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Perspectives for Developmental Biology & Physiology: to establish the basis with Cell Molecular Biology
The use of a unified approach in Developmental Biology or Physiology at the cellular level to undertake the understanding of the basis of all cellular phenomena from the: cell's life span and longevity; cellular repair and remission from diseased states; growth and development, energetics, efficiency and productivity; and activatable states for therapeutic applications (e. g. anti-viral therapies) is becoming a reality.
Research Areas we are pursuing that are sourced from our own experiments and the scientific literature:
- Models to study are cell activatable therapeutics (CATs) and the immune system using experimental sheep modeling (e. g. a novel schema for neuro-immunotargeting cancers).
- The lower molecular weight [LMW] proteome and new pharma to discover with musco-regulatory factors (MRFs) and muscle tissue development and regulation for productive end products and health.
- The use of lithium and umbilical cord blood cells to restore function in chronic complete spinal cord injury.
- Speculation for a role with energy efficiency utilization at the cellular level and the role of p38 and tissue necrotic factors alpha (TNF-alpha) and mitogenesis and longevity or lifespan. There is research continuing in this area at the Medical Faculty, UNSW, Sydney, Australia NSW 2033.
- VitD and fructan and their interactions with p38 and their role in modulating the low-intensity, chronic inflammatory response as it impacts disease states such as: atherosclerosis, T2Diabetes, hypertension, and multiple sclerosis with new pharma to be discovered.
- Fructan and APPs and their role in determining the efficiency of microbial biomass turnover in the ungulate stomach; this as a model has also applications to efficiency in productivity of farming animals and should be of interest at the U. of New England, Armidale NSW (AU) 2351 in their Large Animal Research Unit (LARU) for energetics livestock research in future.
- Immunocontrol in the rumen such as with predators and enteropathogens; cell membrane and porin modeled biocontainment of probiotics in the rumen stomach using recombinant technology; and dsRNA technology with PCS delivery systems in adjuvant with feeds and rumen digestion; opening up is a dairy application with mastitic control in the boosted (GMO) or hi-producing cow's udder.
- There is a question of what therapeutic modalities, viz. including genetic counselling & therapy with stem cell transplantation therapy that will emerge from research of this vast, new area encompassing cell development & physiology and its attendant pharma especially from the mind-body axies (e. g. brain<->organosomal systems and others with interlinks) to be discovered in the analysis of the depleted plasmoidal and plasmoidal-like LMW-proteome.
Drug Discovery with Boosted Dairy Lactoferrin Using Small Molecule Biopharma for Heart Health.
It was quoted recently from a paper that, "The question that confronts the issue of manipulating dairy lactoferrin in milk in terms of composition (and as it would also follow, total output), significantly boost medicinal-conferring milk food proteins (e. g. casein, alpha-lactalbumin and lactoferrin are examples of those of interest in the scientific literature) which likely serve a protective role against chronic inflammation, is with what therapeutic drug discovery using small molecular tools can we carry our search further with?" [D. A. Flores. 2016. Editorial. Biomolecular and Medicine J. @ dannflores9. wordpress.com.] It is believed at Skye Blue that small molecular analogues to p38, a molecule that addresses the 'suite' of chronic inflammatory markers [D. A. Flores. 2013. Overview Paper. Biomolecular and Medicine J. @ dannflores7.wordpress.com], that are 'recalcitrant' to breakdown could be used therapeutically for heart-health, for example, by single amino acid residue substitutions without affecting tertiary considerations to subunit and allosteric structure or function. A so-called 'proteosis' cascade of events will kinetically determine the half-life given the avidity of binding of p38 as ligand.
Boosting Milk Proteins with Medicinal Properties for Heart Health: the Search for Transcription Factors to Caprine Lactoferrin.
The modern molecular genetics of caprine (goat) dairy function (viz. yield or output, milk content or composition,%) has advanced in recent years with finds elucidating the SNP (single nuclear polymorphisms or mutations) in DNA with chromosomal (c'somal) position (viz. their numbering). Microsatellite tracts consisting of repetitive DNA sequences with certain DNA motifs are repeated 5-50X (times) with DNA microarrays- point oligo-DNA arrays, as probes binding to cDNA or cRNA called targets that are appropriately labelled, used for fine-mapping quantitative trait loci (QTL) determinations, or how significantly a QTL point locus correlates statistically with a phenotypic parameter. However, there have been limitations from "old school" standpoints regards low resolution limited by the statistical confidence limit intervals to a certain significance level. A recent study reported by Shopen et al. (2011) [in Marcel Amills et al., 2012, Genetic Factors that Regulate Milk Protein and Lipid Composition in Goats, Intech, Chap. 1], demonstrated significant association between loci in c'somal positions: 5, 6, 11, & 14 to milk protein composition. For our purposes at Skye Blue of producing GMO goats with boosted caprine lactoferrin (cLF) milk protein for medicinal purposes, a preliminary find that points to regulatory genes (transcription factors, TFs) is a trans-effect in bovine cattle that could apply to sheep and goats of an SNP locus affecting c'some 11 &14 for alpha-casein unit one protein (a major casein protein) while residing in position c'some 6.
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Last update of this entry: May 31, 2020