HUM-MOLGEN DIAGnostics/Clinical Research

30 March 1998
Unusual twins 

Dear Colleagues,

We recently had the opportunity to find the following abnormalities in an apparently monochorional diamniotic twin pregnancy of a 25 years old para II gravida III woman with no familial history of disease or malformations or

Twin A: Sacral agenesis, sirenomelia ( single median femur, short tibia, absent foot ) omphalocele, left amelia, left lung hypoplasia/ agenesis

Twin B: normal The pregnancy is now 19 weeks.

The family does not want to do karyotype. This constellation of synptoms remind us the tetrammelia with pulmonary aplasia. Has anyone the experience of such a case?


Annick Rothschild
Genetic clinic, Hadassah university hospital
Jerusalem 91120
e mail:
fax 972-2-6777499
phone 972-2-6777491