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registry of biomedical companies

  June 30, 2022
promoting the transfer of scientific know-how between industry and academia
Registry of biomedical companies:

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Senior Integrated Projects Programme
Kalamazoo MI USA 49006
Toll free: 604-941-9022

Phone: +6049458408
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Est. 1979 at SFU (Burnaby campus) in British Columbia in Canada.

First noted either as the Undergraduate Senior Independent/Individualized Project (SIP) programme and now in 2022 as an Integrated Project programme within fields.

The project was originally titled: "Synthesis of 13C-26 Lanosterol." It was an earlier attempt to make enough substrate to feed to yeast and recovery material to assess whether end-methylation of the C-26 carbon of Lanosterol was from above or below the plane of the intermediate of the methylating enzyme.

Spin-offs have in the second decade of 2000 been derived with great value to science and are:

1. Cis-trans isomers for long fatty acid molecules and modifying their relative m.p. qualities as food-grade substances for incorporation into dairy creamed products from fat. The cis/cis, omega-3/omega-6 polyunsaturated fatty acids from oil grains is a desired product upon purification (e. g. from food-grade distillation, prep liquid-liquid chromatography). To our knowledge cos. in Canada have now taken advantage to start exploiting these new discoveries.

2. Hydride as a chemical reactive for piloting the synthesis of biokerosene (C-8) from raw fibre or methane using acetate as an intermediate.

3. Hydride as a chemical reactive for piloting the chemsafe in a designed plant in the Arctic regions in case of flame-up from toxic gases to make heavy-duty, hi-density vamp material for various covering applications including airport taxi-ways and aprons.

4. Pro-vitamin D drug candidate from Lanosteral as a precursor to making cholesterol-like intermediate and synthesis to vitamin D analogue to "gently" up the titre of active vitamin D in vivo for supportive health therapeutics.

5. The original problem to use 13C-26-Lanosterol (not made originally but stopped at 13C-26-Lanosteral in 1980 with a projected one-pot rxn for reducing the alpha-beta unsaturated aldehyde group discovered several decades later in NSW Australia) that had been 2H exchanged for 3H (tritiated) with energetic deshielding making for an upfield shift in the 13C-26 NMR peak of the quaternary 13C-26 center resulting from bottom side attack by the incoming methyl group. 


PHD Scholastic Brokering Projects:

1. Meat Science: microbiology and biochemistry and nutritional physiology. Feeding over-producing DYC with HIS, ARG and LEU together and/or grown seagrasses botanically derived and horticulturally raised with HIS, ARG and LEU and LYC as EAA/NEAA=TAA background supplements. Rates of amino acid synthesis including study of the mTOR receptor of skeletal muscle will be studied physiologically including productive output parameters.

2. Agri-plastics and Solid Substrate Fermentation. PNA-B12 and PNA-Auxin biologics for continuous fermentation culture of lactic acid that is collected by wet state dowstreaming filtration for polylactic acid, PLA, synthesis, a leading bioplastic polymer in industrial plastics manufacturing. Also, bunker siloes will be experimental with for sealment and use of clipping, an improved process to revolutionize silage-making further in this country. (Cf. Agassiz, one of BC's agri-food research stations for dairy livestock).

3. Modeling Rumen Mixing with PCS PNA-B12 Technology: Mixing Rumen Contents Across Compartments or "Pools". Defined here are physiological compartments between the PCS made basically of globulin entities in its ampiphilic paste of media, the fine-chemical biologic such as those based on PNA-B12 as a non-GMO probiotic, with biofilms at their surface with characteristic diffusion constants for biologicals and microbes within digest, the microbes being either casual or particle-bound to the communiting feed substrate. The aim is to define quantitatively, by mathematical modeling, the mixing process and diffusion process of solid media, through the surrounding digesta and the various biofilms in order to measure the velocities of the biologics. The PCS's communition rate, diffusion through the PCS-held biofilm, through to the mixing liquid phase of digesta, then onto the casual microbial population equilibrating between liquid phase and the solid or feed substrate phase and through its particulate's biofilm and measuring also solid substrate's communition rate.  This will be an early attempt to use proposed probes such as dyes with micro needle applicators with optical detectors opposite, in place, taking shot-by-shot microsecond photographs to visualize the mixing process through the phase (this may be easier said than done here and may take "orchestration" by AI to take successive, comprehensively meaningful measurements, in a rumen simulator Rusitec(R) (see: JW Czerkawski) with use of diffraction optics to measure rates through phases in rumen contents (viz. solid feed substrate, biofilm gelled phases and liquid phases, and microbial cell populations), for velocities and derived timed-lapse diffusion constants.  It may be that timed rates or velocities and diffusion constants in the order be over several seconds, or even in milliseconds or less helping to describe the mixing process in digesta of rumen contents.

4. Pig Feeding and Nutrition. Factors in animal welfare and wellness: a) stress with antioxidants with water hyacinth (a new "green" feed), b) heart function (glycosides with several to be studies in medicinal chemistry) with water hyacinth, and c) diseases (anti-microbial activity) with grass intake and greens (vegetables and forage). This might also be transposed to goats (in captivity) and deer (in the wild). Greetings, to the SUCA Farm Manager, and a project dealing with: "Goat Farming and Husbandry" and its viability for caprine dairy production for milk, cheese (and soap), Sitio Manga, Zamboanguita, Southern Negros Oriental.

In future, we plan to institute advances in caprine and ovine genome research to apply world-wide health management and to improved feeding and nutrition in metabolically up-regulated non-GMO goats and sheep using sublingual delivery of a gene-silencing biologic to be developed using PNA-B12 technology for livestock, originally from microbial fermentation food technology. 

5. Botanical and Horticultural Production of Seagrasses (a growing trend to be with vertical farming technology and fish salmonid farming together with microbial biotechnology). Calli culture and production, over production of HIS, ARG and LEU with feeding of AA supplementation (e. g. DYC), and the biochemistry documentation and further selection via protoplast fusion. 

(c) 1979-2050. Skye Blue Internet. Port Coquitlam, BC Canada.

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Last update of this entry: June 26, 2022

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