HUM-MOLGEN events: CHI's GENE QUANTIFICATION

HUM-MOLGEN -> Events -> Meetings and Conferences

September 21, 2001

Cambridge Healthtech Institute, Hilton San Diego Resort
February 11-12, 2002

In the early 1990s it was believed that combinatorial chemistry would revolutionize the drug discovery industry. Ten years later the route from design and synthesis of compound libraries to identification of lead structures is still long and costly. Synthesis of an almost unlimited number of organic compounds covering as much of chemistry space as possible is no longer the most cost-effective and time-saving approach to hit identification. Creating libraries by using biological target structure to inform chemical design, facilitated by quantum advances in structural genomics and computational capabilities, is a smarter, more efficient way to produce good initial leads. Considering solubility, permeability, and other druglike properties early in library design and introducing both target and lead structural constraints in lead development are further ways to ensure that more compounds make it to trial. Anyone interested in learning how to develop more effective libraries faster and cheaper, as well as learning from case studies where informed design in conjunction with novel assay development has been successful, should attend this meeting.

Organized by:

Cambridge Healthtech Institute

Invited Speakers:

Technology Approaches
Dual-FRET Molecular Beacons for Gene Detection: The Structure-Function Relationships
Dr. Gang Bao, Georgia Institute of Technology
Protein Quantification from Complex Protein Mixtures Using a Proteomics Methodology with Single-Cell Resolution
Dr. Mark Greene, University of Pennsylvania
TALEST-Tandem Array Ligation of Expressed Sequence Tags: A Novel Method for Generating Global Gene Expression Libraries
Dr. Dom Spinella, Chugai Pharmaceuticals
Novel DNA Amplification Technology: Ramification Amplification (RAM)
Dr. David Zhang, Mount Sinai School of Medicine

Applications
Multiplex Quantitative DNA Array-Based PCR: Quantification of Genetically Modified Maize in Foods
Dr. Knut Rudi, Norwegian Food Research Institute
Cells-to-cDNA™: Reverse Transcription Directly on Cell Lysates
Dr. Brittan Pasloske, Ambion, Inc.
Gene Expression Changes as Radiation-Responsive Molecular Biomarkers for Human Biological Dosimetry
Dr. Marcy Grace, Armed Forces Radiobiology Research Institute

SNPS, Genotyping, and Genetic Variation
A New Simple and Robust Technology for SNP Genotyping
Dr. Avi Reinhartz, Gamida-Sense Diagnostics Ltd.
Identification of Multiple Needles-in-a-Haystack: Mutation Scanning at Extremely High Selectivities
Dr. Mike Makrigiorgos, Dana-Farber Cancer Institute and Harvard Medical School
MegaType Technology for High-Throughput Genomewide Scanning and Discovery of Trait/Disease-Associated SNPs
Dr. Rongdian Fu, Lynx Therapeutics, Inc.

Calibrations, Comparisons and Knowledge
Absolute RNA Quantification
Dr. Stephen Bustin, Queen Mary University of London
A New Mathematical Model for Relative Quantification in Real-Time RT-PCR
Dr. Michael Pfaffl, Technical University of Munich
Comparing Statistical Tests for SAGE Experiments
Dr. Michael Man, Pfizer Global Research
Gene Expression Knowledge
Dr. Rudolph Spangler, Rockefeller University

Deadline for Abstracts:

January 11, 2001

Registration:

http://www.chidb.com/2002/qga/qga_form.htm

E-mail:

fvargus@healthtech.com Frederick Vargus

Posted by:

Frederick Vargus

Host:

wks253.healthtech.com