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registry of biomedical companies

 
  October 01, 2016
promoting the transfer of scientific know-how between industry and academia
 
 
Registry of biomedical companies:

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MANILLA INTERNATIONAL ASSOCIATES

SkyeBlue Organization Office +1-604-945-8408
Philippines
Philippines
Toll free: +011-778-554-6691 (voice mail)

Phone: +1-(604) 945-8408 - local
Fax: +1-(604) 464-0103 - local
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Stock symbol: MTS

Description:

We are a projected single operational unit, at this time, engaged in activities with: information collection & delivery/retrieval, media & Internet and printing & publishing manufacturing.  

SKYENEWS: The continuing controversy between the Philippine Islands (P.I.) and the Chinese mainland for projected oil resources should auger to the former's favour by leveraging it further: for trade overseas with strong trading partners, for domestic use for industrial or for commercial manufacturing, warding off further adventures into "hostile takeovers" by potential aggressors overs its economically valuable and ecological sensitive area in its archipelagical shelf. The U.S.A. has renewed and expressed its solid alliance with the P.I. on protecting its territorial rights in the area by lauching a joint military presence and exercise  (viz. in the Spratleys, etc.). A similar example where the Americans leveraged themselves well in the Iran conflict after military involvement post adhoc brought eventually a peaceful settlement in the Iran homeland and brought it back to the road to civil order and progress and over oil as a major bilateral issue with countries like the U.S. What benefits brought to the table in the Filipino-U.S.:China confrontation are yet to be realized. Talking about energy, there has been a move by the Chinese and the U.S., two of largest greenhouse gas emitters in the world to limit emission by signed agreement with other co-signators which could lighten the load towards use of fossil fuels and hunger for it making the Chinese turn to alternative sources of energy such as renewables.  The Philippines is beginning to make this a major agenda issue in its central Visayas region (Region XVIII, Negros Island Region) supplying this region's island state and neighboring cities (e. g. Dumaguete, Bais and Cebu) with geothermal, solar, and now proposed, biodiesel and biokerosene by hydroponics using land-based marine species seagrasses. We are reporting this story at http://dannnnnnflores5.wix.com/genus as it unfolds.

SKYENEWS: There are rumours afoot from our end in the Vancouver area that Scottish national interests would like to take up the new challenge of approaching certain interests in the Dumaguete City area of the Philippines regards sustainable motorpediship with modular battery-driven chassis tooled for short travel in medium grade gravel roadways in local commuter networks inland around Negros region. Scottish interests will combine with Italian designers like Ferrari contracted similarly by Tata Motors of India in Cebu using a typical money source in the way of a Shanghai chinese bank facility to undertake financing throughout typical in the Philippines. Some people have rumoured that "Alcatraz" will come forth as a formative model to be seen in a Philippine-Scottish dealerships which will just be around the corner in Negros Island. Kabangkalan is rumoured to be the launching point of manufacturing of vehicular chasis and body and the motors imported from China. Job creation will be fueled with local student talent (e.g. local engineers, fabricators, labourers, etc.) and serve the growing tourist industry from Europe and N. America. The Scots have pointed out that transportation systems design is woefully lacking in a state of repair to serve growing needs including roads and bridges engineering and so with the recommendation of, e.g., containerized ferry terminal traffic with trucks and inland rail transfer. European investors/consultants will start the ball rolling with local politicos as to the political, economic and civil condition of the province together with their Chinese counterparts conducive the education, industrial planning and infrastructure developments and its life blood - finance and capitalization with economic development.

