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May to August 1996





The European Directory of DNA Laboratories (EDDNAL) is mainly intended for clinical geneticists and molecular biologists. It provides contact names and addresses for 280 DNA laboratories and details services on 385 genetic diseases.

The Lancet Online

Offers full text summaries of selected articles from this premiere medical journal of the United Kingdom. (Registration)

WWW Home Page | E-mail: ddunnen@ruly46.MedFac.LeidenUniv.nl


The Duchenne/Becker muscular dystrophy Data Pages

Currently, we are in the middle of setting up an Internet site for Duchenne/Becker Muscular Dystrophy (DMD/BMD). Although the site is still under construction, we believe it already contains a considerable set of information, making it worthwhile to announce it.

We hope the "Duchenne/Backer muscular dystrophy pages" will serve as an informational resource and reference point for all people involved in DMD/BMD-diagnosis. The site now displays information on: the dystrophin gene (exons, their position in the cDNA, their numbering, sizes and genomic spacing), order of markers in and around the dystrophin gene, a listing of all genomic dystrophin sequences in GenBank, Southern blotting and cDNA-hybridizations (sizes and exon content of hybridizing restriction fragments, annotated images of cDNA hybridizations), haplotyping (PCR-able CA-repeats), and a list of all known DMD/BMD (point) (including a list of polymorphisms in the dystrophin coding region and a list of primer pairs to amplify specific exons). In the near future we aim to transform the "list of DMD/BMD point mutations" into a real DMD/BMD mutation database.

The value of the pages will partly lie in researchers providing data which is not (yet) published. We hope it will stimulate many researchers to comment on the data supplied, to send updates and to submit unpublished data. Many laboratories will have valuable data sets which will never make it into print, often because of limited time and/or because the sum is considered too small to justify the effort. Please, when you have information which might be interesting to other researchers and which could be linked to these page, send it to us.

Depending on the interest in the site, the feed-back obtained and the opinions gathered, we plan to extend the site by adding more general information which should be understandable for interested non-scientific people.

Looking forward to your reactions:

Dr. Johan T. den Dunnen, (E-mail:ddunnen@ruly46.MedFac.LeidenUniv.nl)
Dr. Egbert Bakker, (E-mail:bakker@ruly46.MedFac.LeidenUniv.nl)

MGC-Dept. Human Genetics, Leiden University, LEIDEN, the Netherlands

WWW Home Page | E-mail: pcl@bestpl.hcf.jhu.edu


Community of Science MEDLINE

Try MEDLINE searching today at http://cos.gdb.org

Community of Science has developed a powerful new Web version of MEDLINE in collaboration with Johns Hopkins University. It's free of charge now during our introductory promotional period.

Please make sure your director of research and development is aware of this new World Wide Web version of MEDLINE.

Among key features:

*Linkages from MEDLINE abstracts to biological databases
*Search technology from the Human Genome Project
*Download records to leading citation management software

Community of Science
410-563-5389 (fax)

WWW Home Page | E-mail: dyann@schmidel.com

New Web Site Announcement:

The BioChemNet is a directory of selected web resources for biology and chemistry teachers. Links are organized under the following topics: General Biology, Cell Biology, Genetics, Microbiology, Immunology, Biotechnology, General Chemistry, Organic Chemistry, and Biochemistry.

WWW Home Page | E-mail: gambacorti@icil64.cilea.it

TUMORI - logo

Welcome to TUMORI OnLine (TOL)

TUMORI is the oldest Italian cancer journal.
TOL is designated to increase the knowledge and diffusion of articles published inside TUMORI.
Visitors are encouraged to send comments on the articles directly to the authours or to TOL.

TUMORI is the Official Journal of Societŕ Italiana di Cancerologia (SIC) and Associazione Italiana di Oncologia Medica (AIOM) and is property of the Istituto Nazionale per lo studio e la Cura dei Tumori (National Cancer Institute), Milan, Italy
(Franco Rilke, Director)

TOL has been prepared and is managed by Carlo Gambacorti and, from a technical point of view, by CILEA

WWW Home Page | E-mail: borsani@tigem.it

The EST Machine


- The EST Machine is a directory of links to bioinformatics resources for Expressed Sequence Tags analysis.

