HUM-MOLGEN DIAGnostics/Clinical Research

30 January 1997
Brain Tumor in MPS

I have a 13 month old white female patient with clinical diagnosis of a storage disease - most likely Hurler, but the confirmatory labs are pending. Head MRI done for investigation of an anterior fontanelle bruit has revealed a mass lesion in the right hypothalamus/putamen and apparent empty sella.

Question: Does anyone know of any association between storage disorders particularly MPS) and brain lesions/tumors? Thanks!

Angela E. Scheuerle, M.D.
Assistant Professor
Division of Medical Genetics
Department of Pediatrics
UT Health Science Center - Houston
6431 Fannin, MSB 3.144
Houston TX 77030