SKYENEWS: The current drive for pedi-power to be elevated to mass transit for commuter traffic in the Dumaguete City metro area in future using on-line and off-line routing plans will call for benefits for faster convenient travel, manoeuverability with ease of flow and less bottlenecks, less stress for navigator and traveller and lightening the load on the environment in terms of pollution and greenhouse gases. There is also less noise due to muffling of the carriage by the engine. Cost:load efficiency is low due to the 1:5 to 1:10 ratio of load:vehicle compared to a road vehicle and the comparable fuel mileage. Not to mention the maintenance upkeep of parts and the system of dealerships and fueling stations (biodiesel:electricity off the grid in NegOr). There is vehicle convenience by being 'just around the corner' as one would say and comfortability of the ride is left unsaid by the chassis and the internal environmental control system (air flow, humidity and ambiance) and fares billeted at X1/2 - X1/5 the normal going rate and depending on distance, short for commute and long for travel. Currently the issue before the city ordinance councillors is the affordability of vehicles being introduced. Electronic-trikes, as they are called, are being introduced as we speak and the daily "boundary" of USD$5 rent-to-own reached given the payment for fuel (alternative fuels are being introduced) and the rest in take-home pay is still prohibitive for the 4,500 or so vehicle operators in the city of Dumaguete in NegOr. Insurance is also being introduced to replace with service vehicles up to 4-5 years on plan. Hopefully, more creative financing schemes will make the concept pedi-car a reality including investor-owners in single or groups of vehicles together with the operator or navigator at premium cab fares at fractions offered by cabbies and jeepneys in the city, albeit, but not for longer inter-urban commutes.

SKYENEWS: The story we are covering here is the latest news on the proposed Scottish-designed McCloskey-Panganiban chassis proposed for the "Alcatraz" American motoring vehicle at its best with sleek modular design features, the so-called "concept car", with features such as: 1) swinging side door design, 2) hydraulic undercarriage steering, 3) silicone hydraulics suspension, 4) rear undercar mounted motor (to be designed and manufactured by a concern) with dual-mounted batteries and biodiesel reservoir, 5) navigator side car door design, 6) airbags in passenger cab and navigator side, 7) telemetric communicator and metereological data reporter via satellite, 8) electronics sound-display entertainment system, 9) environics control system (air flow, humidity and ambiance), 10) aircare and 11) wide 3-wheel based axel steering with suspension for the gravel graded roadways. There will be electrical-charging/biodiesel filler up stations from McCloskey-Panganiban just around the corner in urban areas with maintenance stops including car washing stations. A co-ownered relationship is believed to be the business understanding within a team of 5-10 individual investored-owners per vehicle (min.) together with the hired operator/ navigator) and car insurance coverage in case loss/damage in the face of accident, theft or vandalism to equipment or vehicle. The huge, unimaginable, prognosticatable market in the mainland of China for pedi-power commuting and travel in peri-urban and rural centres makes it an inexorable influence to adopt consultation now on the matter in the Philippine Islands when talks begin for manufacturing engine, chassis and parts and various road ammendments including stations and other facilities (government transportation & licensing, insurance, energy utilities, businesses and financial centres). Some of the advantages of pedi-commute is low-maintenance at station stops, less congested, facilitated roadway works and tourism including return trips for resorts including beaches. Export markets from the Philippines include: China/ROC, India, Sri Lanka, Bangladesh, Thailand, Cambodia, Laos, Vietnam, Indonesia, Cuba, Dominican Republic, Southern Kazakhstan (experimental).

SKYENEWS: Recently it was picked up from sources on the ground in Dumaguete City, NegOr., that there is political opposition to proposals between Scottish-Filipino interest in the "pedi-power cause affair" due to apparent viewpoints that there was little benefit to job creation and investment opportunities to benefit the poorer members of the populace, compared to the more comfortable middleclass and foreigners- who are extremely attracted to this enticing business proposition. However, recently it was announced that blocs like the socialists, the communists and even extremists (albeit not the insurgents) view this development as an effective leveraging tool to negotiate with the Chinese on oil rights in the Philippine Western Sea based on the principle of industrialization and co-op unionization and domestic oil quota assigned in addition to trading rights, refining rights and exploration. The Filipinos should be told that if there is any defense to their name on vestige of oil wealth in their country's continental shelf, any defense to the matter according to the President ("Pangulo") will lead to a blood bath unless done via settlement or agreement with the Chinese with and including the central issue of leveraging via domestic or local trade and industry initiatives including investments from foreign nationals including interests from Singapore, Australia, and the U.S.A. 