- This resource is maintained by Giuseppe Borsani at the Telethon Institute of Genetics and Medicine - TIGEM

WWW Home Page | E-mail: tdilling@mail.med.upenn.edu


National Cancer Institute's Physician Data Query (PDQ) statements (beta release)

OncoLink Press Release: July 23, 1996 - The University of Pennsylvania Cancer Center

We would like to inform the Internet community of the preliminary (Beta 2) release of OncoLink's hypermedia versions of the National Cancer Institute's Physician Data Query (PDQ) statements. The Hypermedia PDQ Project is supported, in part, by grants from the National Cancer Institute and the National Action Plan on Breast Cancer.

In this release, we have provided some unique enhancements to these PDQ statements, designed specifically to assist our readers:
1) Links to full abstracts for all journal articles cited.
2) hypermedia glossary of terms for the "patient-oriented" statements

For more information, point your web browser to: http://oncolink.upenn.edu/pdq_html/


The Merck Manual debuts on the Web! Access is free, although first time users must register.

WWW Home Page | E-mail: bkq@ornl.gov


Automated DNA Sequencing Newsgroup

AUTOMATED-SEQUENCING/bionet.genome.autosequencing is a moderated newsgroup for discussion and assistance on issues related to automated DNA sequencing and analysis of such fragments as microsatellites and single-strand conformational polymorphisms.
To reach any BIOSCI/bionet newsgroup via WWW http://www.bio.net/ , click on "Access the BIOSCI/bionet Newsgroups," then on the desired newsgroup. Users can read, reply to, or post new messages through the Web site if their browsers are configured properly to send e-mail.
To subscribe by e-mail from the Americas or Pacific rim, send a message to biosci-server@net.bio.net; leave the subject line blank and enter subscribe autoseq in the message body. To subscribe from Europe, Africa, or central Asia, send help in the message body to mxt@dl.ac.uk to retrieve general server-usage instructions.

WWW Home Page | E-mail: lvrebhan@weizmann.weizmann.ac.il


HotMolecBase is an easily accessible database containing informations about molecules that are thought to be involved in diseases. The informations include a list of diseases where the particular molecule is thought to be involved, the cellular functions, a list of agonists and antagonists, some key references and email addresses of contact persons. Since it is a very new site, it contains only a limited number of entries. But if you would like to contribute to it, and if you think your own molecule of interest should be included in HotMolecBase, write email to "lvrebhan@weizmann.weizmann.ac.il".

WWW Home Page | E-mail: editor@epress.com

The World Wide Web Journal of Biology is a peer-reviewed journal free to all readers.The journal features interactive molecules, movies, sound files, color graphics, 3D coordinates, links to medline from references, links to databases, resources and much more. http://epress.com/w3jbio
Lester F. Harris, PhD

WWW Home Page | E-mail: sfrye@math.upenn.edu

Anyone who has ever been touched by cancer should check out "Confronting Cancer Through Art" an online exhibition athttp://www.oncolink.upenn.edu/.

This is a unique exhibition that gives vision and voice to the experiences of all those who have confronted cancer. It includes nearly 200 works by 112 artists.

Many of the artists are cancer survivors who used their art as a means of coping with or expressing their feelings about their illness. Others created their works in response to the illness of a family member or friend.

When the University of Pennsylvania Cancer Center and the Arthur Ross Gallery put out a call for submissions, they didn't know what to expect. Because the response was so great, they expanded the exhibition to a second gallery. Still, it was not enough to accommodate all of the works that deserved to be seen. Thus, the idea for a Virtual Gallery was born.

Many of the works are also on display at the Arthur Ross and Meyerson Hall galleries on the campus of the University of Pennsylvania in Philadelphia, PA. The exhibition runs through August 25. It is free and open to the public.

WWW Home Page | E-mail: lefranc@ligm.crbm.cnrs-mop.fr


WWW: http://imgt.cnusc.fr:8104

E-mail: lefranc@ligm.crbm.cnrs-mop.fr (Marie-Paule Lefranc)

Anonymous FTP: ftp://ftp.ebi.ac.uk/pub/databases/imgt/ (LIGM-DB annotated sequences)


IMGT is an international database specializing in Immunoglobulins, T-cell receptors (LIGM-DB) and MHC molecules (MHC/HLA-DB) of all species, initiated and coordinated by Marie-Paule Lefranc, of the University Montpellier II and CNRS, Montpellier (France). IMGT is produced in collaboration between LIGM (Laboratoire d'ImmunoGénétique Moléculaire, Montpellier, France), EMBL-EBI (Hinxton, UK), IFG (Institut für Genetik, Köln, Germany), ICRF (Imperial Cancer Research Fund, London, UK) and BPRC (Biological Primate Research Centre, Rijswijk, The Netherlands).

