HUM-MOLGEN DIAGnostics/Clinical Research

12 March 1998
Leukocyte Adhesion Deficiency trial 

Dear Colleagues,

We are currently seeking patients for a Phase I clinical gene therapy trial for Leukocyte Adhesion Deficiency.

Leukocyte Adhesion Deficiency patients contain mutations in the CD18 integrin molecule which prevent neutrophil adherence.  Patients typically present at birth with delayed umbilical cord separation, and the disease manifests itself
throughtout life with severe recurrent bacterial infections, absence of  pus at wound sites, gingivitis/periodontitis, and chronic leukocytosis.

We feel this is an exciting potential new therapy for this devasting disease.

Please feel free to contact us if you have any questions.  Thank you.

Dennis D. Hickstein, M.D. (Principal Investigator)
Associate Professor
Thomas R. Bauer, Jr, Ph.D. (Co-PI)  Acting Instructor
Department of Medicine
University of Washington
phone: 1-206-764-2705
phone: 1-206-764-2118
fax:  1-206-764-2827
Mailing address:
VA Puget Sound HCS
1660 S. Columbian Way
GMR 151
Seattle, WA  98108