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Introductory course in genetic linkage analysis

St Bartholomew's and the Royal London School of Medicine and Dentistry , St Bartholomew's Hospital, London
11/9/97-12/9/97

Invited Speakers: Pak Sham

Program:
The course provides participants with an introduction to the theoretical basis of genetic linkage analysis and the opportunity to work through the analysis of example data sets, gaining experience of the standard programs used to carry out linkage analysis and methods of enhancing the efficiency and robustness of data management.

The course is suitable for doctors and molecular biologists wishing to gain an understanding of the basic principles and techniques of linkage analysis.

Course trainers

Dave Curtis is a consultant and honorary senior lecturer in the Department of Psychological Medicine at St Bartholomew's and the Royal London School of Medicine and Dentistry.

Pak Sham is a senior lecturer in the Departments of Biostatistics and Computing and Psychological Medicine at the Institute of Psychiatry.

Together and separately they have considerable experience of supervising the analysis of many different diseases, and they have developed a variety of innovative methods of analysis, including the proograms ERPA, CLUMP, ETDT and MFLINK.

Venue

The course will take place in the computer teaching laboratory of the Robin Brook Centre in St Bartholomew's Hospital, in the heart of the City of London. Numbers will be strictly limited to 16 participants, ensuring that no more than two people will share each PC. Course notes are provided as hard copy and can also be browsed on screen.

Content

The practical exercises cover the following topics:

Carrying out two-point analysis using MLINK; use of LINKAGE utility programs; use of TABLE, QDB and DOLINK to manage data and analyses; performing multipoint analysis with LINKMAP and VITESSE; lod score analysis of a non-Mendelian disease and use of liability classes.

Theoretical seminars will cover the following topics:

Overview of approaches to gene-mapping; biological basis of linkage and explanation of associated statistics; two-point and multipoint analysis; use of parametric and non-parametric methods of analysis of non-Mendelian disorders; methods based on detection of association and linkage disequilibrium.

Registration :
240 UKP
To: Ann Tyrrell, Academic Dept Psychological Medicine, Alexandra Wing, Turner Street, E1 2AD - +44 171 377 7344

Deadline for Abstracts: None

Email for Requests and Registration: dcurtis@hgmp.mrc.ac.uk


Posted by: Dave Curtis Host: A212.ds.ulcc.ac.uk date: July 30, 97 7:48:13
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