2 March 1998
We have recently started doing linkage study on familial rectal pain in our department.
Hayden & Grossman (1959) first described a syndrome which included episodic severe pain of the submandibular, ocular and rectal areas with flushing of the surrounding skin. Autosomal dominant inheritance was apparent, and a number of families have subsequently been reported. The clinical features suggest that the cellular phenotype involves both autonomic and nociceptor neurones but the molecular basis of the disorder is entirely unknown. Intestinal 'neuronal dysplasia' has been reported on rectal biopsy in one family.
If you have any patients in your care who might be willing to participate in our study please contact us.