Invited Speakers: Gregg L. Semenza (Baltimore, USA)
Michael B. Yaffe (Cambridge, USA)
Mathieu Bollen (Belgium)
Jurg Tschopp (Epalinges, Switzerland)
Roger J. Davis (Worcester, USA)
Richard W. Padgett (Piscataway, USA)
Walter Birchmeier (Berlin, Germany)
Ulf R. Rapp (Wuerzburg, Germany)
Johannes L. Bos (Utrecht, The Netherlands)
Dario Alessi (Dundee, Scotland)
Jacques Pouysségur (Nice, France)
Brian Hemmings (Basel, Switzerland)
Laurent Meijer (France)
Ying Xia (Cincinnati, USA)
Caroline Dive (Manchester, United Kingdom)
Peter H. Krammer (Heidelberg, Germany)
Guido Kroemer (Villejuif, France)
Gerry Melino (Rome, Italy)
Sidhartha Ray (Brooklyn, USA)
Jean Edouard Dumont (Brussels, Belgium)
Bharat B. Aggarwal (Houston, USA)
Mark Ginsberg (La Jolla, USA)
Moncef Zouali (Paris, France)
Irfan Rahman (Rochester, USA)
Lina Ghibelli (Rome, Italy)
Bernd Groner (Frankfurt am Main, Germany)
Anna Krichevsky (Boston, USA)
Dominique Stéhelin (Lille, France)
John Hiscott (Montreal, Canada)
Richard Pestell (Washington, USA)
François Fuks (Brussels, Belgium)
Luciano Di Croce (Barcelona, Spain)
Willem Voncken (Maastricht, The Netherlands)
Guy Haegeman (Ghent, Belgium)
Yinon Ben-Neriah (Jerusalem, Israel)
Sankar Ghosh (New Haven, USA)
Moshe Oren (Rehovot, Israel)
Young-Joon Surh (Seoul, South Korea)
Iris Behrman (University of Luxembourg)
Jacques Piette (Liege, Belgium)
Peter Angel (Heidelberg, Germany)
Deadline for Abstracts: 31 December 2005
Registration: please use oline registration at : http://www.transduction-meeting.lu
E-mail: marc.diederich@lbmcc.lu
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