HUM-MOLGEN events: Mucolipin, TRPs and Human Disease

HUM-MOLGEN -> Events -> Meetings and Conferences

August 08, 2001

National Institutes of Health/ML4 Foundation, Neuroscience Conference Center/National Institutes of Health
9-8-01 - 9-10-01

Mucolipin, TRPs and Human Disease
September 8-10, 2001
Neuroscience Conference Center, National Institutes of Health

For Registration Information: www.ml4.org
Click "What's New" for registration

PROGRAM

Saturday, September 8, 2001

3:00 - 6:00 PM Arrival and Registration, Bethesda Marriott Suites

6:00 - 6:30 PM Opening Reception, Bethesda Marriott Suites

6:30 - 8:30 PM Dinner, Bethesda Marriott Suites
Guest Speaker: Dr. James F. Gusella, Harvard Medical School/Massachusetts General Hospital

Sunday, September 9, 2001

7:00 - 8:00 AM Registration and Breakfast, Bethesda Marriott Suites

8:00 AM Busses depart for Neuroscience Center

8:30 AM - 8:40 AM Welcome
Susan A. Slaugenhaupt
Giovanna Spinella, NINDS, NIH
Randy Yudenfriend Glaser, President, ML4 Foundation

Introduction - 'The TRP Superfamily'

8:40 - 9:10 AM Craig Montell, Johns Hopkins University School of Medicine

Session I - Mucolipidosis Type IV: Clinical Overview
(Moderator, Susan Slaugenhaupt)

9:10 - 9:30 AM Raphael Schiffmann, National Institute of Neurological Disorders and Stroke 'The clinical characteristics of MLIV'

9:30 - 9:50 AM Janine Smith, National Eye Institute
'The ophthalmic manifestations of MLIV'

9:50 - 10:10 AM Edwin Kolodny, New York University School of Medicine
'MLIV mutation screening in the Ashkenazi Jews'

10:10 - 10:30 AM Discussion and Break

Session II - Mucolipidosis Type IV: Gene Cloning and Characterization
(Moderator, Raphael Schiffmann)

10:30 - 10:50 AM Susan Slaugenhaupt, Harvard Medical School/Massachusetts General Hospital 'The MCOLN gene family'

10:50 - 11:10 AM Ehud Goldin, National Institute of Neurological Disorders and Stroke
'The role of Mucolipin in MLIV'

11:10 - 11:30 AM Gideon Bach, Hadassah University Hospital, Israel
'The endocytosis defect in MLIV'

11:30 - 11:50 AM Giuseppe Borsani, TIGEM, Italy
'Understanding the molecular basis of MLIV'

11:50 - 12:10 PM Mei Sun, National Institute of Neurological Disorders and Stroke
'Subcellular localization and trafficking of mucolipin'

12:10 - 12:30 PM Discussion of Morning Sessions

12:30 - 1:30 PM Lunch at Neuroscience Center

Session III - C. elegans models of MLIV

1:30 - 1:50 PM Hanna Fares, University of Arizona
'Regulation of endocytosis by CUP-5'

Session IV - Physiological Roles of TRP Channels (Moderator, Craig Montell)

1:50 - 2:10 PM Baruch Minke, The Hebrew University/Hadassah Medical School
'In vivo studies of TRP gating in Drosophila photoreceptor cells'

2:10 - 2:30 PM Viet Flockerzi, Universitat des Saarlandes, Germany
'TRP-related gene products and human cancer'

2:30 - 2:50 PM Melissa Jungnickel, Florman Lab, University of Massachusetts Medical School
'The Role of Trp2 in Fertilisation'

2:50 - 3:10 PM Indu Ambudkar, National Institute of Dental and Craniofacial Research
'The role of TRP1 in store-operated calcium entry

2:10 - 3:30 PM Discussion and Break

Session IV - Activation Mechanisms of TRP Channels (Moderator, Viet Flockerzi)

3:30 - 3:50 PM Michael Zhu, Ohio State University
'Regulation of TRP proteins by IP3 receptors and Ca2+/calmodulin

3:50 - 4:10 PM Shmuel Muallem, University of Texas Southwestern Medical Center
'Gating of TRP channels by the calcium release channels'

4:10 - 4:30 PM Hong-Tao Ma, Gill Lab, University of Maryland
'Coupling to Activate Store-Operated Channels'

4:30 - 4:50 PM James Putney, National Institute of Environmental Health Sciences
'TRP channels and capacitative calcium entry'

4:50 - 5:10 PM Reinhold Penner, University of Hawaii
'What a long strange TRP it's been'

