2 March 1998

Dear Colleagues,

Our lab has developed reagents for mutation detection in two ion channel genes which are good candidates for inherited neurological disorders such as ataxia, absence epilepsy and dystonia, based on studies of mutant mice. We are interested in obtaining samples from suitable human families for the purpose of mutation detection in these genes. I would be grateful if individuals who have access to such families, or know where they may be obtained could contact me. We will also be willing to provide closely linked microsatellite markers to facilitate linkage analysis in suitable families.

Yours sincerely