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CYPRUS '98: New Technologies and Frontiers in Drug Research

IOCD and ARRT International , Limassol, Cyprus
05/04/98 - 05/08/98

Invited Speakers: As of 11/97

Harold Meyers, Sphinx/Lilly, USA

Alexey Eliseev, SUNY Buffalo, USA

Jin Li,Proteus Molecular Design, UK

Petr Kocis, Zeneca Pharmaceuticals, USA

Edward Wintner,Neogenesis, USA

Bruce Cornell, AMBRI/CRC Chatswood, Australia

Alfred Kolb, Packard Instrument, USA

J. Rushbrooke, Cambridge Imaging, UK

C.G.Morgan, Salford U, UK

Hermann Gaub, Techn U Munich, Germany

Richard J. Colton, Naval Research Laboratory, Washington, DC

James Gimzewski, IBM Research, Switzerland

John Devlin, ARRT International, USA

Thomas Wellems, Laboratory of Parasitic Diseases, NIAID/NIH, USA

W. Sirawaraporn, Mahidol University, Thailand

R. Ridley, Hoffmann LaRoche

Fred Opperdoes, Research Unit for Tropical Diseases, Catholic U Louvain, Belgium

Program:
This remarkable conference addresses emerging technologies
in drug discovery with special attention to their impact on
the chemical and biochemical sciences. Sessions have been
designed to present both background and futures and to
provide optimal opportunity for discussion. In addition,
special symposia on Applications of Structure-Based Design
and Genomics in the Discovery of New Antimalarials and
Challenges in Drug Design in Tropical Diseases have been
included to bring forth the remarkable research advances in
mechanism-based drug design in this area and the critical
need for increased industrial participation in the
resolution of a major worldwide health problem. The
lecturers who have been invited to participate in Cyprus '98
have been selected on the basis of their prominence in the
fields addressed.

The program is designed for research managers and other
pharmaceutical executives seeking a frontline view of emerging
technologies and the associated opportunities in drug discovery.

PROGRAM

* Monday, May 4th
Morning: The Changing Role of Chemistry in Drug Discovery
(Chair: Harold Meyers, Sphinx/Lilly, USA) Beyond Rational
Drug Design and Combinatorial Chemistry - What Lies Ahead?
(Harold Meyers, Sphinx/Lilly, USA) Dynamic Combinatorial
Chemistry: Evolutionary Formation and Screening of Molecular
Libraries (Alexey Eliseev, SUNY Buffalo, USA) Integration of
Structure-Based Design and Combinatorial Chemistry (Jin Li,
Proteus Molecular Design, UK)
Afternoon: Systematics in the Design and Production of
Combinatorial Libraries (Petr Kocis, Zeneca Pharmaceuticals,
DE, USA) New Methods of Small Molecule Detection in
Mixture-Based Combinatorial Chemistry (Edward Wintner,
Neogenesis, USA)
Selected Short Oral Papers from Poster Presentations
Evening: Conference Reception (Hawaii Beach Hotel)

* Tuesday, May 5th
Morning: Chemical Aspects of Membrane Components and Drug
Transport (Chair: TBA) Topics: Macromolecular Interactions
in Receptor-ligand Coupling; Signal Transduction; Role and
Stereochemical Characteristics of Membrane Carbohydrates in
Transport Mechanisms Afternoon: Artificial Membrane
Applications in Lead Detection and Drug Development (Chair:
Bruce Cornell, AMBRI/CRC Chatswood, Australia) Topics:
Trans-membrane Measurements; Ion Channel Structure and
Mimicry; Molecular Self-assembly Mechanisms
Selected Short Oral Papers from Poster Presentations
Evening: Civic Reception at Limassol City Hall

* Wednesday, May 6th: Full Day Break Relax and enjoy Cypriot
sun and hospitality, or join your colleagues in the full day
Excursion into ancient Cyprus (optional, separate charge).

* Thursday, May 7th
Morning: Biomolecular Detection Mechanisms at Picomolar
Concentrations (Chair: Alfred Kolb, Packard Instrument, USA)
Nanoscale Detection of Biochemical Interactions (Alfred
Kolb) High Density Imaging (J. Rushbrooke, Cambridge
Imaging, UK) New Luminescence Technologies for Biochemical
Assays (C.G.Morgan, Salford U, UK)
Afternoon: Measurement of Single Molecule Binding (Chair:
Hermann Gaub, Techn U Munich, Germany) The Chemical Physics
of Single Molecule Action (Hermann Gaub) Biosensors Based on
Molecular Recognition Force Measurements Between Individual
Molecules (Richard J. Colton, Naval Research Laboratory,
Washington, DC) Silicon Micromechanics and Fluidics in the
Array Analysis of Biochemical Reactions (James Gimzewski,
IBM Research, Switzerland)
Selected Short Oral Papers from Poster Presentations
Evening: Discussion Panel on Limits of Micronization in
Chemical Synthesis and Biology (Coordinator: John Devlin,
ARRT International, USA)

* Friday, May 8th
Morning: Applications of Structure-Based Design and Genomics
in the Discovery of New Antimalarials (Chair: Thomas
Wellems, Laboratory of Parasitic Diseases, NIAID/NIH, USA)
Identification of a Key Protein in the Chloroquine
Resistance Mechanism, Implications for Drug Development
Strategies (T.E. Wellems, NIH) Plasmodium falciparum
Dihydrofolate Reductase: From Molecular Cloning to
Structural-based Design of Novel Antifolates (W.
Sirawaraporn, Mahidol University, Thailand) Aspects of
Antimalarial Drug Design (title tentative) (R. Ridley,
Hoffmann LaRoche)
Afternoon: Challenges in Drug Design in Tropical Diseases
(Chair: Fred Opperdoes, Research Unit for Tropical Diseases,
Catholic U Louvain, Belgium) Selected
Short Oral Papers from Poster Presentations
Evening: Conference Farewell Banquet (Hawaii Beach Hotel)

Registration :

* Attendance Limited, Register Today!
* Registration Fees:
before February 1, 1998: US$695, academic $395
after February 1, 1998: US$795, academic $445
* Hotels range from $54 to $108 per person per day single occupancy

CONTACT

Contact ARRT International for full information:
PO Box 1838
New Milford, CT 06776
Tel: 860-355-5195
Fax: 860-355-5975
email: arrtintl@prodigy.net

Deadline for Abstracts: Posters: March 15, 1998

Email for Requests and Registration: arrtintl@prodigy.net


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