Fondation Mérieux, Veyrier du Lac, near Annecy (French Alps)
21-24 March 2004
INTERNATIONAL SYMPOSIUM ON:PLANT-DERIVED VACCINES AND ANTIBODIES: POTENTIAL AND LIMITATIONS
21-24 March 2004
Organized by the Fondation Mérieux
in partnership with Aventis Pasteur
PROVISIONAL PROGRAM
(version 3 December 2003)
As the conference date approaches, updated versions of the program will be posted directly on our website (http://www.fond-merieux.org).
Les Pensières
Veyrier du Lac, near Annecy (French Alps)
Scientific Committee
Stanley Plotkin (University of Pennsylvania, Philadelphia)
Charles Arntzen (Arizona State University), Rose Hammond (USDA-ARS, Beltsville), Alexander V. Karasev (Thomas Jefferson University, Philadelphia), Hilary Koprowski (Thomas Jefferson University, Philadelphia), Tikki Pang (WHO, Geneva), Michael W. Russell (University of Buffalo), Regis Sodoyer (AvP, Lyon), Betty Dodet (Fondation Mérieux, Lyon)
Objectives: To review the state of research and applications (in human and veterinary medicine) of antigen and antibody production in plants, evaluate the prospects and limitations of this approach, and propose steps forward. This meeting seeks to bring together researchers, clinicians, and representatives of industry and regulatory agencies from developed and developing countries.
SUNDAY 21 MARCH 2004
17:00 Registration
OPENING SESSION Welcome address
17:45-18:15 Keynote lectureCharles J. ARNTZEN, Arizona State University, Tempe, USA
18:15-18:45 Keynote lectureHilary KOPROWSKI, Jefferson University, Philadelphia, USA
19:30 Dinner MONDAY 22 MARCH SESSION I.- EXPRESSION OF FOREIGN PROTEINS IN PLANTS
Chairperson: William O. DAWSON, University of Florida, Lake Alfred, USA
Transgenic plants
09:00 Opportunities for recombinant antigen and antibody expression in transgenic plants; technology assessmentStefan SCHILLBERG, Fraunhofer Institute for Molecular Biology, Aachen, Germany
09:20 Questions and answers 09:25 Post-translational processing in plants (including glycosylation)Loïc FAYE, CNRS/University of Rouen, France
09:45 Questions and answers
09:50 Chloroplast genetic engineering for vaccine productionHenry DANIELL, University of Central Florida, Orlando, USA
10:10 Questions and answers
Viral vectors
10:15 Viral vectors for plant transgenesisPaul AHLQUIST, University of Winsconsin, Madison, USA
10:35 Questions and answers
10:40 Break
11:10 Viral vectors for antigen/antibody gene transfection in plantsGeorge LOMONOSSOFF, John Innes Centre, Norwich, United Kingdom
11:30 Questions and answers
11:35 Discussion: What criteria should be used to select the plant species used for vaccine and antibody production? Are there special needs in the developing world?
12:05 Lunch
SESSION II.- MUCOSAL IMMUNIZATION
INDUCTION OF IMMUNITY / TOLERANCE / ALLERGY BY ORAL ANTIGENS Chairperson: Michael W. RUSSELL, University of Buffalo, USA 13:30 Uptake and presentation of orally administered antigensMaria RESCIGNO, European Institute of Oncology, Milan, Italy
13:50 Questions and answers
13:55 Immune responses to orally administered antigensAllan M. MOWAT, University of Glasgow, UK
14:15 Questions and answers
14:20 Mechanisms of tolerance induction to orally administered antigensJiri MESTECKY, University of Alabama at Birmingham, USA
14:40 Questions and answers
14:45 Mucosal adjuvants John D. CLEMENTS, Tulane University School of Medicine, New Orleans, USA
15:05 Questions and answers
15:10 General discussion
15:40 Break
SESSION III.- PLANT-DERIVED ANTIBODIES
Chairperson: Hilary KOPROWSKI, Jefferson University, Philadelphia, USA
16:10 Antibody engineering and new strategies for their production, including HIV prevention and therapyJulian MA, Guy’s Hospital, London, United Kingdom
16:30 Questions and answers
16:35 Plant-derived antibodies for contraception and prevention of sexually transmitted diseases in humansKevin WHALEY, Johns Hopkins University, Baltimore, USA
16:55 Questions and answers
17:00 Expression of single chain antibodies in transgenic plantsPatricia GALEFFI, ENEA, Roma, Italy
17:20 Questions and answers
17:25 Production of human antibodies in eukaryotic algaeSteven MAYFIELD, The Scripps Research Institute, La Jolla, USA
17:45 Questions and answers
17:50 Hepatitis B antibody production in tobacco plants as an example of an integrated plantibody production systemCarlos BORROTO, Center for Genetic Engineering and Biotechnology, Habana
18:10 Questions and answers
18:15 Discussion
18:45 Poster session and cocktail
