12 March 1998

Dear Colleagues,

We are currently seeking patients for a Phase I clinical gene therapy trial for Leukocyte Adhesion Deficiency.

Leukocyte Adhesion Deficiency patients contain mutations in the CD18 integrin molecule which prevent neutrophil adherence.  Patients typically present at birth with delayed umbilical cord separation, and the disease manifests itself
throughtout life with severe recurrent bacterial infections, absence of  pus at wound sites, gingivitis/periodontitis, and chronic leukocytosis.

We feel this is an exciting potential new therapy for this devasting disease.

Please feel free to contact us if you have any questions.  Thank you.