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  September 24, 2016
promoting the transfer of scientific know-how between industry and academia
 
 
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ORGANISCHE BOTANIE 7

SkyeBlue Organization Office +011-778-554-6691
Malaysia
Malaysia
Toll free: +011-778-554-6691(voicemail)

Phone: +1-604-945-8408 local
Fax: +1-604-464-0103 local
Stock symbol: OBO

Description:

A Think-Tank non-profit 

  •       Marine Botanicals
  •       Organo Drug Discovery and Biopharmaceutica
  •       Phytobotanics

We would like to refer the viewer to websites discussing this far-ranging topic including:  MEDBIOS (formerly: Bio-Pharmacor), and VITRIA (at hum-molgen.de).

We research, further develop and initiate discovery of phyto-based nutritionals in both maintaining wellness as well as protecting and even reversing diseased conditions.  There may be more pharmacopoeia to be mined and discovered in metabolomics and genomics of nutritionals and the genetic variance and response from these nutritionals.  Complementary medicine with its alternative phyto-therapeutics and the application in the area of fitness, nutrition and gerontology with the aging population with drugs that support the mind-body axis and wellness is being investigated.

The 'phytosome' of phytobotanics should offer a new window revealing 'primordial events' and 'stages' with animal genomics as to the process of cell programming towards cell growth, differentiation, proliferation, development and apoptosis.  Future bioinformatics should be aimed at these problems. In a futurescape including advanced organ transplant donation will require insights into primordial stem cells and their differentiation into various tissues, with cell signaling, cell migration and the assembly pre-partum/post-partum of different <organosomes> and perhaps in progressive assembly into a succeeding life form.  This is of course pure speculation at this time as to the nature of the whole body <metasome> and its <plasticity> in terms of the predicted variegation, interactions, and degrees of development and assembly of sequence and their intra- and inter-cellular factors.  

As for phytobotanicals such as for cosmetics, prebiotics for crops, neuropharmaceuticals and functional foods, these present other prospects for these agents. There will continue to have flora/fauna sourcing of possible drug agents.  We would like to present to the viewer the prospect that only a few as is the rule rather than many are ideal drug targets for use in medicine.  A new anaesthetic that is more effective than morphine has been identified from its animal source as an example.  The rainforests are to be in our opinion conserved and protected and the species enumerated and cultured for their traditional medicinal ingredients including areas such as the South American Amazon and Indonesian/Malaysian, Borneo/Sarawak and from Skye Blue's own agenda the Philippine Islands. 

The task of cataloguing individual compounds will require screening in vitro with LC/MS of the cell target proteome and finding significant biomarkers with their expressed effects in vivo in animals.  The intricate metabolism and the many individual investigations of each drug target will require considerable logistical efforts by numerous scientific organizations. 

Nutritionals in terms of toxicity are to be determined that act at dosages typical as those or associated with supplements.

Drugs that we are currently investigating are: sterols and their analogues (see: our Vit. D-associated sterol analogue for MEDBIOS and Vit. D and wellness), resveratrol, associated with cruciferous vegetables (as with nutritionals the health-conferring benefits for this nutritional are multiple and probably related which, in this case, includes in experimental animals longevity, effects on sugar metabolism and insulin, inflammation and cancer, cardiovascular health, Alzheimer's and plaque formation, etc.) and flavonols for lowering blood pressure, amongst other health benefits in maintaining vascular health and controlling diabetes type II, for which we also have a synthetic schemata for.  Omega-3-fatty acids are considered implicated as anti-inflammatories and may contribute to heart and vascular health guarding against heart disease and also relieve inflammation and pain such as with Ibuprofen and Voltaren (both proprietary drug names on the market).  There is much also still to be uncovered with inflammatory response and the onset and progression of Alzheimer's disease.  A search of phytobotanicals or nutritionals should be underway for this disease and would be a 'gold mine' as a protective in the diet for earlier in life.

The means of delivery of nutritionals to the body either through organo-sources "as is" [which we are suggesting requires further fortification with genetic manipulation (GM) of metabolism of the nutritional to ensure sustained and efficacious dose-responsiveness] or by supplementation of dietary intake of organo-sources in semi-purified or purified form as has been practiced should continue to be in current use.  It is likely that there are identified multiple health factors concertedly acting on health status and that taking it at those dosages and for prolonged periods or in sustained fashion is the effective practice or means.  The "Mediterranean Diet" which combines anti-cancer cruciferous vegetables, omega-3-fatty acid oils from olive oil and fish and fibre from fruits and vegetables (and what has been uncovered recently, the complex carbohydrates or sugars such as mannose from the aloe vera plant which has gained proprietary use and fructans with multiple health effects) is one example of an "as is" dietary-delivery system.  One can speculate how most Western diets can be reconciled with such known health-promoting diets with demographic evidence showing low incidence or the absence of most modern day health-related issues of today's lifestyle.

