HUM-MOLGEN DIAGnostics/Clinical Research

9/10/96

Darier's disease, a dominant skin disorder

Hello there, I am working on Darier's disease, a dominant skin disorder. I am attempting to positionally clone the gene that causes this disease (on chr12q24). My latest piece of work involves cDNA selection. My request for this is a collaboration with anybody who could provide me with a human adult epidermal cDNA library, preferably one that has been prepared from random hexamer generated cDNA. If anyone can help me with this it would be much appreciated as there seems to be a shortage of good commercial skin derived libraries.

Thank you in advance for your help

Nick Jacobsen.

Institute of Medical Genetics,

U.W.C.M.,

Heath Park,

Cardiff, CF4 4XN

jacobsen@cardiff.ac.uk (Nick Jacobsen)