SKYENEWS: The development plans continue in the Philippines are with the following investments in: 1) knowledge-based industries & IT; 2) infrastructural, facilities and equipment capitalization; 3) and human resource development (HDR). In particular, the Dumaguete City, NegOr. area is considering spearheading tourism and ecological awareness in the area or eco-tourism as it is more widely known with the ff. in planning and development: 1) planning with public interest interest in mind, 2) probing the market and surveying, 3) developers and real estate planners, 4) upgrading plans with help of city planners and zoning of by-laws with the reward of enjoying value of upgrade over 15-25 yrs in structural durability with market conditions, and 5) geographical strengths of the locale as in transportation access, amusements or recreation, natural amusements - all under regulation by government, e. g. land owernship, professional licensing permit issuing, accreditations, etc. Granted this is a solid scheme for a plan to embark on as the Philippine continues a steeper climb for development.  

SKYENEWS: Recently the development in the British Columbian lower mainland Fraser Valley (also known as the Greater Vancouver Regional District, GVRD) of a futuristic local Life Sciences Hub north of the border of its better known cousin called Silicon Valley, San Jose CA in the U.S.A. will entail real estate development as a new lucrative growth niche market in the commercial-industrial sector attracting both foreign investment, manpower from the rest of Canada and overseas in terms of skilled labour and top-tiered world class resource management and other immigrants seeking opportunity with growing demand. Trade mutual to both G-8 class countries and developing emerging market countries and Canada will encourage further incremental growth between the two and to stem any domestic trends of back immigration and the potential risk of efflux of capital from the region, a securities exchange commission to stabilize asset holdings, viz. and the liquidity of assets.

SKYENEWS: Discussing further feed resources in rain-fed tropical farming systems in areas that have 'maxed out' farming and continued into the 'hinter' and 'uplands' there are systems  of farming suggested such as SALT and island (concentric) farming of various crops: cash (e. g. corn, tobacco), root crops, fodders (e. g. browse trees & shrubs, grasses & legumes), and fruit trees, although the question is, how does commercial farming cooperatively work with the systems previously described. It would be logical to deduce that machinery, some infrastructure  and energy resources would be invested in such an extensive venture such as SALT farming in the 'uplands'. It is assumed at this point unless commercialized that handling (e. g. harvesting, transporting, storage, marketing) would be only to points of locality. And that rather the application is to use fruit tree farming as with these 'upland' or 'island' plantational farming schema in med.-size farming as is already planned in Mozambique with certain multi-national investments in Africa for purposes of making an ROI and agrarian reform in the country. E.g.s. of fruit plantation farming would be: along with vegetables, pineapples, papaya, mangoes, guayabano, rambutans (a Chinese delicacy) and avocadoes. 

SKYENEWS: In the 'Russo Hi-Tech Mainland' (Russian territorial mainland across the Island of Sakhalin), RHTM, there are the key sectoral cities of Vladivostok, and much further north, Magadan, and on the eastern shore, Okhotsk opposite the Okhotsk Sea as a rough diagram of the vast area to settle in future for a Bio-Industry Hub including transportation supply chains (e. g. potable, hi-grade polycarboxyols, goods and services, fossil fuels including LNG) across Russia from the Far East and down to the West and Central Asian republics and also key links between the RHTM and China and Mongolia, (but perhaps except Koreas and Japan as other exceptional multi-hubs in the Far East Asia). SEAsia would consist of another more minor Bio-Industry Hub in the region due to their relative underdevelopment as 'Tiger Economies'. India or the South Asian sub-continent needs further assessment at this time including overpopulated countries around South Asia and Far East Asia before contingency with biotech and their enablement with physical infrastructure, productivity, government regulatory bodies, business and labour infrastructure and health, education, food security, housing and sanitation are first considered. There is considerable wealth in the Western Philippine Sea. Energy extracted there in future can be shared in consideration with markets in India, China, Japan, ROC, Korea and certain militarized/industrialized nations in SE Asia (e. g. Singapore, Malaysia, Thailand, and Hong Kong) and needs to be addressed. We hope the World Economic Forum (WEF), Philadelphia PA U.S.A. will conduct extensive dicussions with insiders, consultants and experts in their fields to bring about progress in developments through dialogue and action on these resolutions in the New Year - 2015 as they did in Manila in 2014, recently.  

