Invited Speakers:
Program:
Revised 11/28/95
NUCLEAR STRUCTURE-GENE EXPRESSION
INTERRELATIONSHIPS
Organizers: Gary Stein, Gordon Hager and Ronald Berezney
April 30-May 6, 1996; Bolton Valley, Vermont
Tuesday 4/30
Registration
Orientation
OVERVIEW
Speaker to be Announced
Wednesday 5/1
Breakfast
NUCLEAR STRUCTURE AND TRANSCRIPTIONAL CONTROL OF PROLIFERATION
AND DIFFERENTIATION
Gordon Hager*, National Institutes Health
Gary Stein*, Univ Massachusetts
Wolfgang Deppert, Heinrich-Pette-Inst fur Experimental Virologie and Immunogie, "Regulatory
Interaction of p53 with Nuclear Targets"
Coffee Break
Donald Cleveland, Univ California-San Diego, "NuMA: A Nuclear Protein Required for Spindle
Assembly during Mitosis"
Craig Peterson, Univ Massachusetts Med Ctr, "The SWI/SNF Complex: A Chromatin Remodeling
Machine"
Jane Lian, Univ Massachusetts, "Features of Chromatin Remodelling Influencing Tissue-Specific
Expression of the Osteocalcin Gene"
Poster Set Up
Posters
Social Hour
NUCLEOSOME-TRANSCRIPTION FACTOR INTERACTIONS: STRUCTURAL AND
FUNCTIONAL ACTIVITIES IN VIVO AND IN VITRO
Michael Grunstein*, Univ California-Los Angeles, "Histone Regulation of Transcription"
Jerry Workman, Pennsylvania State Univ, "Transcription Factor-Induced Remodeling of
Chromatin Structure"
Coffee Break
Robert Kingston, Massachusetts General Hosp, "Activator Function on Nucleosomal Templates"
Speaker to be Announced
Thursday 5/2
Breakfast
THE VISUALIZATION, REGULATION AND FUNCTIONAL ACTIVITIES OF
NUCLEAR DOMAINS
Jeanne Lawrence*†Univ Massachusetts Med Sch
Jeffrey Nickerson, Massachusetts Inst Technology, "Nuclear Architecture"
Roel Van Driel, Univ Amsterdam, "Transcription Machinery: Nuclear Distribution"
Coffee Break
David Spector, Cold Spring Harbor Labs, "Nuclear Domains Involved in Trascription and
Pre-mRNA Splicing"
Andrew Belmont, Univ Illinois-Urbana, "Large Scale Chromatin Structure"
Poster Set Up
Posters
Social Hour
CONTRIBUTIONS OF NUCLEAR IMPORT, EXPORT AND TARGETING TO CELL
CYCLE CONTROL
Gunther Blobel*†Rockefeller Univ
Arthur Pardee*, Dana Farber Cancer Inst, "Cell Cycle Dependent Protein Transport into the
Nucleus"
Thoru Pederson†The Worcester Foundation
Ronald Laskey†Wellcome-CRC Inst
Laura Davis, Duke Univ Med Ctr, "FG Nucleoporins Promote Translocation across the Nuclear
Pore Complex"
Coffee Break
Ravi Dhar, National Institutes Health, "mRNA Trafficking and Cell Cycle Control in
Schizosacccharomyces pombe"
Pam Silver, Dana Farber Cancer Inst, "Co-regulation of Transport in and Out of the Nucleus"
Douglass Forbes†Univ California-San Diego
Friday 5/3
Breakfast
GLOBAL ACTIVATION AND REPRESSION OF TRANSCRIPTION: CELL AND
ANIMAL MODELS
Ulrich Laemmli*†Univ Geneva
Constanze Bonifer, Univ Freiburg, "Transcriptional Activation of Whole Genomic Loci-The
Chicken Eysozyme Locus"
Coffee Break
Jurgen Bode, Gesellschaft Fur Biotechnologische Forschung, "Dentification and Structure of
Transcriptionally Active Genomic Sites"
Speaker to be Announced
Poster Set Up
WORKSHOP: CONTRIBUTIONS FROM YOUNG INVESTIGATORS
Speakers to be selected from submitted abstracts
Posters
Social Hour
NUCLEAR STRUCTURE AND GENOME REPLICATION
Ronald Berezney*, SUNY-Buffalo
Joyce Hamlin, Univ Virginia Sch Med, "Effects of Chromosomal Context on a Chromosomal Origin
of Replication"
Melvin DePamphilis, National Institutes of Health, "Origins of DNA Replication in Mammalian
Chromosomes"
Coffee Break
David Knipe†Harvard Med Sch
David Kaufman, Univ North Carolina-Chapel Hill, "Investigations of DNA Replicated Early in the
S Phase"
Saturday 5/4
Breakfast
CONTROL OF CHROMATIN STRUCTURE AND NUCLEOSOME ORGANIZATION
Ken Van Holde*, Oregon State Univ, "Linker Histones and Chromatin Fiber Structure"
Gary Felsenfeld, National Institutes of Health, "Chromatin Structure and the Regulation of
Transcription"
James Davie, Univ Manitoba, "Histone Modifications and Nuclear Domains Involved in
Transcription"
Coffee Break
Alan Wolffe, National Institutes Health, "Nucleosome Structure and Function"
Barbara Sollner-Webb†Johns Hopkins University Poster Set Up
WORKSHOP: STATE-OF-THE-ART EXPERIMENTAL APPROACHES
Speakers to be announced
Posters
Social Hour
NUCLEAR MATRIX AND CHROMATIN TRANSITIONS IN REGULATION OF GENE
EXPRESSION
Robert Goldman*, Northwestern Univ
William Brinkley*, Baylor Coll Med, "Dynamics of Nuclear Matrix Proteins in the Cell Cycle"
Kenneth Zaret, Brown Univ, "Potentiation and Activation of Developmentally Controlled Genes in
Chromatin"
Erin O'Shea, Univ California-San Francisco, "Phosphate Metabolism and Cell Cycle Control"
Coffee Break
William Gerrard†Univ Texas SW Med Ctr
Andre J. Van Wijnen†Univ Massachusetts
Sunday 5/5
Breakfast
GENOME IMPRINTING
Rudolph Grosschedl*, Univ California-San Francisco, "Role of MAR Sequences in Chromatin
Accessibility and DNA Demethylation"
Vicki Chandler, Univ Oregon, "Paramutation: An Allelic Interaction that leads to Heritable
Changes in Transcription"
Coffee Break
Huntington Willard, Case Western Reserve Univ, "Epigenetic Regulation of X-Linked Gene
Expression"
NUCLEAR STRUCTURE IN DIAGNOSIS AND THERAPEUTICS
Donald Coffey*†Johns Hopkins Hosp
Speaker to be Announced
Coffee Break
Robert Getzenberg, Univ Pittsburgh, "Recent Studies in Cancer Associated Nuclear Matrix
Protein: Rat Prostate and Human Bladder"
Steven Ward, Robert W ood Johnson Med Sch
SUMMARY AND PROSPECTS
Sheldon Penman†Massachusetts Inst Technology
Banquet
Possible Entertainment
Monday 5/6
Breakfast
Departure
* = Session Chairperson; †= Invited, not yet responded.
Registration :
Cambridge Symposia
1037 Chestnut Street
Newton Upper Falls, MA 02164
Phone: (617)630-1399
Fax: (617)630-1395
Deadline for Abstracts: January 10, 1996
Email for Requests and Registration: symposia@cambridge.org