Complex Trait Consortium 2004

9:00 am, “In silico mapping-the possibilities and the problems”
Tim Wiltshire, Ph.D., Genomics Inst. Of the Novartis Foundation

9:30 am, “Genetic and haplotype diversity in wild derived mouse inbred strains”
Fernando Pardo-Manuel de Villena, Ph.D., University of NC School of Medicine

10:00 am, “Applications of the ancestral haplotype patterns in classical inbred strains”
Mark Daly, Ph.D., Whitehead Institute

Session II: Research Resources and Demos (Roving Session) (Chair, Molly Bogue, The Jackson Laboratory)
11:00 am, “Mouse Phenome Database and other Resources”
Molly Bogue, Ph.D., The Jackson Laboratory

Session III: Strategies for Finding Quantitative Trait Genes (Chair, Robert Hitzemann, Oregon Health Sciences University)
11:30 am, “From QTL to QTG: Are we getting closer?”
Ariel Darvasi, Ph.D., The Hebrew University of Jerusalem

12:00 pm, “Finding QTL genes with integrative genomics”
Beverly Paigen, Ph.D., The Jackson Laboratory

1:30 pm, “The genetics of genome-wide gene expression”
John Belknap, Ph.D., Portland VA Medical Center

2:00 pm, “The multicross mapping approach to neuropharmacological and behavioral phenotypes”
Robert Hitzeman, Ph.D., Oregon Health Sciences University

2:30 pm, “Efficacy of collaborative cross-based recombinant inbred lines for fine-mapping small effect QTLs”
William Valdar, Ph.D., Wellcome Trust Centre for Human Genetics

3:00 pm, “QTL reaper: QTL detection with microarray data.”
Ken Manly, Ph.D., Roswell Park Cancer Institute

Session IV: Gene-Environment Interactions (Chair, William Dietrich, Harvard Medical School)
4:00 pm, “Model systems for pharmacogenomic discovery”
James Watters, Ph.D., Washington University of School of Medicine

4:30 pm, “A QTL analysis of iron storage physiology”
Angel Custodio, Ph.D., Children's Hospital Boston

5:00 pm, “Genetic control of Listeria monocytogenes infection”
Victor Boyartchuk, Ph.D., University of Massachusetts Med School

5:30 pm, “Genetic analysis of innate immunity to infection”
William Dietrich, Ph.D., Harvard Medical School

6:00 pm, Reception and poster session

Thursday, July 8th

Session V: Systems Biology and Complex Traits (Chair, Joe Nadeau, Case Western Reserve University)
8:30 am, “Mixed up mice: Genetic tools for mammalian systems biology”
Gary Churchill, Ph.D., The Jackson Laboratory

9:00 am, “Transcriptional and metabolic profiling of homocysteine homeostasis after diet-induced perturbations in genetically distinct inbred strains of mice”
Toshimori Kitami, Ph.D., Case Western Reserve University

9:30 am, “Systems analysis of bone fragility”
Karl Jepsen, Ph.D., Mount Sinai School of Medicine

10:00 am, TBA
Joseph Nadeau, Ph.D., Case Western Reserve University

11:00 am, “Identifying the key drivers of complex traits through the reconstruction of gene networks using gene expression data from segregating mouse populations”
Eric Schadt, Ph.D., Rosetta Inpharmatics

11:30 am, “Combinatorial approaches to the identification of transcriptional regulatory networks using microarray, comparative genomic cis-element analyses, and QTL modifier data”
Bruce Aronow, Ph.D., University of Cincinnati

12:00 pm, “The mouse genome as a framework for complex trait analysis”
Carol Bult, Ph.D., The Jackson Laboratory

Session VI: Statistical Analysis Methods (Chair, Gary Churchill, The Jackson Laboratory)
1:30 pm, “Statistical issues in QTL mapping in recombinant inbred lines”
Karl Broman, Ph.D., Johns Hopkins University

2:00 pm, “Graphical diagnostics for multiple QTL investigation”
Brian Yandell, Ph.D., University of Wisconsin-Madison

2:30 pm, “Bayesian model selection for mapping complex epistatic quantitative trait loci in experimental designs”
Nengjun Yi, Ph.D., University of Alabama, Birmingham

3:00 pm, “GenSimXP: an R package for the simulation and analysis of complex traits in experimental populations”
Daniel Gaile, Ph.D., Texas A & M University

3:30 pm, Refreshments, Posters and Computer Demos

Friday, July 9th

Session VII Detecting and mapping cancer modifier genes (Chair, Kent Hunter, National Cancer Institute)
8:30 am, “Genetic and environmental factors contributing to colorectal cancer susceptibility”
David Threadgill, Ph.D., University of North Carolina at Chapel Hill

9:00 am, “Epigenetic modifiers of susceptibility to astrocytoma”
Karlyne Reilly, Ph.D., NCI at Fredrick

9:30 am, “Identification of Ter, a modifier of germ cell tumor incidence in male mice”
Angabin Matin, Ph.D., UT M. D. Anderson Cancer Center

10:30 am, “Petr1 (p16, Cdkn2b) and Petr2 (mTOR, Frap) encode efficiency alleles that act additively to suppress plasmacytomagenesis”
Beverly Mock, Ph.D., CCR, NCI

11:00 am , “Using multi-omic technologies to gain insights into mammary tumor metastasis efficiency”
Kent Hunter, Ph.D., National Cancer Institute

11:30 am, Posters and Computer Demos (open through afternoon)

Session VIII: Strategies in studying complex Traits: a moderated open forum (Chair, Robert Williams, Ph.D., University of Tennessee)

2:00 pm, Objective: to discuss approaches to complex trait analysis using real test datasets submitted by meeting participants

Session IX: Round Table Discussion: challenges, goals, outreach, funding strategies
(David Threadgill, Ph.D., University of North Carolina at Chapel Hill, Moderator)

4:00 pm, Objective: to identify challenges/roadblocks to complex trait analysis and to formulate group strategies for the near term, particularly with respect to funding paradigms and the development and optimization of new and existing community research resources.

End of Meeting