HUM-MOLGEN DIAGnostics/Clinical Research

17 January 1997
Noonan Syndrome and Retinoblastoma

Hi everybody,

We have seen a mother and her son with Noonan syndrome. Another sister, apparently unaffected by Noonan syndrome, has bilateral retinoblastoma. The mother is pregnant.

1. Does anybody have suggestions as to a possible connection between the two conditions ?

2. Can anybody help in prenatal diagnosis of Noonan syndrome?

3. What is the recurrence risk of sporadic retinoblastoma?

Thanks for your help.

Moshe Frydman MD
Genetics Institute
Sheba Medical Center
Tel Hashomer
Fax 972-3-5302914