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International Conference on Transplantation
with Emphasis on Kidney

Medical Faculty University of Ljubljana
, Korytkova 2, Ljubljana, Slovenia
October 8-9, 1998

Invited Speakers: Honorary Guest Speaker
Steen Olsen (Denmark)
Invited Speakers
Jean-Pierre Cosyns (Belgium)
Bella Ivanyi (Hungary)
Pavel Rossmann (Czeck Republic)

Under the Auspicies of

Medical Faculty University of Ljubljana
University Medical Centre, Ljubljana


Organizing/Scientific Committee

President
Dusan Ferluga
Vice-President
Andrej F. Bren
Secretary General
Alenka Vizjak
Members
Jadranka Buturovic,Asta Hvala,Vesna Jurcic,Aljosa Kandus,Stasa Kaplan-Pavlovcic,Mira Koselj,Rado Kveder,Bostjan Luzar,Rafko Ponikvar,Tomaz Rott,Aleksandar Vodovnik
Technical Secretaries
Mida Kandus
Vlasta Krfogec

Conference Venue
Main Lecture Room and other facilities of the Medical Faculty University of Ljubljana
Korytkova 2, 1000 Ljubljana, Slovenia


WELCOME MESSAGE

Dear Colleagues and Friends,

Rejection still plays a major role in transplanted organ survival despite significant progress in immunosuppression treatment. The kidney is by no means exception in this.
Much effort has been invested by world experts over the last decade to standardize practical, simple, reproducible, and clinically relevant histopathological criteria for the diagnosis of renal allograft rejection by needle biopsy, which remains the most definitive diagnostic procedure. Stimulated by standardization efforts in heart and lung transplantation, the Banff attempts to define certain thresholds more precisely and to specify grades of rejection and borderline changes signify major progress and have proved to be useful, although the opinion has been expressed that they still have limitations and seem to be rather complex in practice. The honorary guest lecturer, Professor Steen Olsen, from Denmark, who will present two introductory overview talks at this International Conference on Transplantation, has contributed significantly to the development of modern nephropathology and has played a very prominent role in the group of international experts for establishing and standardizing of rejection criteria. The Conference will also provide opportunities for pathologists and clinicians from Slovenia and other countries to present their own scientific results, to exchange practical experiences and to discuss diagnostically difficult cases. It will be open to practicing specialists in different branches of medicine and to residents who would like to upgrade their knowledge about the very complex pathology of organ transplantation. We expect that the Conference will demonstrate the importance of close collaboration between clinicians and pathologists in everyday clinical praxis as well as in scientific projects.
The organizers are honored and proud to be the hosts of the Conference and will make every effort to ensure the best conditions for the realization of the scientific programme and social contacts between participants, in the modern premises of the Medical Faculty and University Medical Centre in Ljubljana. Furthermore, you are all kindly invited to enjoy the architectural heritage of Ljubljana and the picturesque countryside of tiny Slovenia. We sincerely wish that your attendance at the International Conference on Transplantation with Emphasis on Kidney will be a fruitful, enjoyable and memorable experience.

Dusan Ferluga
Andrej F. Bren

Program:
SCIENTIFIC PROGRAMME

THURSDAY, OCTOBER 8
Main Lecture Room

Opening Ceremony

09.00
Welcome Addresses
Concert Programme
F. Molino: Nocturno (Rondo pastorale)
J. Ibert: Entr?acte
Andreja Cerne - flute, Alenka Okorn - guitar

09.30
Refreshments

Transplantation Programme in Slovenia

Chair: A. Kandus (Ljubljana), J. Voncina (Ljubljana)

09.45
Transplantation programme in Slovenia
J. Voncina, D. Avsec Letonja (Ljubljana)
10.00
Multiple organ procurement
F. Omejc (Ljubljana)
10.15
Clinicopathological issues of liver transplantation. Present situation of liver transplantation program in Slovenia
V. Sojar (Ljubljana)
10.20
Pathohistological support to liver transplantation - when, why and how
V. Ferlan-Marolt (Ljubljana)
10.25
Heart transplant pathology - our biopsy experience
Z. Dolenc-Strazar, D. Zorman (Ljubljana)
10.30
Transplantation of bone tissue
S. Herman (Ljubljana)
10.35
Skin transplantation
F. Planinsek, Z.M. Arnez (Ljubljana)
10.40
Ten years of allogenic haematopoetic stem cell transplantation for leukemia in University Medical Centre Ljubljana - Slovenia
J. Pretnar (Ljubljana)
10.45
State of kidney transplantation in Slovenia
A. Kandus (Ljubljana)
11.05
Discussion

11.15
Coffee break

Pathology of Renal Allograft

Chair: P. Rossmann (Prague), D. Ferluga (Ljubljana)