SKYENEWS: Recent news out of Africa regards inclusive development strategies including ports, rail, airports, roads, telecommunications, food manufacturing and processing and security with trade-export, agro-development-agrarian reform, energy fingerprinting and increased use of biorenewables and security, and urban regeneration strategies. There were two of but many examples possible in achieving this goal: 1) "Enjoying healthy lifestyles in African modern living," with greater financing and promoting of preventative healthcare; 2) financing the downtown of Johannesburg via regeneration such as multicultural, commercial marketplaces as safe "civic" meeting places- only the limits of man's creativity will see to its reality: culturally as to native ethniticity and immigrant groups, commercialization in tourism-hospitality including adaptation of cuisine and service, by civic demand among locals as to their festivals/rituals not to mention outside the commercial offers of merchandise made locally by traders, dealers including precious stones and jewellery in Africa. Eventually, large-scale venues for tourism may follow in bigger cities for food, amusements, gaming, entertainment and recreation; 3) in addition we add here our story that food security would reach the two-strata "haves" and the "have-nots" of their society and with "civic resettlements" amongst the more urban poor, food will have to be channelled towards the urban areas which will be met with affordable transport or commute between outward village settlements and these places of sustainable "urban regeneration". Money in the hundreds of millions of USD$ will be made through the traditional marketplace- and beyond, known since our parents days for us who were raised in such a domestic milieu. 

We are currently working with new and promising technologies in agriculture and biotechnology including biotechnologies applied to animal production. Technologies might include in the future physical and chemical pre-treatments of forages, applications of microbial ligninolysis for feed ensilage, development of low-lignin forages and use of enzymes and fermentation to process the ligno-cellulose in fibre in feed to increase fibre digestibility, developing high-sugar forages and forages low in protease activity to decrease the degradability of protein together with partial heat damage by wilting in the field prior to ensiling or haymaking, eliminate protozoa in the rumen with anti-protozoal compounds in forage or by a previous method or approach currently being further developed using immunocontrol through the ruminal gut wall against surface protein antigens from protozoa, decrease degradability of protein in feed with protective compounds in forage and develop dual-purpose cultivars with forage high in protein and grain by developmental genetics to increase energy availability, rumen microbial protein synthesis and undegraded protein. Increasing protein supply is beneficial towards the production of wool, meat and milk which are limited by it.

Some of these technologies have already been developed or have appeared in the developmental stage and we are further promoting them for significant development towards their adoption. We also have a longstanding involvement with the application of rec-DNA techniques to modify rumen microbial digestion to boost fibrolysis (including ligninolysis) in the rumen and to increase protein synthesis via their possible synthesis with introduction of proteins introduced into hosts from foreign sources. Some of these technologies proposed as applied to crops include anaerobic ligninolysis with ensilage of rice straw, whose practice has been proposed for tropical countries, low lignin in sugarcane for this biomass crop in the bagasse and high sugar or fructan content and other water-soluble carbohydrates in sugarcane tops (the aerial part of the plant), higher protein enriched and higher protein quality in the major grains such as maize, wheat, barley, oats, rye, sorghum and millet and low-lignin content, boosted sugar or fructan content and other water-soluble carbohydrates (WSCHOs) and low-protease activity (with heat protection of harvested forage) in whole maize plant for ensilage, alfalfa and other forage crops including possibly fodder trees and shrubs used in the tropics. Genetically altered low-lignin forages such as alfalfa, tall fescue and white clover are in their beginning stages of development. Low-lignin cob corn for increased ensilage of biomass has been commercially developed. Contingency traits in the event of plant biotic (eg. insect resistance, disease resistance) and abiotic (eg. drought/salt/cold tolerance) stressors and traits affecting overall plant productivity or yield are also included and are under development at this time. Recent developments in answering to the petroleum shortfall with biofuels such as ethanol include cellulosic ethanol from construction wood waste, low-lignin cob corn, bagasse from sugarcane and another variety for energy, low-lignin sugarcane and switchgrass that grows on land that competes less with food crops, like the castor bean and miscanthus.

