Invited Speakers: Dr. P. Aebischer (Switzerland) Dr. J. Beckmann (France)
Dr. A. Berns (The Netherlands) Dr. E. Boncinelli (Italy)
Dr. H. Bujard (Germany) Dr. S. Chang (USA) Dr. O. Danos
(France) Dr. J. Dick (Canada) Prof. R. Dulbecco (Italy)
Dr. R. Fariello (USA) Dr. G. Finocchiaro (Italy) Dr. S.
Karlsson (Sweden) Dr. J. Leiden (USA) Dr. L. Leinwand (USA)
Dr. T. Monaco (UK) Dr. G. Nabel (USA) Dr. L. Naldini (USA)
Dr. L. Notarangelo (Italy) Dr. G. Parmiani (Italy) Dr. N.
Somia (USA) Dr. I. Verma (USA) Dr. A. Vescovi (Canada) Dr.
M. Weitzman (USA)
Program:
First day - 13th September 1997
14.00-17.00 Arrivals and Check in
18.00 Gene Therapy - An Overview
I. VERMA (La Jolla, U.S.A.)
20.00 Dinner
Second day - 14th September 1997
A.M.
Session Topics:
Retroviral vectors: history, general structure, production, regulatory elements, results in vitro and in animals, advantages and disadvantages, HIV-based vectors, targeted retroviral vectors, future developments.
8.30 “Targeted retroviral vectors”
N. SOMIA (S. Diego, USA)
9.30 “HIV-based vectors”
L. NALDINI (S. Francisco, USA)
10.30 Coffee break
11.00 “Murine retroviral vectors for systemic gene delivery”
S. CHANG (S. Diego, USA)
12.00 “Adeno-associated virus (AAV): The virus and the vector”
M. WEITZMAN (S. Diego, USA)
13.00 Lunch
P.M.
Session Topics:
Adenoviral and Adeno-Associated Vectors: general principles and basic virology, new generation of vectors, advantages and limits, results and future perspectives
15.00 “Recent advances in adenovirus-mediated gene transfer”
J. LEIDEN (Chicago, USA)
16.00 “AAV vectors for in vivo Gene Therapy”
O. DANOS (Evry, France)
17.00 Coffee Break
17.30 “RNA-based therapeutic approaches”
L. LEINWAND (Colorado, USA)
20.00 Dinner
Third day - 15th September 1997
A.M.
Session Topics:
Stem cells
9.00 “Development of human stem cell assays to assess gene therapy procedures”
J. DICK (Toronto, Canada)
10.00 “Development of gene therapy for hematopoietic stem cells”
S. KARLSSON (Lund, Sweden)
11.00 Coffee break
11.30 “Homeobox Genes in Brain Development”
E. BONCINELLI (Milan, Italy)
12.30 Lunch
P.M.
15.00-18.00 POSTER SESSION (including coffee break)
Evening Session Topic:
Gene expression controls
18.00 “Tetracycline-mediated, quantitative and tissue-specific control of gene activities ”
H. BUJARD (Heidelberg, Germany)
20.00 Dinner
Fourth day - 16th September 1997
A.M.
Session Topics:
Animal Models
Human diseases: targets for gene therapy
8.30 “Transgenic Mouse Models”
A. BERNS (Amsterdam, The Netherlands)
9.30 “Human genetics:from monogenic to polygenic diseases”
A. MONACO (Oxford, UK)
10.30 Coffee break
11.00 “Positional cloning and beyond: the limb girdle muscular dystrophies”
J. BECKMANN (Evry, France)
12.00 “Gene therapy for degenerative nervous diseases”
R. FARIELLO (Pennsylvania, USA)
13.00 Lunch
P.M.
Session Topics:
Neurology
15.00 “Stem cells of the embryonic and adult mammalian central nervous system”
A. VESCOVI (Calgary, Canada)
16.00 “Gene therapy for neurological diseases”
P. AEBISCHER (Lausanne, Switzerland)
17.00 Coffee Break
17.30 “Suicide genes and cytokines for gene therapy of malignant gliomas”
G. FINOCCHIARO (Milan, Italy)
Fifth day - 17th September 1997
A.M.
Session topic:
Clinical Trials
9.00 “Gene therapy vs. other innovative approaches in the treatment of primary immune deficiencies”
L. NOTARANGELO (Brescia, Italy)
10.00 “Immunological Approach To Gene Therapy Of Human Melanoma”
G. PARMIANI (Milan, Italy)
11.00 Coffee Break
11.30 “Gene therapy for AIDS”
G. NABEL (Ann Arbor, USA)
12.30 Lunch
P.M.
Social Events
Sixth day - 18th September 1997
A.M.
Session Topics:
Ethical Issues
Safety issues
The Future of Gene Therapy
8.30 “An Overview of Clinical Trials”
C. BORDIGNON (Milan, Italy)
9.30 “Title to be Defined”
G. GERIN (UNESCO)
10.30 Coffee break
11.00 “The Future of Gene Therapy”
R. DULBECCO (Milan, Italy)
12.00 Final Discussion and comments on the Course
At the end of every session there will be a general discussion on the topics. In addition, the Course is organized in such a way that participants will rotate among lecturers during meals.
Registration :
Course Fees and Grants
· The Course Fee is 800 DM, which covers all accomodation
and meals.
· There are 20 Youth Travel Fund (YTF) Grants available from FEBS for non-Italian applicants. To check your eligibility for a YTF grant please see FEBS Advanced Courses.
Application
70 participants will be permitted. The organisers will
select the participants on the basis of their application.
The deadline for applications is 30 June 1997. Successful
applicants will be notified of their admission to the
Course by 15 July 1997.
Deadline for Abstracts: 07/30/97
Email for Requests and Registration: bevan@itba.mi.cnr.it