Location, Location, Location A drug that inhibits excitatory activity in the brain can either improve or worsen the progression of Huntington's disease (HD) depending on where on neurons its targets are located.
Arthritis is Spreading A mechanism that accounts for the spreading of arthritis between joints is presented in a study.
Re-Thinking Obesity Mutations in specific genes fully explain a small but significant subset of patients with obesity and/or type 2 diabetes while genetic factors play a key role in determining susceptibility to both disorders in the broader population.
Notch Takes a Knocking A drug that blocks a protein involved in cancer once thought 'un-blockable' has shown promise in a mouse model of leukaemia.
Heartbeat Awareness The neural pathway by which we feel stimuli originating inside our bodies -- such as our heartbeat -- is illuminated by studying an unusual patient with unique patterns of brain damage.
A Notch in Lung Arteries The common signaling molecule Notch has a role in pulmonary arterial hypertension, often caused by insufficient oxygen reaching the lungs, as reported in a study.