We are tracking these technologies for technical feasibility, cost-effectiveness, practical simplicity, cultural practice, sustainability, efficiency and overall productivity. The strategy towards technology development takes into consideration the following elements. Strategic research (basic research and technical feasibility, GMO traits and output quality targets with product concept and design and market competitiveness analysis), field research to measure yield characteristics, optimal growth conditions, farming practices or methods and safety to the environment, regulatory approval with the FDA/EPA (health and safety, environmental safety), patenting rights and licensing and commercialization of product (market competitiveness analysis, business team strategy and development, intellectual property strategy, technology licensing, linkages with industry/third stage companies, incubator space in small-scale start-ups, funding or business finance of IPOs, marketing and distribution, import/export regulatory approval, multilateral trade and agreements, process product development, engineering design and manufacture, pilot-scale mock-up and production scale-up). 

Another area of research is maximized cropping for biomass and has included corn, sorghum and sugarcane for feed and bioenergy and with low-lignin, high-WSCHO and high-crude/storage protein N in the cane variety and plantain banana as a high-starch/water-soluble carbohydrate whole plant feed source with molasses and canola or soybean meal as supplemental proteins.

Biotechnology options have been discussed in organizations world-wide and their role in technology for practical ends in animal production.  The consideration with these 'newer' biotechnologies is their use for maintaining health and to serving feed nutritional supplementation (e. g. vaccines against animal diseases and growth factors). There are other areas in feeds treatment to make available nutrients and to supplement feed, microbial agents and their efficiency with the digestive process and inbred genetically engineered variants in feeds (e. g. forages and grains) for nutritional ends as pre-biotic traits.  These are the recommendations at this time with the FAO Rome, Italy and like organizations such as the Skye Blue Organization (SBO).

 

Portfolios in Meat, Bioproducts and Engineering Research:

1. Protein Engineering.  Breakthroughs in the biotechnology of lignase-driven microbial and enzyme probiotics in feeds pretreatment en silo and in the rumen, biofermentation of biofuels (e. g. cellulosic ethanol, n-butanol and fatty acid alcohols).

2. Physics Engineering.  Gel-analyte detector, semi-automated biomedical analytical laser (Argon) for optical density (OD) densitometric light sensing with electronic detector as a micro device with proven accuracy, precision, sensitivity and specificity for PAGE electrophoresis to process biofermentation products (e.g. food and pharma).

4. Protein Engineering. a)Proteinaceous acid-stable non-ionic surfactant vesicle (NISV) - sequestered immunocontrol of lower G. I. tract diseases (e. g. diarrhoea, dysentery and cholera) with such functional food grains and other 'fruit & veg' products with IgG gut proteins. b) Immunocontrol of rumen protozoa using antigen-bearing forage as agent and the immunocontrol of lower gut diarrhoea and E. coli contamination of the lower gut and meat products. c) Ionophores that influence the production of volatile fatty acids (VFAs) towards acetate and less of propionate and result in more proteinogenesis (e. g. milk production).

