Invited Speakers: David Curtis and Pak Sham
Program:
The course provides participants with an introduction to the theoretical
basis of genetic linkage analysis and the opportunity to work through
the analysis of example data sets, gaining experience of the standard
programs used to carry out linkage analysis and methods of enhancing the
efficiency and robustness of data management. It is suitable for doctors
and molecular biologists wishing to gain a basic understanding of these
topics.
Course trainers
Dave Curtis is a consultant and honorary senior lecturer in the
Department of Psychological Medicine at St Bartholomew's and Royal
London School of Medicine and Dentistry. Pak Sham is a senior lecturer
in the Departments of Biostatistics and Computing and Psychological
Medicine at the Institute of Psychiatry. Together and separately they
have considerable experience of supervising the analysis of many
different diseases, and they have developed a variety of innovative
methods of analysis, including the programs ERPA, CLUMP, ETDT and
MFLINK.
Venue
The course will take place in the computer teaching laboratory of the
Robin Brook Centre in St Bartholomew's Hospital, in the heart of the
City of London. Numbers will be strictly limited to 16 participants,
ensuring that no more than two people will share each PC. Course notes
are provided as hard copy and can also be browsed on screen, and
exercises can be demonstrated using a screen projector.
Content
The practical exercises cover the following topics: Carrying out
two-point analysis using MLINK; use of LINKAGE utility programs; use of
TABLE, QDB and DOLINK to manage data and analyses; performing multipoint
analysis with LINKMAP and VITESSE; lod score analysis of a non-Mendelian
disease and use of liability classes.
Theoretical seminars cover the following topics: Overview of approaches
to gene-mapping; biological basis of linkage and explanation of
associated statistics; two-point and multipoint analysis; use of
parametric and non-parametric methods for analysis of non-Mendelian
disorders; methods based on detection of association and linkage
disequilibrium.
Registration
Course fee of #280, including tuition, notes and lunch, is payable to
Queen Mary & Westfield College (Psychiatry) and should be sent to Ann
Tyrrell at Academic Dept Psychological Medicine, Alexandra Wing, Turner
Street, London E1 2AD. Please also include a brief note about
your previous experience and current interests. Requests for further
information can be made to dcurtis@hgmp.mrc.ac.uk or
p.sham@iop.bpmf.ac.uk.
Registration :
280 UKP
Deadline for Abstracts: 28/1/99
Email for Requests and Registration: dcurtis@hgmp.mrc.ac.uk