Worcester Translational Research Conference
	University of Massachusetts Medical School , Hoagland-Pincus Conference Center, Shrewsbury, Massachusetts 9/24 & 9/25/99
	Friday, September 24, 1999 Cell Therapy approaches to immunomodulation Autologus cell separation and stimulation · In vivo and in vitro modulation of autologous cells · Optimal collection of immune and stem cell populations · Conditioning therapy and transplant timing Allogenic cell therapy and immunodynamics · Stem, immune and supporting populations · conditioning therapy and transplant timing Basic Science: Immune modulation during transplant, minimal myeloablative approaches, costimulator blockade: 7:00-7:30 Registration and Continental Breakfast 7:30-7:50 AM Welcoming remarks and dedication Robert VB Emmons, MD 7:50-8:30 AM Overview: Animal Models of Transplant for Autoimmunity DW van Bekkum, MD 8:30-9:10 AM Minimal myeloablative approaches to stem cell transplant and introduction to costimulator blockade Peter J. Quesenberry, MD 9:10-9:40 AM New intense approaches for the treatment of autoimmune diseases: cure or treatment free remission? Alberto M. Marmont, MD 9:40-10:00 BREAK 10:00-10:40 AM Basic studies into the pathogenesis of Systemic Lupus John H. Klippel, MD 10:40-11:20 AM Basic understanding of multiple sclerosis Henry F. McFarland, MD 11:20-12:00 PM Clinical experience in the Northwestern trial for MS Bruce Cohen, MD 12:00-1:00 PM LUNCH, posters open 1:00-1:40 PM Minimal myeloablative transplant approaches Shimon Slavin, MD 1:40-2:20 PM Clinical experience in the Northwestern trial for SLE Ann E. Traynor, MD 2:20-3:00 PM Costimulator blockade, CTLA4Ig TBA - Harvard Medical School 3:00-3:40 PM Animal models of double costimulator blockade Megan Sykes, MD 3:40-4:10 PM The use of CD40L Ab blockade: Update on preclinical and clinical data Kari Nadeau 4:10-4:50 PM 2 talks by chosen basic science posters: ASH format, 10 min talk and 5 min Q/A 4:50-5:20 PM Panel discussion: Emphasis for future study in immune modulation for stem cell transplantation Saturday, September 25, 1999 Clinical trial update and planning Review of ongoing clinical trials · Systemic Sclerosis · Systemic Lupus · Rheumatoid Arthritis · Multiple Sclerosis · Hematologic autoimmune disease Regulatory issues and standards · Insurance issues · Data collection Clinical Trial Planning Day Two: Clinical Science: Review of trials in progress and the future: 7:00-7:30 Registration and Continental Breakfast 7:30-7:50 AM Opening remarks Robert VB Emmons, MD 7:50-8:20 AM The American transplant registry for autoimmune transplants Mary Horowitz, MD 8:20-9:00 AM Role of stem cells in stem cell transplants for autoimmunity Richard K. Burt, MD 9:00-9:40 AM Non-transplant approaches to high dose therapy Robert Brodsky, MD 9:40-10:00 AM BREAK 10:00-10:30 AM Overview of European trials in autoimmune transplants Alan Tyndall 10:30-11:00 AM Review of the multi-institutional trial for scleroderma Peter McSweeny, MD 11:00-11:50 PM Insurance panel discussion: US Representative James P. McGovern - 3rd Massachusetts District Kathleen Goonan, MD Vice President, Clinical Performance Improvement UMass Memorial Health Care 11:50-12:50 LUNCH: posters open 12:50-1:20 Clinical overview of RA with reference to transplant Richard Pope, MD 1:20-2:10 PM Clinical experience in the Nebraska trial for RA Zivko Steven Pavletic, MD 2:10-2:40 PM Clinical experience in the European trial for JRA Nico Wulfraat, MD 2:40-3:00 PM BREAK 3:00-3:30 PM Clinical experience in the City of Hope trial for MS Ashwin Kashyap, MD 3:30-4:00 PM Clinical experience in the NIH trial for ITP Cynthia Dunbar, MD 4:00-4:30 PM Clinical experience in transplant for SLE in China Jian Ou-Yang, MD 4:30-5:00 PM 2 talks by chosen clinical science posters: ASH format, 10 min talk and 5 min Q/A 5:00-5:30 PM Panel discussion: North American Review of Data Collection Forms: regimens, cooperation, allogeneic transplant and the role of costimulator blockade
	Organized by:	Ted Purcell