5:10 - 5:30 PM Discussion of afternoon sessions

5:30 PM Busses depart for Bethesda Marriott Suites

7:00 PM Dinner at Bethesda Marriott Suites

Monday, September 10, 2001

7:00 - 8:00 AM Breakfast

8:00 AM Busses Depart for Neuroscience Center

Introduction to session V and VI - 'The molecular basis of Autosomal Dominant Polycystic Kidney Disease'

8:30 - 9:00 AM Jing Zhou, Harvard Medical School/Brigham and Women's Hospital

Session V - Function and regulation of polycystin 2 (Moderator, Greg Germino)

9:00 - 9:20 AM Peter Harris, Mayo Clinic
'Animal models of PKD'

9:20 - 9:40 AM Steve Somlo, Yale University
'Towards a molecular understanding of polycystic kidney disease'

9:40 - 10:00 AM Horacio Cantiello, Harvard Medical School, Massachusetts General Hospital 'The regulation of polycystin-2'

10:00 - 10:20 AM Gerd Walz, University Freiburg, Germany
'Polycystin-2 triggers cellular activation'

10:20 - 10:40 AM Peter Vassilev, Harvard Medical School/Brigham and Women's Hospital
'Non-selective cation channels modulated by Ca2+ sensing receptors'

10:40 - 11:00 AM Discussion and Break

Session IV - Interaction of the polycystins (Moderator, Jing Zhou)

11:00 - 11:20 AM Greg Germino, Johns Hopkins University School of Medicine
'Co-assembly of polycystin-1 and -2'

11:20 - 11:40 AM Montaha Lakkis, Harvard Medical School, Brigham and Women's Hospital 'Functional characterization of the polycystin-1 protein complex'

11:40 - 12:00 PM Patricia Wilson, Mt. Sinai School of Medicine
'Multiprotein complexes containing polycystin-1, -2, and TRP related proteins'

12:00 - 12:15 PM Discussion

12:15 - 12:45 PM Roscoe Brady, National Institute for Neurological Disorders and Stroke 'Gene therapy for neurogenetic diseases'

12:45 - 1:00 PM Closing Remarks - Susan A. Slaugenhaupt
Jordan Glaser, ML4 Foundation

1:00 - 2:00 PM Lunch at Neuroscience Center

2:00 PM Busses Depart Neuroscience Center for airports

Organized by:

Susan A. Slaugenhaupt/ML4 Foundation

Invited Speakers:

Dr. Raphael Schiffmann NINDS, NIH
Dr. Janine Smith National Eye Institute, NIH
Dr. Gideon Bach Hadassah Hospital, Israel
Dr. Susan Slaugenhaupt Harvard Medical School, Massachusetts General Hospital
Dr. Ehud Goldin NINDS, NIH
Dr. Giovanna Spinella NINDS, NIH
Dr. Giuseppe Borsani TIGEM, Italy
Dr. Mei Sun NINDS, NIH
Dr. Edwin Kolodny New York University School of Medicine
Dr. Craig Montell Johns Hopkins University School of Medicine
Dr. Baruch Minke The Hebrew University/Hadassah Medical School, Israel
Dr. Michael Zhu Ohio State University
Dr. Shmuel Muallem University of Texas Southwestern Medical Center
Dr. Viet Flockerzi Universitat des Saarlandes, Germany
Dr. Indu Ambudkar NIDCR, NIH
Dr. Jing Zhou Harvard Medical School, Brigham and Women's Hospital
Dr. Gregory Germino Johns Hopkins University School of Medicine
Dr. Peter Harris Mayo Clinic
Dr. Stefan Somlo Yale University
Dr. Horacio F. Cantiello Harvard Medical School, Massachusetts General Hospital
Dr. Gerd Walz University Freiburg, Germany
Dr. Peter Vassilev Harvard Medical School, Brigham and Women's Hospital
Dr. Patricia Wilson Mount Sinai School of Medicine
Dr. Hanna Fares University of Arizona
Dr. James F. Gusella Harvard Medical School, Massachusetts General Hospital
Dr. Roscoe Brady NINDS, NIH
Dr. Donald Gill University of Maryland
Dr. Melissa Jungnickel Florman Lab, University of Massachusetts Medical School
Dr. James Putney NIEHS
Dr. Reinhold Penner University of Hawaii

Deadline for Abstracts:

no abstracts

Registration:

www.ml4.org 'whats new'

E-mail:

slaugenh@helix.mgh.harvard.edu

Posted by:

Susan Slaugenhaupt

Host:

him61140.med.harvard.edu