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Gene Therapy of Cancer, AIDS and Genetic Disorders

International Centre for Genetic Engineering and Biotechnology , Trieste, Italy
10-13 April 1996

Invited Speakers: K.I. Berns (New York)
C. Bordignon (Milan)
A. Cattaneo (Trieste)
M. Collins (London)
P. Denefle (Vitry-sur-Seine)
M. Dexter (Manchester)
M.C. Dinauer (Indianapolis)
D. Engelke (Ann Arbor)
M. Giacca (Trieste)
M. Grez (Frankfurt)
W.H. GŁnzburg (Neuherberg)
G. Hadlaczky (Szeged)
J.P. Hossle (Zurich)
B.E. Huber (Research Triangle Park)
C. Indolfi (Naples)
W. James (Oxford)
D. Jolly (San Diego)
L. Luzzatto (New York)
H.L. Malech (Bethesda)
W. A. Marasco (Boston)
M. Mehtali (Strasbourg)
R. Mertelsmann (Freiburg)
G. Palu' (Padova)
M. Perricaudet (Villejuif)
J. Rossi (Loma Linda)
M. Sadelain (New York)
R.J. Samulski (Chapel Hill
N. Sarver (Bethesda)
K. Sikora (London)
B. Sullenger (Durham)
A. Szalay (Alberta)
A.J. Thrasher (London)
T. Velu (Bruxelles)
R. Walker (Bethesda)
F. Wong-Staal (San Diego)

Program:
PRELIMINARY PROGRAMME

WEDNESDAY, APRIL 10, 1996

10.00 Secretariat Opening:
Registration of Participants
14.30 Symposium Opening:
Welcome Addresses
15.00 Afternoon Session:
Chronic Granulomatous Disease
A.J. Thrasher (London)
AAV and retrovirus-mediated gene transfer for chronic granulomatous disease
H.L. Malech (Bethesda)
Results from a phase I clinical trial of gene therapy for p47-phox-deficient chronic granulomatous disease
M.C. Dinauer (Indianapolis)
Gene therapy for X-linked CGD in cellular and murine models
J.P. Hossle (Zurich)/M. Grez (Frankfurt)
CGD: adenovirus- and murine stem cell virus-mediated somatic gene therapy
M. Giacca (Trieste)
Functional correction of oxidase activity in haematopoietic progenitors of X-linked CGD patients
19.30 Welcome Reception


THURSDAY, APRIL 11, 1996

9.00 Morning Session:
Methodologies for Gene Transfer
W.H. GŁnzburg (Neuherberg)
Tissue targeted retroviral vectors for gene therapy of cancer
M. Collins (London)
Retroviral envelope modifications
G. Hadlaczky (Szeged)
Mammalian artificial chromosomes:potential vectors for gene therapy
A. Szalay (Alberta)
Introduction of novel genes into mammalian artificial chromosomes
K.I. Berns (New York)
Site-specific integration into the human genome by AAV
R.J. Samulski (Chapel Hill
AAV vectors in vivo
13.00 Lunch
14.30 Poster Session
15.30 Afternoon Session:
Gene Therapy of Inherited Disorders
M. Perricaudet (Villejuif)
New adenoviral vectors for gene therapy
M. Dexter (Manchester)
Title to be advised
M. Mehtali (Strasbourg)
Adenovirus-mediated gene therapy of cystic fibrosis
M. Sadelain (New York)
Retroviral-mediated transfer of a regulated human beta-globin gene
C. Bordignon (Milan)
Gene therapy for congenital and acquired immunodeficiencies


FRIDAY, APRIL 12, 1996

9.00 Morning Session:
Therapeutic Genes
J. Rossi (Loma Linda)
Strategies for enhancing the intracellular functioning of therapeutic ribozymes
A. Cattaneo (Trieste)
Title to be advised
W. A. Marasco (Boston)
Using intracellular antibodies (intrabodies) for research and gene therapy
D. Engelke (Ann Arbor)
Small therapeutic RNAs
B. Sullenger (Durham)
Ribozymes for RNA repair
13.00 Lunch
14.30 Poster Session
15.30 Afternoon Session:
Gene Therapy of AIDS
R. Walker (Bethesda)
Adoptive transfer of genetically modified syngeneic lymphocytes in HIV-discordant identical twins
F. Wong-Staal (San Diego)
Ribozyme gene therapy for HIV infection: from bench to clinic
W. James (Oxford)
The use of simulation and in vitro assays to predict ribozyme potency: pros and cons
G. Palu' (Padova)
Combined strategies for gene therapy of AIDS
D. Jolly (San Diego)
Genetic immunotherapy


SATURDAY, APRIL 13, 1996

9.00 Morning Session:
Gene Therapy of Cancer
T. Velu (Bruxelles)
Strategies for the gene therapy of brain tumors
R. Mertelsmann (Freiburg)
Somatic cell and gene therapy for patients with cancer
K. Sikora (London)
Genetic activation of anticancer chemotherapy
B.E. Huber (Research Triangle Park)
Enzyme/prodrug gene therapy for the treatment of solid tumors

Gene Therapy of Cardiovascular Disorders
P. Denefle (Vitry-sur-Seine)
Toward gene therapy of cardiovascular disorders
C. Indolfi (Naples)
Gene therapy for restenosis after PTCA
13.00 Lunch
14.30 Oral Communication Session
15.30 Afternoon Session:
Concluding remarks
N. Sarver (Bethesda)
Overview of clinical trials
L. Luzzatto (New York)
Clinical impact of gene therapy

Registration :

Registration and Hotel Accommodation Forms, as well as Abstracts Forms, can be obtained contacting:

Ms. Elisabetta Lippolis
ICGEB
Padriciano, 99
34012 Trieste, Italy

Phone: +39-40-3757.332
Fax: +39-40-226555
E-mail: courses@icgeb.trieste.it

Registration to the Symposium must be made by completing and returning the Registration and Hotel Reservation Form by mail or fax as soon as possible, and not later than March 15, 1996. Registrations will be accepted only on regular payment of the registration fee. Registration fees are as follows:

Before February 1, 1996: Regular: Lit. 600.000
Student: Lit. 400.000
After February 1, 1996: Regular: Lit. 800.000
Student: Lit. 600.000

The registration fee includes attendance at the Symposium, conference kit and abstract book, lunches, coffee breaks and cocktail reception.
Payment of the registration fee must be made either by credit card or by direct bank transfer, as indicated in the Registration and Hotel Reservation Form. Italian participants can also pay by cheque.
Attendance certificates will be issued upon request.

Participants are invited to contribute to the programme by submitting Abstracts describing their own research in the field of Gene Therapy. Poster Sessions will be held during the meeting, and oral presentations will be selected for an oral Communications Session. Abstracts must be written in English using the enclosed Abstract Form and following the instructions reported therein. Abstracts will only be considered if accompanied by Registration to the Symposium.

Deadline for Abstracts: Abstracts must be submitted to the Organizing Secretariat not later than February 1, 1996.

Email for Requests and Registration: courses@icgeb.trieste.it


Posted by: E. Lippolis Host: admin7.icgeb.trieste.it date: January 22, 96 10:07:46
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