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An SBO Company
In the field of GMO Technologies there are these possibilities: (1) basic research in biomedicine (R&D), (2) therapeutics in healthcare and pharma, (3) animal feeds, food, energy or biofuels and environmental remediation and (4) bioengineering (polymers like IBPN and ICE fermentation with a temperate or cold-adapted polar type microbiome; see: scientific literature).
To mitigate the movements against GMO type technologies, especially the food supply at SkyeBlue, we are using the following approaches: 1) plant cropping using GEdited with crossbacking using protoplasmic fusion which we are exclusively announcing here at SkyeBlue, 2) energy biocrops that are also GEdited with crossbacking using protoplasmic fusion but are biosafely protected from pollination specifically in the case of marine grasses (XL - variety) (and solving this problem involving pharma application on land cropping) with secondary plant alkaloids, 3) and food processing of foods such as polenta, higher-performing medicinal milk products and health-performing lower cholesterol eggs using cell filtration and/or DNAase treatment before packaging and storage appropriately as 'processed GMO-free', and 4) a direct-applied method in situ either in silage, per os in rumen or on the skin of animals like the mammary gland for improving silage, digestion and mastitic control, respetively using gene silencing control with protein nucleic acid (PNA) - B12 as carrier of the gene silencer.
Together with the prize-worthy method suggested above of GEditing and crossback breeding with protoplasmic fusion are the current activities of other researchers searching for significant motifs in their DNA research using modern bioinformatics.
We are also currently investigating other biomedical advances in the health fields of: mental health and aging (gerontology) and related conditions. Our approach is to help define aetiology from a developmental standpoint of both the nervous system and the rest of the body and its function in daily living.
With mRNA assays of TFs with genetic expression there is an area for drug discovery referred to, involving body weight/composition. It is proposed that tested proprietary natural extracts be used with in situ biopsy using implants/microsurgical techniques with muscle representing lean body mass (LBM), the central nervous system (CNS) hypothalamic centre for satiety and fat thermogenic tissue against a background baseline of TFs in cell tissue assays. This has predisposed us to further research implicating nutraceutical AAs like HIS (histidine) in animal livestock production in class domesticated and game animals and at various stages of their growth and development.
Approaches include future possibilities with mind-body psychoactives with putative roles of neurocrine factors in catecholamine and folate metabolism and possible roles in increased metabolic rate and health and longevity factors (the state-of-the-art in anti-aging research at this time involves approaches such as the discovery of human gene products SIRT 1-7 which control energy metabolism and cell survival which interact with nutritionals such as resveratrol in wine and with whom GlaxoSmithKline at the time of release of this story was pursuing research on efficacy trials II on more effective drug agents compared to resveratrol for diabetes type II and inflammatory disease although other diseases such as aging with cancer and heart disease are also involved; research is being investigated at the Harvard Medical School and conjointly with UNSW Medical School), biopharmaceutical mood-altering functional, cognitive enhancing and kinesiologic therapeutics with possible developmental and geriatric applications, including links between exercise therapy and the onset of dementia and neurocrine deconditioning and anti-addiction therapies.
It is enticing to think that there are now direct linkages metabolically between aging/degenerative disease states and metabolism as with the gene products mentioned above and that, as we have espoused here, use of nutritionals can be a further avenue to discover or develop drugs that can enhance longevity and/or slow the aging and its disease processes.
There are parallels seen between fructan metabolism vis-a-vis Vit D metabolism with cholesterolemia and cardiovascular health, blood sugar levels, insulinemia and colon digestive tract health including oncogeneisis and leaves open the possibility of the role of endocrine factors in metabolism. The author at Skye Blue has conducted preliminary research on lanosterol functionality and synthetic reactivity and sequencing. A proposed schema for converting lanosterol back to its C-13 labelled derivative with roughly estimated yields was presented in an undegraduate seminar discussing methodologies which were adopted from the previous literature in principle and which were further adapted using organic chemical principles by the principal research worker (see below). Further research should study reactivity of steric derivatives of lanosterol to cholesterol and study of the differential reactivity of the ring system of the sterol molecule and the discovery to how drug candidates react to metabolic targets in intestines, bone, liver and kidney. Drugs can act in feedback inhibition (FBI) as 'enzyme agonists' as analogues to Vit D as theorized.
The latest news which has again renewed the debate of inflammation (see below) and research uncovering mechanisms to diseases such as inflammation implicated with cancer and Alzheimer's is a drug that treats both skin T-cell lymphoma and Alzheimer's called by the trade name Targetrin (R) (bexarotene) that activates the surface protein and which produces ApoE which breaks down beta amyloid plaque (unlike Alzheimer's e4 allele) and improves cognitive function in mice to be tested further in human trials. Bexarotene acts by presumably activating ApoE allele variants (viz. e2 and e3 allele of which at least one is carried in 16% and 95% of the Caucasoid population, while in 27% of the population at least 1 e4 allele occurs which results in considerable debilitation in terms of onset and progression of Alzheimer's). The inflammation response by last reports is highly implicated in the onset itself of Alzheimer's. A hypothesis we are putting forth at Skye Blue of bexarotene's recent find as to a mechanism is via cell signaling pathways with cell surface receptor binding and intracellular nuclear factors [also termed transcription factors, TFs (see above)] signaling as one would be led to think involved with inflammation and that inflammation's genetic products have been directly implicated with cancer (viz. apoptosis, proliferation, angiogenesis, invasion, metastasis). The immune response, inflammation and cancer share common paths of cellular communication in terms of cell signalling implying common factors in their aetiology with the inflammation response. Genetic counselling or diagnosis and gene therapy might be called for as an interventive in at least 27% of the Caucasoid population, for example as was indicated unless, of course, other interventives are found for the disease response and its symptoms and causes.
SKYEVIEW: A new publication outlines the demand for foods in the future with complex carbohydrates reviewing new and proposed research in fortifying these plant crops (e.g. cereals, fruits and vegetables, orphaned crops as the sweet potato, bananas and cassava) and their health-conferring benefits regards inflammatory response and occupational-related diseases such as atherosclerosis, diabetes and cancers. We are publishing this new paper on the links between chronic inflammation, immunonogeneic response and disease states, such as diabetes, atherosclerosis and cancer, and their links to both nutritionals, Vit D and fructans, in the lower gut, a clue to the linkage between the two factors and other diseases also linked to the prolonged chronic elicitation or aggravation of the inflammation response. We invite editorial oversight on the investigation of the inflammation process including published/unpublished research findings on this exciting and growing field in health research.
SKYEVIEW: It has been recently speculated at SkyeBlue as to the lower gut's status as an endocrine / immuno centre protecting against onset of cancers waiting to be mined for biopharma, for e. g. bioactive peptides. We believe in exploring possibilities as evidence weighs heavily towards further speculation: VitD, fructan, and now certain milk food proteins, e. g. bovine casein and lactoferrin, have been demonstrated to protect against cancer of the lower bowel or colon (large intestines). Do they 'just so happen' to act together, we speculate, or is this an organ and system or probable 'centre', as we call it, reflecting the fact that the organ system is involved in protecting or preventing against colon and other cancers -with yet to be discovered requisite endocrine / immuno functions, protecting against and acting after its onset.
Last update of this entry: April 16, 2020