Proprietorship and regulation of these agents found in foods and sold as nutritional drugs and their eventual deregulation are issues.

We would like to collaborate at SkyeBlue with organo-synthetic cos. in research and production of organo-synthetic nutritionals that will contribute in future with the increase in sustainability of food, address issues of shelf-life and food product lability and the extension of biopharma or supplement nutritional availability in cases of nutritional deficiencies or in event of inclement emergencies in food production and distribution.

Contact us further for your input and collaboration to address how the organo-synthetic approach can help bridge the gap between market demand and provision for these valuable commodities in future.

SKYENEWS: The NRG group at a local polytechnique in Vancouver, British Columbia, BCIT, is pioneering the interdisciplinary approach to the otherside of phytobotanicals and nutritionals, researching toxicological issues from plant sources and food safety.  They are researching plant identification, collection of flora and processing to isolate, identify and analyze further putative agents.

SKYENEWS: Research and development should continue, led by functional foods, nutritionals (including supplements, Vit. and minerals) and the "unique" in vivo pharmacopoeia to be discovered by in situ, ex vivo studies that can protect, reverse and even maintain health from the ravages of modern day occupational-related diseases, some scope offered by the low molecular weight [LMW] proteome including transcriptional factors (TFs) that control expression of cellular gene products and a wider scope found, it is believed, within the ecosphere for phytobotanical pharmacopoeia from their nature habitats, including the vast rainforests of the world (e.g. the Philippines, Borneo/Sarawak, Brazil).

SKYENEWS: Discovery of drug targets at Skye Blue from the possibilities of drug discovery with the duality of Vit D and inulins (fructans) on atherosclerosis, diabetes and colon cancer has been suggested for physiological assay methods or protocols as follows.  TF activation or expression with cell systems should be assayed using the OATFA system and their associated gene products (i. e. enzymes, structural proteins, transport proteins, etc.) characterized from a molecular biological standpoint in order to discover and characterize targets for drugs.  Drug design in tandem with X-ray crystallographic/cryo-transmission electron microscopic studies and synthesis and clinical trials will eventually follow.  It was stipulated that although drugs would target molecules involved with specific non-immunogeneic response so as not to lower below the norm, that drugs perhaps affect other specific functions affecting inflammation in some other way.  (Note: there are assays to assess immune system status such as T cells, macrophages and cytokines in test animals in the site of infection.)

SKYENEWS: Earlier we referred to the use of functional foods and their delivery to the general population such as: PUFAs [oleo-margarines which may be liquid at room temperature (degrees C), patent pending in U.S.A.] then kneaded into breads (the French and their Boulangeries or bake shops are notorious for the varietous) with a pump dispenser (patent pending in U.S.A.), a nifty idea, when producing breads in a sink-bowl with drain (patent pending in U.S.A.) before setting to rise, in addition to use when making gravies, mayonnaise, sour cream, youghurt, cream cheese, salad dressings, as the list just goes on and on. The application of inulin in both "as is" fruit & veggies. And supplements with VitD precursors to both prevent chronic inflammation and eventual long term health problems that are cardionemic, relating to T2Diabetes, and cancers including the colon.    

SKYENEWS: What wonders 'Pinoy' (Filipino) phytopharma can offer from our plethora of forests, orchards, farms and fields and its native flora.  We'll be sure to work away as to what ingredients (e. g. Annonaceous acetogenins) have been thus researched in the much loved and luscious guayabano fruit - and their 'tea leaves', that controls the inflammation response, as has been found with fructan and Vit D and what perspectives this offers in terms of small organic molecules and drugs in molecular medicine. 

SKYENEWS: Plantation farming is catching on in the Philippines and the farming of coco sugar based on the influorescence (flowers) and stems and leaves of the coconut tree collected of its sugared tree sap in the tropics and also of maple trees for sap for maple syrup in temperate zones, should be genetically manipulated (GM) for boosted sugar production from a sustainable standpoint of tree-bearing saps, as tillable farm lands become scarcer and the need to grow adaptable, hardy tree spp. in marginal or traditional plantation lands also further adaptable for mixed (plant-animal livestock) farming offering perspectives in their synergy between them. The attractiveness commercially of the functional food of coco sugar is that it offers a low glycaemic index suited for diabetics and shows an investigatable functional profile of: higher levels in minerals: potassium, phosphorous, magnesium and iron and zinc (implicated in glucose uptake) and contains Vit B1, B2, B3 & B6 and 16 different amino acids of which glutamine is highest; in terms of sugar management in diabetes these profile factors should be taken into account and further investigated. Maple syrup and/or sugar will become more attractive as a product and one suitable as an export-grade product from countries like Canada.