5. Metabolic Engineering.  Biogas (CH4) is currently on the drawing board as a by-product of sugarcane production.  Bioengineered cellulases, sugar malabsorption, formic acid-producers and methanogens are all implicated in the metabolic and bioengineering of the Rapid Natural Gas Process (RNGP) to feed electric grids in rural areas to supplement energy requirements in sugar plant central operations using low-lignin or physically/chemically-treated bagasse pithe from sugarcane.

6. Bioinformatics in Meat Science and Sustainable Fish Production.  High-throughput screening of genetic biomarkers correlated with productive output including: growth rate, lean body mass (LBM), marbling and developmental traits of musculo-skeletal fibrillar structure and meat quality (texture and taste qualities) and genetics and breeding of desired animal livestock.

 

SKYENEWS: There was a recent demand put on the table and question for the department of fisheries and other authorities responsible for studying ecology (e. g. reefs) to explore the possibilities of advanced ultrasonar-driven or based fishing via regulated trawler in inter-island belts and in deeper ocean using home-based and collaborated foreign computer-derived technology development. For e. g. correlations with weather conditions, observations on global warming and through season, inter-island sonar fishing predicting predominant spp. and proportionates in the catch to aid and predict fishing catches and optimize their catch amounts.

SKYENEWS: The "greening" of biotechnology has finally begun with developments like: 1) genome editing (viz. food-grade gene copy, food-safe, viral-free transgenesis and future claims to mitochondrial-based recombination being biosafe from escaped germ plasm and 2) sustainability as in cropping addressing climate change, food security and malnutrition issues (viz. drought tolerance, flood tolerance, salt tolerance, pest resistance, low-lignin, hi-sugar, low-protease, yield-boosted and mineral-boosted var.).  What the issues could be developing with the Green/NDP Party in our so-called FHTM West of the Prairies should be advocated and facilitated through discussions with various commercial concerns, viz. seed cos., for food, feed and energy feedstock. (Skye Blue would like to proactively seek partnership in its low-protease cultivars for pasture and field crop improvement in beef and dairy for grazers and silage-fed animal livestock with Dow Science and Kalamazoo College.)  

SKYENEWS: Recently, it was discussed through the newswire (network video feed) that interests in the U.S. are giving the planned Russian Far East, cf.RHTM, developments in renewed investments with China partners and others invited for industrial commercial concerns as well food-land systems that are sustainable and supportive of a planned populated group in that part of the world year-round mirroring Outer Mongolia and N. China who already have commercial trading patterns in the area and pastoral land systems. No doubt, entities like the U.S. may have to consult via the USDA counterparts in the Swiss Federal republics for rural development sciences and Australia island- continent. The push to use summer-winter cycles for biomass including feedstock, cereals and produce for feeding mixed agri-livestock systems, food manufacturing and bioenergy generation and pharma and allied health life science enterprise for a high tech science like biotech is a viable option for industry for the whole region in the Russian Far East mirroring the FHTM region across the way and pave the way for greater multilateral cooperation exchange and trade across the Pacific Rim with APEC using the U.S.A. as a key player in business enterprise, capitalization and trading platform.

SKYENEWS: The World Economic Forum (WEF) should start discussion on possible initiatives on the former Soviet Far East and energy production towards developing the region where it has been pointed out at Skye Blue that issues with: 1) special interest groups (viz. 'green' environmental groups; indigenous peoples), and 2) sustainability with alternative energy sources (both fossil and non-fossil fuels) seems not to caution developers, both State and private, and eventual harnessing of biomass farm wastes from planted and raised land-food systems (LFDS) in rural and urban regions with Bio-Hubbed Life Science company industries including Biotech Life Science (Agriculture, Food, Health, Energy, Biomaterials). Their systems in this RHTM region (see: KOMPAS Web Outlets Media, Hum-Molgen.de) is in contrast to regulated and even blocked pipelines/tanker transport and use of the "alternative options agenda" in energy sourcing characteristic of the Lower Fraser Mainland of BC (FHTM, see: Skye Blue Organization, Hum-Molgen.de) in Canada.                 

                                                                                                                                   

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