11.30
Pathology of renal allograft (Honorary Guest Lecture)
S. Olsen (Copenhagen)
12.20
Inter - observer reproducibility of the Banff classification of renal allograft rejection
J.P. Cosyns (Bruxelles)
12.30
Peritubular capillaries in acute and chronic renal allograft rejection: A quantitative ultrastructural study (Invited Lecture)
B. Iványi (Szeged)
12.45
Histopathology of renal allograft vasculature segments in kidney allograft rejection
D. Ferluga, S. Kovac, A. Vranic, V. Jurcic (Ljubljana)
13.00
Lesions in donor kidneys: nature, incidence and influence on graft function (Invited Lecture)
J.P. Cosyns (Bruxelles)
13.15
Discussion

13.35-15.00
Lunch break

Chair: J. Stejskal (Prague), A. Vizjak (Ljubljana)

15.00
Immunohistochemistry of renal allograft biopsy and its significance (Invited Lecture)
P. Rossmann, J. Jirka, K. Matousovic, M. Chadimová (Prague)
15.15
Immune reactant deposits in renal transplant biopsies
A. Vizjak, V. Jurcic, D. Ferluga (Ljubljana)
15.30
Adhesion molecules in kidney allograft rejection
V. Jurcic (Ljubljana)
15.40
Accelerated athero-arteriolosclerosis in renal allograft
D. Ferluga, V. Jurcic, T. Rott, A. Hvala, A. Vizjak (Ljubljana)
15.50
Rejection phlebitis in kidney allograft - yes or no
V. Jurcic, A. Vranic, S. Kovac, D. Ferluga (Ljubljana)
15.55
Pseudo-vasculitis consequent to allograft vessel thrombosis
A. Vodovnik, V. Jurcic, D. Ferluga (Ljubljana)

16.00
Glomerular and arteriolar lesions during chronic kidney rejection
A. Dinulescu, E. Mandache (Bucharest)
16.10
Discussion

16.25
Coffee break

Clinical Diagnosis of Rejection and Allied Conditions. Immunosuppresion Therapy

Chair: J.P. Cosyns (Bruxelles), A.F. Bren (Ljubljana)

16.40
Clinical aspects of kidney graft rejection and treatment
J. Buturovic, A. Kandus (Ljubljana)
16.55
Ultrasound and Doppler in kidney transplantation
J. Buturovic (Ljubljana)
17.05
Acute graft rejection: the importance of idividual resistive index value in duplex color Doppler follow up
V. Mozetic, P. Orlic, Z. Fuckar, I. Maleta, S. Racki, R. Ogvic (Rijeka)
17.15
Urological complications of renal transplantation
C. Oblak, B. Trsinar (Ljubljana)
17.25
Haemolytic-uremic syndrome after cyclosporine treatment in kidney graft recipients
A.F. Bren, A. Kandus, J. Buturovic, M. Koselj, S. Kaplan, R. Ponikvar, D. Kovac, J. Lindic,
A. Vizjak, D. Ferluga (Ljubljana)
17.35
Recurrence of focal glomerulosclerosis after kidney transplantation
S. Kaplan-Pavlovcic, D. Ferluga, A. Vizjak, A. Hvala (Ljubljana)
17.45
IgA recurrent disease in renal graft recipients
M. Koselj, A. Kandus, T. Rott, A. Vizjak (Ljubljana)
17.55
Aspergillosis in renal transplant recipients
T. Rott, M. Koselj, A. Kandus (Ljubljana)
18.05
Discussion


THURSDAY, OCTOBER 8
Entrance Hall

Poster Exhibition

09.30 - 18.00

Poster 1
Specificity of interstitial capillary changes in transplanted kidneys
A. Hvala, D. Ferluga, T. Kobenter, T. Rott, M. Koselj, S. Kaplan-Pavlovcic, I. Jaksa, S. Trnacevic (Ljubljana, Tuzla)
Poster 2
Early vascular anastomosis complications in renal transplantation
A. Kmetec (Ljubljana)
Poster 3
Laparotomy versus laparoscopic management of posttransplant lymphocoele - our experience
A. Kmetec (Ljubljana)
Poster 4
Mycophenolate mophetil in pediatric renal transplantation
G. Novljan, J, Buturovic A. Kandus, R. Kenda (Ljubljana)
Poster 5
Serious morphological changes in the donor kidney, onset of function and graft survival
E. Pokorná, S. Vitko, M. Chadimová, O. Schück (Prague)

FRIDAY, OCTOBER 9
Main Lecture Room

Native and Transplant Acute Renal Failure

Chair: B. Iványi (Szeged), F. Ponikvar (Ljubljana)

