Invited Speakers: Dr William James (Course Director)- Sir William Dunn School of Pathology, University of Oxford
Prof Jeff Errington - Sir William Dunn School of Pathology, University of Oxford
Dr Sarah Rowland-Jones - Christ Church College Oxford and Department of Clinical Medicine/Molecular Medicine Oxford
Dr E Holmes - Dept. Of Public Health and Primary Health Care, Institute of Health Sciences Oxford and Department of Zoology Oxford
Program:
The Aim of the Course
This new course aims to give a sound introduction for non-specialists to the fast-changing area of infectious disease. It explores the biological challenges, from re-emergent viruses to antibiotic resistance, and the new approaches to tackling them, from novel vaccines to combinatorial chemistry.
Who should find it valuable?
The course assumes no prior specific knowledge of pharmacology, but aims to convey the unique flavour of the subject and its relationships to other branches of the biomedical sciences. It will be especially useful to those in allied fields who would like to gain an overview of the problems, approaches and methods of particular concern to the modern pharmacologist.
Programme
Emerging and reemerging infections: the epidemiology of the challenge
· Recent trends in infectious disease
· Socioeconomic factors
· Changes in medical practice
· Drug resistance
· Extrapolations, prognostications
· Climate change
· Old friends, new enemies
Viral enzymes as drug targets
· Principles of selective toxicity as applied to viruses
· Classes of viral enzymes
· Nucleic acid polymerases and their inhibitors
· Proteases and their inhibitors
· Glycosidases and their inhibitors
· Other enzymes as potential targets
Breaking and entering: interactions between pathogens and their cellular receptors
· Virus attachment proteins and cellular receptors (e.g. HIV, flu, Dengue)
· Specificity, affinity and kinetics
· Cellular attachment and invasion by bacteria (*e.g. Salmonella,Mycobacterium, Listeria)
· Pathogens as cat burglars
· Installing better security
Drug resistance: the Red Queen's challenge
· The beta-lactam paradigm: a constant battle
· The biochemical basis for resistance
· The power of selection
· Cross-resistance and compensating susceptibility
· A battle won, the war to be decided: the story of HIV
New approaches to antibiotic discovery
· Basic principles of antibiotic action - selective toxicity
· Finding new targets for antibiotics to work on?
· High throughput screening
· "Gene-to-Screen" vs. "Active-to-Target" approaches
· Lead compound optimization
Effector mechanisms in immunity to pathogens
· Kinetics and quality of immune responses (Strep vs Mycobactrium; Flu vs HIV)
· Non-adaptive immunity (neutrophils, macrophages, NK cells)
· Humoral vs Cellular immunity: antigen recognition
· Neutralization and opsonization by antibody
· Cytolysis by killer T cells (defence and immunopathogenesis)
· Cytokine-mediated effects (helper cells, macrophages)
Variation in host susceptibility
· Evidence for host variation in immune response factors
· Molecular genetics and the hunt for susceptibility genes
· MHC association in malaria and dengue infections
· Molecular basis for immune response variation
· Receptor polymorphisms
· Polymorphisms in post-entry factors
New approaches to vaccine design
· How have we developed most of our current vaccines?
· So why don’t we have a vaccine for HIV?
· What are the particular problems of developing a vaccine for HIV?
· How are these challenges being overcome?
Working smarter: combinatorial and evolutionary approaches to the discovery of antimicrobials
· Combinatorial chemistry
· SELEX
· Phage-display
· The future
Registration :
REGISTRATION FORM
Please register the following delegate for the course named below (for multiple registrations please use copies of theis form):
Course Name_____________________________________________________
Date of Course _________________Registration Fee________________________________
Title (Dr/Mr/Ms etc)_________________________________________________________
Family Name/Surname_______________________________________________________
First Name___________________________________________________________________
Position/Job Title________________________________________________________________
Organisation____________________________________________________________________
Full Mailing Address ________________________________________________________
_______________________________________________________________________
______________Post code______________Telephone____________Fax_____________
Email _____________________
Signature_________________________________
Name and Position of person authorising the booking ______________________________________________
Total amount payable_______________
( )I enclose a cheque made payable to OUDCE in £ Sterling
( )I enclose a purchase order authorisation
( )I wish to pay by Bank Transfer, please send the details
( )Please debit by VISA ( )ACCESS ( )MASTERCARD( )
Card Number _ _ _ _ _ _ _ _ _ _ _ _ _ Expriry Date _ _ _ _ _ _
Card Holders Address:__________________________________________________
Special Requirements (diet, disability etc):_________________________________________
Background: It is helpful for the course tutors to know the background of delegates; please could you provide the details listed below.
