Recherches Scientifiques Luxembourg (RSL), Luxembourg
25 - 28 January 2004
Signal transduction pathways as therapeutic targets
(January 25th - January 28th, 2004)Sunday, January, 25th, 2004 (Afternoon)
Keynote session :
19h00 - 20h00 : Sara Courtneidge (Grand Rapids, USA) : Scr family kinase in cellular signal transduction pathways
Monday, January, 26th, 2004 (Morning)
Session I: Protein kinases as targets for novel treatments
8h30 - 9h00 : Roger Davis (Worcester, USA) : TARGETING JNK FOR THERAPEUTIC BENEFIT
9h00 - 9h30 : Roy Golsteyn (Roscoff, France) : Pharmacological inhibitors of cyclin-dependent kinases (CDKs)
9h30 - 10h00 : Jacques Pousségyur (Nice, France) : Tumor angiogenesis and nutritional-sensing mechanisms
10h00 - 11h00 : Coffee break 11h00 - 11h30 : Ying Xia (Cincinnati, USA) : Eye development and signaling through MEKK1
11h30 - 12h30 : free presentations
Monday, January, 26th, 2004 (Afternoon)
Session II: Angiogenesis
16h00 - 16h30 : Andreas Bikfalvi (Bordeaux, France) : New molecules,strategies and models to inhibit tumor angiogenesis and growth
16h30 - 17h00 : Raghu Kalluri (Boston, USA) : Physiological levels of tumstatin, a fragment of collagen IV ?3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via ?V?3 integrin
17h30 - 18h00 : Randolph Watnick (Cambridge, USA) : Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis
18h00 - 19h00 : free presentations
Tuesday, January, 27th (Morning)
Session III: Apoptosis
8h30 - 9h00 : Craig Thompson (Philadelphia, USA) : The proto-oncogenes AKT and Pim-2 are components of redundant signalling pathways that suppress apoptosis.
9h00 - 9h30 : Paul Clarke (Dundee, UK) : Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
9h30 - 10h00 : D. Lambrechts (Leuven, Belgium) : VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death 10h00 - 11h00 : Coffee break 11h00 -11h30 : Jo Trapani (Melburne, Australia) : Results indicate the importance of the mitochondrial pathway in granzyme-B-mediated cell death.
11h30-12h00 : Jean-Laurent Casanova (Paris, France) : The main Toll-like receptor signal-transduction pathway in humans is not essential for survival and has a much narrower role than expected
12h00 - 12h30 : Kaspar Hoebe (La Jolla, USA) : Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
Tuesday, January, 27th (Afternoon)
Session IV : Cancer specific signaling pathways as therapeutic targets
16h00 - 16h30 : Dean Felsher (Stanford, USA) : Cancer revoked: oncogenes as therapeutic targets.
16h30 - 17h00 : Evan Keller (Ann Arbor, USA) : RAF kinase inhibitor protein (RKIP) suppresses prostate cancer metastasis.
17h00 - 17h30 : John Benson (Cambridge, USA) : Targeting of proteins to membranes through hedgehog auto-processing
17h30 - 18h00 : Neil Watkins (Baltimore, USA) : Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
18h00 - 18h30 : Stefano Piccolo (Padoa, Italy) : Convergence of the p53 and Smad signaling networks
18h30 - 19h00 : Jong-Wan Park (Seoul, Korea) : YC-1: A Potential Anticancer Drug Targeting Hypoxia-Inducible Factor 1
Wednesday, January 28th, 2004 (Morning)
Session V: Chemopreventive agents
8h30 - 9h00 : Bharat Aggarwal (Houston, USA) : Chemopreventive agents as therapeutic agents
9h00 - 9h30 : Young-Joon Surh (Seoul, Korea) : Intracellular Signaling Molecules as Prime Targets for Chemopreventive Phytochemicals
9h30 - 10h00 : Marc Diederich (Luxembourg, Luxembourg) : Effects of chemopreventive agents on stress and drug resistance genes
10h00 - 11h00 : Coffee break 11h00 - 11h30 : Ho-Young Lee (Houston, USA) : Effects of Deguelin on the Phosphatidylinositol 3-Kinase/Akt Pathway and Apoptosis in Premalignant Human Bronchial Epithelial Cells 11h30-12h30 : free presentations
Session VI : siRNA and gene regulation
(Session organizer : Ch. Branlant, Nancy, France)
14h00 - 17h00 : program to be announced
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