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Beilstein-Institut, Ruedesheim/Rhein
2006-08-17
The post-genomic era is significantly characterized by a high integration and interdisciplinary of research resources from such diverse fields as computational biology, bioinformatics, functional genomics, structural biology, and proteomics. In this perspective, established biological systems can be comprehensivley investigated in terms of interactions of individual or groups of proteins and enzymes as well as the behaviour of collective networks of such interactions. On the other hand, these systems can be re-examined in the light of new results that suggest novel associations between otherwise unrelated pathways and individual proteins.
Modern experimental technologies are providing seemingly endless opportunities to generate massive amounts of sequence, expression and functional data. Continuous advances and improvements have enabled proteome analyses to proceed with increased depth and efficiency.
To capitalize on this enormous pool of information and in order to understand fundamental biological phenomena it is essential to collect, organize, categorize, analyze, and share data and results.
However, whilst the large international genome sequencing projects elicited considerable public attention with the creation of huge sequence databases, it has become increasingly apparent that functional data for the gene products, in particular for enzymes, has either limited accessibility or is unavailable. Additionally, although enzyme structural information has been rapidly accumulated in databases, little effort has been invested toward systematic characterization of enzyme functions.
The problem is twofold; deriving data from experimental work is expensive and very time consuming and it is inherently very difficult to collect, interpret and standardize published data since they are widely distributed among journals covering a number of fields, and the data itself is often dependent on the experimental conditions.
For these reasons a systematic and standardized collection of functional enzyme data is essential for the interpretation of the genome information.
The first ESCEC meeting in 2003 resulted in a general agreement that standardization of experiments and methods for enzyme characterization is definitely necessary and in the formation of the STRENDA commission.
STRENDA stands for Standards for Reporting Enzyme Data and the commission will be in attendance at the forthcoming series of ESCEC symposia.
This symposium will provide a platform for discussing a number of checklists drawn up and presented by the STRENDA commission. These lists are intended to support the improvement of reporting enzyme data. The result of these discussions may lead to the adoption of presented and discussed lists and to an agreement that these should be recommended for use in future publications. The recommendations can then be presented to the scientific community in a published form. Further aims are to collect ideas on organism-related definitions of experimental conditions and to discuss the demands of systems biology on the quality of data to be considered for the preparation of further checklists by the commission.
Finally, the symposium will provide an occasion to share STRENDA's experiences with other standardization initiatives with the medium-term aim of creating a joint standardization movement.
The workshop will take place in the historic Hotel Jagdschloss Niederwald in Ruedesheim/Germany. The setting and the limited number of participants (ca. 50-60), provide a very convivial atmosphere for the ready exchange of thoughts and ideas.
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Organized by:
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Beilstein-Institut and STRENDA Commission |
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Invited Speakers:
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Robert Alberty, MIT, Cambridge, MA, USA
Athel Cornish-Bowden, CNRS-BIP, Marseille, France
Valérie de Crécy-Lagard, University of Florida, Gainesville, FL, USA
Kirill Degtyarenko, EBI, Cambridge, UK
Oleg Demin, MSU, Moscow, Russia
Mike Ellison, University of Alberta, Edmonton, Alberta, CA
Martin Field, CEA/CNRS, Grenoble, France
Jannie Hofmeyr, University of Stellenbosch, South Africa
Hermann-Georg Holzhuetter, Charité-Humboldt-University, Berlin, Germany
Minoru Kanehisa, University of Kyoto, Japan
Ursula Klingmueller, German Cancer Research Center, Heidelberg, Germany
Ursula Kummer, EML Research gGmbH, Heidelberg, Germany
Nicolas LeNovere, EBI, Cambridge, UK
Thomas Leyh, Albert Einstein College of Medicine, Bronx, NY, USA
Klaus Mauch, INSILICO Biotechnology GmbH, Stuttgart, Germany
Steffen Neumann, IPB, Halle, Germany
Scott Pegg, University of California, San Francisco, CA, USA
Isabel Rojas-Muijca, EML Research gGmbH Heidelberg, Germany
Susanna Sansone, EBI, Cambridge, UK
Vincent Schachter, Genoscope-CNS, Evry, France
Hartmut Schlueter, Charite-Humboldt-University, Berlin, Germany
Dietmar Schomburg, University of Cologne, Germany
Jacky Snoep, University of Stellenbosch, South Africa
Keith Tipton, Trinity College, Dublin, Ireland
Jan-Olof Winberg, University of Tromso, Norway
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Deadline for Abstracts:
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2006-01-20
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Registration:
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see www.strenda.org/escec2.html
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E-mail:
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ckettner@beilstein-institut.de
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