09.00
Native and transplant acute renal failure (Honorary Guest Lecture)
S. Olsen (Copenhagen)
09.50
Clinical aspects of native and transplant acute renal failure
F. Ponikvar (Ljubljana)
10.05
Discussion

10.20
Coffee break

Pitfalls and Clinico-Pathological Correlations in Kidney Transplantation

Chair: S. Kaplan-Pavlovcic (Ljubljana), T. Rott (Ljubljana)

10.35
Interferon-alpha associated rapidly progressive renal graft failure in patient with chronic myelogenous leukemia
A.F. Bren, A. Kandus, D. Ferluga (Ljubljana)
10.50
Significance of nephron mass for the survival of renal graft and the prognosis of renal disease
A. Zidar, D. Ferluga (Ljubljana)
11.00
Nondiabetic nodular glomerulosclerosis in renal allograft patient with Alport's syndrome
B. Luzar, A. Licina, A.F. Bren, A. Hvala, A. Vizjak, D. Ferluga (Ljubljana)
11.10
Discussion

11.20
Round Table Discussion
Moderators: S. Olsen (Copenhagen), D. Ferluga (Ljubljana), A. Kandus (Ljubljana)
Invited Participants: A.F. Bren, J. Buturovic, J.P. Cosyns, D. Felle, V. Ferlan-Marolt, B. Iványi, S. Kaplan-Pavlovcic, C. Oblak, P. Orlic, P. Rossmann, T. Rott, V. Sojar, A. Vizjak, J. Voncina

Main issues: Significance of allograft biopsy
Classification of renal allograft rejection histopathology (Banff schema)
Cyclosporine nephrotoxicity
Zero allograft biopsy

12.55
Closing remarks
D. Ferluga (Ljubljana)

Registration :
There will be no registration fee for participation at the scientific events of the Conference.
A Registration and Information Desk will be available for the participants on October 8, 8.00 - 18.00, and on October 9, 8.00 - 13.00 in the Entrance Hall of the Medical Faculty.

GENERAL INFORMATION

Official Language
English only. There will be no simultaneous translation.

Oral and Poster Presentations
All speakers are kindly requested to keep their presentations within the given time limits. Slides can be reviewed in the slide preview room at least 30 minutes before the start of the session. The speakers are asked to use the standard 24x36 mm slides mounted in the 50x50 mm frames marked with the name of the speaker and successive number. After the presentation, speaker can pick up his slides in the slide preview room. Overhead projector will be available in the Main Lecture Room.
Posters will be exhibited in a specially marked area of the Entrance Hall in front of the Main Lecture Room. Vertical display boards for posters measure 120 cm height x 100 cm width. Pins and tape will be available at the Registration Desk. The authors are requested to fix the posters on Thursday, October 8, between 8.30 and 9.00 and collect them the same day between 18.00 and 18.30.

Certificate of Attendance
A Certificate of Attendance will be issued at the Registration Desk.

Trade Exhibition
The commercial exhibition will be located in the Entrance Hall of the Medical Faculty.

Ljubljana
Ljubljana, the capital of Slovenia, is in the centre of the country, only an hour's drive from the Alps or the Adriatic Sea. Modern Ljubljana is built on the remnants of Roman Emona. Below the castle, there is a picturesque medieval town with an ancient cultural tradition which we hope guests will find time to explore.

Climate
Ljubljana has a central European climate. In October, the weather could be pleasant with an average day temperature of 15°C. However, it can be changeable and rainy and participants are advised to bring a raincoat or umbrella and warmer dress.

Currency Exchange
Foreign currency may be exchanged at banks and exchange offices, at travel agencies, hotels, at the airport and railway station. All major credit cards are widely accepted in hotels, restaurants, and stores. The Slovenian currency is the tolar (SIT). The exchange rate for 1 USD is approximately 170 SIT.

Meals
There is a restaurant in the University Medical Centre and several other restaurants within walking distance of the Conference Venue.

Commercial Exhibitors and Sponsors of the Conference

Novartis Pharma Services Inc. Podruznica v Sloveniji
Dunajska cesta 22, 1000 Ljubljana

Lek, tovarna farmacevtskih in kemicnih izdelkov, d.d.
Verovskova ulica 57, 1000 Ljubljana

Hoffmann La Roche Ltd. Podruznica Ljubljana
Dalmatinova 10, p.p. 4351, 1001 Ljubljana






Deadline for Abstracts: Sept 15, 1998

Email for Requests and Registration: luzar@ibmi.mf.uni-lj.si

Posted by: Institute of Pathology Host: ALEKSANDERV-PC.mf.uni-lj.si date: September 30, 1998 9:56:07
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