SKYENEWS: Wondering what the next 'Pinoy' cafe latte will be? Brew some fine Nescafe coffee then add the remaining soya milk or creme from cows milk, coco sugar (low glycaemic index for diabetics) (also, similarly glycaemic load, GL) from the coconut palm's collected sap, stir in an anti-cancer fighting acetogenous tea extract from the sour sop fresh tea leaves and finally add the secret ingredient of our proprietary oleo L-fat from home-spun, partially hydrolyzed olive oil for an extra delicate richness that will blend in with the creme atop and stir in an extra touch of the signature leaf design, with our compliments. Our proprietary oleo L-fat sales will balloon to several millions of dollars in the international market this year once our project is slated! Several processing formulations may be involved for each possible product application for the market (see: above). [Note: the theory behind fat burning when adding 'fat' to coffee, containing caffeine, is that fat would be a part of, then taking into effect "catalysis" of excess fat burning from the release of stress hormones (e. g. norepinephrine, adrenalin) in response to the stimulant entering the bloodstream when drinking coffee, as in a "flight or fight" response mechanism.]

SKYENEWS: There are reports out that since the 'Stone Age' or invention of the wheel  with transgenesis of genes first with worms and now with plants like coffee, one, as the promotions claim, that coffee can be taken from pest-free beans that are GMO. This is the first news of food-grade vegetable food material, in this case, extracted for drink, being modified genetically by recombinant means, second only to the precedent with corn (and a few other cases, especially in developing, tropical countries merits such measures); at SkyeBlue we are recommending at this time (see: Vitria Nutri-Health Food Cos.) the GMO production of grapefruit as a breakfast drink or appetizer with boosted fructan as a hypotoniciade, hypoglycaemic and hypocholesterolaemic aide taken for breakfast, during exercise or for a snack or any occasion.

SKYENEWS: The use of low GL acidic foods sugars to cuisine, as with Filipino cookery, include now coco sugar (coconut tree sap), citrus (ascorbic acid, citric acid) and vineagre. It has not been proven how these foods act definitively to spare glucose load in the body vis-a-vis tolerance/uptake as a preventative measure against glucose intolerance with T2Diabetes. So foods such as coco honey-lemon juice-vineagre as a early morning toddy or in a B-B-Q sauce and other common everyday foods palatable to the Filipino diet including the addition to fish smelt.   

There is now a growing field exploring possible relationships between nutrient intake and genetic variation in response to them and the effect of nutritionals on genetic expression such as functional foods and, in this case, as feed additives. 

At Skye Blue we are interested in exploring anabolic signaling and effects on growth and body composition and quantitative trait loci (QTLs) mapping and fine-mapping with single nuclear polymorphisms (SNPs). There are studies relating birth weight, yearling weight, hot body weight, retail product yield, longissimus area, marbling score and back fat thickness with QTLs and their chromosomal locations. 

The use of feed enzyme treatments in studies where anabolic signaling markers can be related to explain growth and body composition response to increased nutrient inputs from treatments, e. g. ensilage with enzyme additions and improvement in digestible energy (DE) and metabolizable energy (ME), organic matter intake (OMI) and flow of duodenal amino acids (DAAs) with microbial and feed bypass fractions. It remains to be seen if there is scope in the identification, characterization and enumeration of markers in anabolic signaling at this time as this is still a field in its infancy. 

A note on QTLs: Large herd backcrosses with only one genotype resulting are performed and traits measured or assayed for each group with the genetic markers which indicates both the location and effect of the marker on the phenotype. A t-statistic is derived by an analysis of variance (ANOVA) to compare averages between groups. The QTL is usually not in the gene itself but a closely located or related marker. The markers are variable sequences of DNA identified by the researcher who eventually locates the marker near an allele on a chromosomal number in offspring related or responsible for phenotypic traits. Genes may later be bracketed as candidates, after sequencing DNA, including their specific SNPs (i. e. single base mutations) of interest to the particular effect on the phenotypic trait.

 

An AVIDEON Co. 



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Last update of this entry: September 04, 2016

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