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  Cambridge Healthtech Institute's Molecular Display  
  January 28, 2003

Biotechnology

 
     
  Cambridge Healthtech Institute, Hyatt Regency Cambridge, 575 Memorial Drive, Cambridge, MA 02139
May 12-13, 2003


NEW TECHNOLOGIES AND TARGET SELECTION
Cell-Based Systems for Protein Engineering
High-Diversity Libraries for Rapid Protein Optimization
Monobodies: Small Antibody Mimics
Phage-Based Electronic and Magnetic Materials

USE OF PHAGE DISPLAY TO DISCOVER SMALL MOLECULES
Mapping Small Molecule Binding Sites with Phage Display
Synthetic Compound Libraries Displayed on Bacteriophages
DNA-Encoded Small Molecules and Molecular Evolution
Novel Lead Molecules through in Vivo Phage Display

APPLICATIONS IN PROTEOMICS
A Genetic Assay for Protein Evolution and Proteomics
Decoding Protein Kinase Signaling Networks
Drug Receptor Identification Using mRNA Display
Novel, High-Affinity Tumor Imaging Agents
Cancer Diagnostics Using Microarrays of Phage-Displayed Tumor Antigens
Mapping Molecular Diversity of Blood Vessels by in Vivo Phage Display

APPLICATION IN NOVEL THERAPEUTICS AND DIAGNOSTICS
Use of Phage Display to Identify Antibodies with Exquisite Target Specificity
Mapping Binding Energetics with Statistical Analysis of Combinatorial Libraries
Regulatable Therapeutics: Aptamer-Antidote Pairs
A Novel and Versatile Platform for Antibody Display and Engineering via Heterodimerization

POST-CONFERENCE TUTORIAL
Comparison of Display Technologies for Making Therapeutic Antibodies
Dr. James D. Marks, University of California, San Francisco

Phage display of peptide and protein libraries is a powerful tool for identifying compounds that recognize and bind to targets that have been identified. These repertoires of proteins and peptides include enzymes and antibodies, which have interest as drug targets. Phage systems are used for the detection of protein-ligand interactions and for improving binding affinities. The diversity of display methodologies that exist (ribosome, yeast, phage, bacterial, antibody) offers a variety of capabilities in panning for affinity interactions. Alternative display systems offer the opportunity to address issues of expression biases that exist with phage display and to explore the possibility of creating compounds of small molecular weight, greater diversity, and druglike properties. Phage display can be used to identify biomarkers of disease in prostate cancer, cardiovascular disease, and angiogenesis. The peptides are capable of homing to specific pathways and targets within those pathways. By generating the proteins expressed from cDNA libraries, display methodologies can provide a direct link between phenotype and genotype.

 
 
Organized by: Cambridge Healthtech Institute
Invited Speakers: Dr. Robert F. Balint, KaloBios, Inc.
Dr. Angela Belcher, Massachusetts Institute of Technology
Mr. Steven E. Cwirla, XenoPort Inc.
Dr. Sven Klussmann, NOXXON Pharma AG
Dr. Shohei Koide, The University of Chicago
Dr. Elias Lazarides, Targeted Molecules Corporation (TMC)
Mr. Hening Lin, Columbia University
Dr. Lee Makowski, Argonne National Laboratory
Dr. Michael McPherson, Phylos, Inc.
Dr. Renata Pasqualini, M.D. Anderson Cancer Center, University of Texas
Dr. Edward F. Patz, Jr., Duke University Medical Center
Dr. Henrik Pedersen, Nuevolution A/S, Denmark
Dr. Christopher P. Rusconi, Duke University Medical Center
Dr. Aaron Sato, Dyax Corp.
Dr. Sachdev Sidhu, Genentech Inc.
Dr. Merilyn Sleigh, Evogenix Pty Ltd.
Dr. Michael A. Tainsky, Wayne State University
Dr. Michael B. Yaffe, Massachusetts Institute of Technology
Dr. Ping Zhong, Abmaxis Inc.

PRE-CONFERENCE TUTORIAL
Display Technologies, Library Construction, and Screening
Dr. Jamie Scott, Simon Fraser University

 
Deadline for Abstracts: April 4, 2003
 
Registration: Available Online Call: 617-630-1300/Fax: 617-630-1325 e-mail: chi@healthtech.com
E-mail: eeskedal@healthtech.com
 
  Posted by:   elaine eskedal  
Host: wks152.healthtech.com
   
 
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