	Invited Speakers:	Course Directors Richard K. Burt, MD* Assistant Professor of Medicine Director, Allogeneic Bone Marrow Transplantation Division of Hematology/Oncology Department of Medicine Robert V.B. Emmons, MD* Assistant Professor of Medicine, Division of Hematology/Oncology University of Massachusetts Medical Center Presenting Faculty and Moderators: Dirk W. van Bekkum, MD Introgene, The Netherlands Robert Brodsky, MD Assistant Professor, Oncology - Hematologic Malignancies, Johns Hopkins University School of Medicine Richard Burt, MD Assistant Professor of Medicine Director, Allogeneic Bone Marrow Transplantation Division of Hematology/Oncology Department of Medicine Bruce Cohen, MD Professor of Neurology, Northwestern University Medical School and Director, Multiple Sclerosis Clinic, Northwestern Medical Faculty Foundation. Cynthia Dunbar, MD Senior Clinical Investigator National Heart, Lung and Blood Institute, National Institutes of Health NHLBI, NIH dunbarc@gwgate.nhlbi.nih.gov Robert V.B. Emmons, MD* Assistant Professor of Medicine, Division of Hematology/Oncology, University of Massachusetts Medical Center Kathleen Goonan, MD Vice President, Clinical Performance Improvement UMass Memorial Health Care Mary Horwitz, MD Scientific Director, Professor of Medicine, International Bone Marrow Transplant Registry and Autologous Blood and Marrow Registry, Health policy Institute, Medical College of Wisconsin IBMTR/ABMTR 414-456-8325 Ou-Yang Jian Department of Hamatology Drum Tower Hospital of Nanjing, Jiangsu 210008 PR China 86-25-3306779 fax 86253317016 Ashwin Kashyap, MD Department of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, California 91010, USA John H. Klippel, MD Clinical Director, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health Randall R. Long, MD, PhD* Associate Professor and Vice Chair, Department of Neurology, University of Massachusetts Medical School Alberto M. Marmont, MD Division of Hematology, S. Martino's Hospital, Genoa, Italy Henry F. McFarland, MD Chief, Neurology, Immunology Branch, NINDS Peter McSweeney, MD Denver, University of Colorado, Bone Marrow Transplant Program 4200 East 9th Ave Box B190, Denver 80262 303-372-9267 303-372-9003 fax peter.mcsweeney@uchsc.edu James P. McGovern United States Representative 3rd Massachusetts District Kari Nadeau Biogen Su Chang Nanjing University, Nanjing China Zivko Steven Pavletic, MD Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198 Richard M. Pope M.D. Maybel Meyers Greene Professor of Medicine Chief, Division of Rheumatology, Northwestern University School of Medicine Peter J. Quessenberry, MD Director, Cancer Center University of Massachusetts Medical School Shimon Slavin, MD Head, Bone Marrow Transplant Unit, Hadassah-Hebrew University Medical Centers Megan Sykes, MD Departments of Surgery and Medicine, Harvard Medical School, Massachusetts General Hospital, Bone Marrow Transplantation Section, Transplantation Biology Research Center MGH-East, Building 149-5102, 13th Street Boston, MA 02129 Tel: (617) 726-4070 FAX: (617) 724-9892 Email: sykes@helix.mgh.harvard.edu Ann E. Traynor, MD Director, Stem Cell Transplant Program for Systemic Lupus Assistant Professor of Medicine Northwestern University School of Medicine Alan Tyndall, MD Dept of Rheumatology Basel University Rhematologische Universitatsklinik Felix Platter-Spital Burgfelderstrasse 101 CH-4055 Basel Switzerland Nico Wulffraat, MD Utrecht BMT Program Holland, the Netherlands 01131302504003 fax01131302505350 Robert B. Zurier, MD* Professor of Medicine, Cell Biology and Pathology, University of Massachusetts Medical Center · denotes member of the Planning Committee
	Deadline for Abstracts:	8/15/99
	Registration:
	Email for Requests and Registration:	continuing.education@umassmed.edu
	Posted by: Ted Purcell   Host: 146.189.95.138 date: July 21, 1999 16:53:56 Generated by meetings and positions 2.0 by Kai Garlipp Logo and Logo Images by Art for BioMed / Syrinx GmbH - Frankfurt / Germany. 4.1 (c) 1995-99 HUM-MOLGEN. All rights reserved. Liability and Copyright.