· Your main discipline (e.g. Biochemistry, Organic Chemistry, Molecular Biology, Pharmacology etc.)
__________________________________________________________
· Your background (please circle) BSc/MSc/MD/PhD
PLEASE RETURN THIS COMPLETED FORM TO RACHEL BRISTOW:
University of Oxford, CPD Centre
67 St Giles
Oxford
OX1 3LU or Fax the form to (+44) (0) 1865 288163
REGISTRATION TERMS AND CONDITIONS
Places are limited so early registration by application form is strongly recommended. This will assure a place on the conference.
Registration by Fax or Mail:
Upon request, a place on the conference can be reserved for individuals who require time to obtain authorisation and process the payment of fees. This can be done by faxing or mailing the completed and signed application form to Rachel Bristow (Fax No: +44 (0)1865 288163). Invoices will be issued immediately to those submitting application forms only.
Please note that enrolments are made on a strictly first-come first-served basis, and therefore bookings will only be confirmed after a completed application form has been received. Note also that the organisers reserve the right to refuse admission to any delegate who has not paid the registration in full before the conference starts. In the event of late bookings, payment in full will be required at the registration on the first day of the conference or it is our policy to request credit card details which will be held for three weeks before processing or until payment is received.
Those who register by mail and have not received confirmation within three weeks should call us to ensure that their application has not been mislaid. Any delegate who has not received a confirmation of registration five days prior to the scheduled date of a conference should ring the CPD Centre to confirm that the conference will convene as scheduled.
REGISTRATION FEES
The full conference fee covers tuition, notes, lunches and daytime refreshments.
PAYMENT: Payment can be made in several ways: By cheque: payable to the OUDCE in pounds sterling. By credit card: using VISA, ACCESS or MASTERCARD. We are not able to accept any other forms of credit card. By Bank Transfer: please inform us and we will send the appropriate details.
REFUND POLICY
This Programme is financially self-supporting, and it is necessary to establish a minimum enrolment in each conference. If the conference is cancelled by the organisers, registered delegates will be given as much notice as possible (normally at least 10 days prior to the conference start-date). However, our liability will be limited to the refund of the registration fees in full (without deductions). If a registration is cancelled by a delegate, full refunds of registration fees less £50 administration costs are payable for cancellations received in writing ten working days before the conference starts. After this date no fees are returnable. The organisers reserve the right to make alterations to the stated Programme and other arrangements as deemed necessary.
SUBSTITUTIONS
Registered delegates who cannot attend the conference may be substituted at any time. Please notify Rachel Bristow at the address given below as far in advance as possible, giving full details of the person who will attend in your place. A completed application form for the replacement should thereafter be faxed to the CPD Centre.
FURTHER INFORMATION: Queries about any aspects of the programme - including registration, accommodation, fees, etc. - should be referred to either:
Rachel Bristow, CPD Administrative Assistant, E-mail: rachel.bristow@conted.ox.ac.uk, Tel: +44 (0)1865 288162
Suzy Hodge, CPD Portfolio Manager E-mail: suzy.hodge@conted.ox.ac.uk, Tel: +44 (0)1865 288167
Fax: +44 (0)1865 288163
PLEASE RETURN THE REGISTRATION FORM TO RACHEL BRISTOW:
University of Oxford, CPD Centre
67 St Giles
Oxford
OX1 3LU
or Fax the completed form to the number above
Deadline for Abstracts: N/A
Email for Requests and Registration: cpdbio@contend.ox.ac.uk