19:30 Dinner
TUESDAY 23 MARCH 2004
SESSION IV.- PLANT-DERIVED CANDIDATE VACCINES
Part A: Veterinary vaccines
Chairperson: Rose HAMMOND, USDA-ARS, Beltsville, USA 08:45 Production of foot-and-mouth disease vaccines in plantsAndres WIGDOROVITZ, Institute of Agricultural Technology, Argentina
09:05 Questions and answers
09:10 Production of poultry vaccines in plantsSteve R. WEBB, Dow Agrosciences, USA
09:30 Questions and answers
09:35 Conservation biology using immunocontraceptive vaccines to control feral animal populationsIan POLKINGHORNE, Institute for Molecular Biosciences, Queensland, Australia
09:55 Questions and answers
10:00 Plant-derived vaccines for immunization against classical swine fever virus (CSFV) and F. hepatica Andrzej B. LEGOCKI, Polish Academy of Sciences, Poznan, Poland
10:20 Questions and answers
10:25 Discussion: Prospects and impact of plant-derived vaccines for animals
10:45 Break Part B: Human vaccines Chairperson: Stanley PLOTKIN, University of Philadelphia, USA 11:15 Virus-like particle expression and assembly in plants( with hepatitis B vaccine example)Hugh MASON, Arizona State University, Tempe, USA
11:35 Questions and answers 11:40 Progress towards a plant-derived measles vaccineSteve L. WESSELINGH, Macfarlane Burnet Institute, Melbourne, Australia
12:00 Questions and answers
12:05 Plant-derived vaccines against diarrheal diseases Carol TACKET, Center for Vaccine Development, University of Maryland, Baltimore, USA
12:25 Questions and answers
12:30 Lunch
14:00 Progress towards a plant-derived rotavirus vaccineWilliam LANGRIDGE, Center for Molecular Biology and Gene Therapy, Loma Linda University, USA
14:20 Questions and answers
14:25 Challenges in creating a vaccine to prevent hepatitis ENaokazu TAKEDA, National Institute of Infectious Diseases, Tokyo, Japan
14:45 Questions and answers
14:50 HIV and anthrax vaccines produced in plantsAlexander V. KARASEV, Thomas Jefferson University, Philadelphia, USA
15:10 Questions and answers
15:15 Human papilloma virus vaccine produced in plantsMartin MÜLLER, German Cancer Research, Heidelberg, Germany
15:35 Questions and answers
15:40 General discussion on vaccine production in plantscoordinated by Rose HAMMOND and Stanley PLOTKIN
16:00 Break
SESSION V.- COMMERCIAL DEVELOPMENT OF PRODUCTION IN PLANTS
Chairperson: Charles ARNTZEN, Arizona State University, Tempe, USA
16:30 Presentations by selected companies
17:30 Poster session
19:30 Dinner
WEDNESDAY 24 MARCH 2004
SESSION V (CONTINUED).- COMMERCIAL DEVELOPMENTS Chairperson: Charles ARNTZEN, Arizona State University, Tempe, USA
08:30 Presentations by selected companiesDiscussion
SESSION VI.- PUBLIC HEALTH PERSPECTIVES,
REGULATORY CONSIDERATIONS AND ENVIRONMENTAL ISSUES
Chairperson: Tikki PANG, WHO, Geneva, Switzerland 09:30 Environmental and political considerations concerning release of genetically modified cropsChen ZHANGLIANG*, Beijing University, China
09:50 Questions and answers
09:55 Ethics guidelines for the introduction of plant-derived vaccines in developing countriesDavid CASTLE, University of Guelph, Canada
10:15 Questions and answers
10:20 Break
10:45 Round-table 1, on Public Health, chaired by Tikki PANG, WHO, Geneva,Switzerland,Richard JEFFERSON, Center for Application of Molecular Biology to International Agriculture, Cambia, Australia; Regina RABINOVICH, Gates Foundation, Seattle, USA; Rachel CHIKWAMBA, Iowa State University, Ames, USA; Richard MAHONEY, Arizona State University, Tempe, USA; Varaprasada REDDY*, Shanta Biotech, India
12:15 Lunch
Chairperson: Marie-Paule KIENY, WHO, Geneva
13:45 What is the advantage of plant-derived antibodies from the pharmaceutical industry perspective? Gordon MOORE, Centocor, Malvern, USA
14:05 Questions and answers
14:10 Round-table 2, on Regulatory Issues, chaired by Marie-Paule Kieny, WHO, GenevaCarlos BORROTO, Centre for Genetic Engineering and Biotechnology, Habana, Cuba; Chen ZHANGLIANG*, Beijing University, China; Kiran K. SHARMA*, International Institute for Research on Agriculture in Arid Climates, Patancheru, India, Jon DAUGHERTY, FDA-CBER,Rockville, USA, Representatives of: USDA-APHIS; John PURVES, EMEA (Europe)
15:30 Potential and limitations of vaccine and antibody production in plants. What are the most productive directions?Roger BEACHY, Donald Danford Plant Science Center, Saint Louis, USA
15:50 Discussion/Conclusion
16:00 End of meeting
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