Invited Speakers: KEYNOTE: Stuart Schreiber, HHMI, Harvard
Carlos Barbas, Scripps
Ron Barrett, Affymax
Paul Bartel, Myriad Genetics
Helen Blau, Stanford
Roger Brent, Molecular Sciences Institute
James Broach, Princeton
Gerald Crabtree, HHMI, Stanford
Reto Crameri, Swiss Institute, Davos
Stan Fields, HHMI, University of Washington
Michael Gilman, ARIAD Pharmaceutical
Hennie Hoogenboom, Univ. Hosp., Maastricht
Jarko Kochan, Hoffmann-La Roche
Pierre Legrain, Institut Pasteur
Lawrence Loeb, University of Washington
Gary Nolan, Stanford
Carl Pabo, HHMI, MIT
Don Payan, Rigel
Andreas Plückthun, Universitat Zurich
Mike Roth, Tularik
Gerald Rubin, HHMI, U.C. Berkeley
Erkki Ruoslahti, Burnham Institute
Robert Sauer, MIT
Peter Schultz, HHMI, U.C. Berkeley
Paul Sternberg, HHMI, Cal Tech
Jeremy Thorner, U.C. Berkeley
Roger Tsien, HHMI, U.C. San Diego
Marc Vidal, MGH Cancer Center
James Wells, Genentech
Marvin Wickens, University of Wisconsin
Kleanthis Xanthopoulos, Aurora Biosciences
Program:
Tentative Schedule:
Sunday October 18
3:00 - 7:00 PM Registration
Monday October 19
7:00 - 8:30 AM Registration
8:30 AM Welcome
8:40- 9:25 AM Keynote Address: Stuart Schreiber
9:25- 9:50 AM Stan Fields: The Two-Hybrid System: Newer roles and bigger jobs
9:50- 10:20 AM Break
Session 1 - Protein Interactions Methodologies
10:20- 10:45 AM Jarko Kochan: The Yeast Tribrid System: A Means of target and lead identification
10:45- 11:10 AM Helen Blau: Protein Interactions Monitored in Live Cells via ß-galactosidase Complimentation
11:10- 11:35 AM Jeremy Thorner: A Differential Interaction Trap Assay for Dissection of Protein-protein Interactions
Stephen Michnick: Putting Protein Folding to Work: Oligomerization domain- directed reassembly of active enzymes from fragments as a protein design strategy and for functional relationships among proteins in vivo
11:35- 12 Noon Andreas Pluckthun:
12N-1:30 PM Luncheon for Speakers
Session 2 - Drug Screening
1:30- 1:55 PM Michael Gilman: Imparting Small-molecule Control to Gene and Cell Therapy
1:55- 2:20 PM Kleanthis Xanthopoulos: Integrating Genome-wide Functional Analysis with High- throughput Systems
2:25- 2:45 PM Garry Nolan: Retroviruses for Functional Genomic Analysis and Motif Generation
2:45- 3:10 PM Don Payan: Retrovirally Delivered Combinatorial Libraries for Pathway Mapping
3:10- 3:35 PM James Wells: Pleiotropic binding at hormone-receptor interfaces
3:35- 4:05 PM Break
Session 3- Chemistry
4:05- 4:30 PM Gerald Crabtree:
4:30- 4:55 PM Roger Tsien: Imaging Protein Interactions in Live Cells
4:55- 5:20 PM Peter Schultz: Functional Molecules: A Lesson from Nature
Tuesday, October 20
Session 4- Peptides/Antibodies/Phage Display
8:45- 9:10 AM Ron Barrett: Identification of Cell Surface Receptor Ligands from Encoded Combinatorial Libraries
9:10- 9:35 AM Reto Crameri: Selective enrichment and high throughput screening of cDNA clones from complex allergenic systems
9:35- 10:00 AM Hennie Hoogenboom:
10:00- 10:25 AM Erkki Ruoslahti:
10:25- 10:55 AM Break
Session 5- Nucleic Acid/Protein Interactions
10:55- 11:20 AM Lawrence Loeb:
11:20- 11:45 AM Robert Sauer:
11:45AM- 12:10 PM Marvin Wickens: Analysis of RNA-protein interactions and 3'UTR regulation in
C. elegans germline development
12:10- 12:35 PM Carlos Barbas:
12:35- 1:30 PM Luncheon for Speakers
Session 6- Genomics
1:30- 1:55 PM Pierre Legrain: Exhaustive analysis of viral, microbial, and yeast genomes through genomic two-hybrid screens
1:55- 2:20 PM Marc Vidal: A C. elegans protein interaction mappi ng project
2:20- 2:45 PM Paul Bartel:
2:45- 3:10 PM Michael Weiner:
3:10- 3:35 PM Roger Brent::
3:35- 4:05 PM Break
Session 7- Model Systems
4:05- 4:30 PM James Broach: Selection of Novel Peptide Ligands for Orphan G Protein-Coupled Receptors
4:30- 4:55 PM Paul Sternberg: Whole organism gene interaction analysis: gene discovery and pathway definition in C. elegans
4:55- 5:20 PM Gerald Rubin:
Registration :
For More Information Contact:
The Palo Alto Institute of Molecular Medicine
2462 Wyandotte Street
Mountain View, CA 94043, USA
Tel: 650.694.1420 Fax: 650.694.7717
E-Mail: paimm@netgate.net
Web site: www.pano.com/paimm
Deadline for Abstracts: 10/1/98
Email for Requests and Registration: paimm@netgate.net