IMGT comprises LIGM-DB (17 888 Immunoglobulin and T cell receptor sequences of which 6 804 are fully annotated, from 78 different species), MHC/HLA-DB (class I and class II Human Leucocyte Antigen alignments) and DNAPLOT (a tool for Immunoglobulin, T-cell receptor and Major Histocompatibility Complex molecules sequence analysis). LIGM-DB fully annotated sequences are also available at the EBI WWW server : http://www.ebi.ac.uk/imgt/.

WWW Home Page | E-mail: tony@COMMUNICATA.CO.UK

Welcome to Scottish Enterprise Biotechnology Group

You are invited to visit the Scottish Biotechnology Group site


the definitive site for information on Biotechnology companies in Scotland. The site provides a convenient way to disseminate current information of interest to companies, research institutions and individuals with an interest in the biotechnology industry in Scotland.

Those interested in finding potential partners for R&D, manufacture and testing within the biotechnology industry should visit this site.

If you find the site to be of interest a hypertext link to the site your site would be much appreciated.

Best regards
Tony Purcell
Communicata Limited
+44 131 662 9798

WWW Home Page | E-mail: dyann@schmidel.com

The Biotech BiblioNet

The Biotech BiblioNet (a monthly bibliography of recently published biotech articles) has been relocated to the following address:


This web site now features a search utility and direct links to online abstracts.

E-mail: hermann.graf@bmg.boehringer.com

 Welcome to OMNI

Organising Medical Networked Information

I would like to draw your attention to the OMNI project. Sue Welsh, a librarian at The National Institute for medical Research, London is guiding a collaborative effort to build a database of evaluated Internet sites providing high quality information for Medicine and Bioscience. The location and a concise summary and evaluation of the quality of the data of the sites are provided.

The address is :


The present database has some sort of British penchant but otherwise is highly recommendable as a starting point for Internet searches in the Medical / Bioscience field.

Best regards

Hermann Graf
Scientific Information
Boehringer Mannheim GmbH
Tutzing Germany

E-mail: gqva12@udcf.gla.ac.uk


SWISS-PROT should have been 10 years old in July 1996, but it may disappear on June 30, 1996

Due to funding problems, SWISS-PROT as well as PROSITE, and the ENZYME nomenclature databases will disappear on June 30, 1996 if no solution is found before that date. The ExPASy WWW server and all services associated with it will also shut down. The distribution of the SWISS- 2DPAGE database will also be discontinued. Other external databases, WWW services and software packages that depend on SWISS-PROT, PROSITE and ENZYME as well as on the links provided between biomolecular databases will also be severely affected by this problem. Users of services and databases such as ENTREZ, BLOCKS, SRS, Owl, etc. should also be aware that most annotations at the protein level available through these services originate from SWISS-PROT or PROSITE.

While the databases listed above as well as the ExPASy server are used in almost every laboratory doing molecular biology in the world, the funding for these projects has always been very modest (to say the least) and is now, due to procedural problems, going to disappear.

WWW Home Page | E-mail: hugh.griffin@bbsrc.ac.uk

A new World Wide Site entitled the PCR JUMP STATION: The site for information and links on the Polymerase Chain Reaction (PCR).
The URL is http://www.apollo.co.uk/a/pcr/
This important new Jump Station was developed in response to requests from a number of scientists (see Nature Biotechnology 1996, Vol 14, page 517). The PCR Jump Station is intended to fulfill the need for a web site containing links to accurate and up-to-date information on PCR theory, protocols, relevant computer software, PCR applications, tools, and references. The site will be of interest to many biologists, scientists, and medics. Particular relevance to molecular biology, genetics, microbiology, biochemistry, biotechnology, diagnostics, forensic science, and DNA fingerprinting.
If you know of any links that should be added please email hugh.griffin@bbsrc.ac.uk


News Editor 1.0 by Kai Garlipp.
Logo and Logo Images by Art for BioMed / Syrinx GmbH - Frankfurt / Germany.
4.0 (c) 1995-98 HUM-MOLGEN. All rights reserved. Liability and Copyright.