- The worlds biggest genetic experiment
Approval for a project to collect DNA samples from half a million Britons was given today, marking the start of the worlds largest genetic disease search.
- Hunt For DNA Amplified In Cancers Uncovers Important Target Gene
Gene amplification links growth controlling pathway from Drosophila to human cancers
- Scientists Reverse Evolution
Half-Billion-Year-Old Gene is Reconstructed from Two Descendants
- Linkage Analysis Identifies a Novel Locus for Restless Legs Syndrome on Chromosome 2q in a South Tyrolean Population Isolate
Research report of a genome-wide linkage scan of patients with Restless Legs Syndrome assessed in a population isolate of South Tyrol (Italy).
- Peters Plus Syndrome Is Caused by Mutations in B3GALTL, a Putative Glycosyltransferase
Research show that Peters Plus is a monogenic, primarily single-mutation syndrome.
- Navajo Neurohepatopathy Is Caused by a Mutation in the MPV17 Gene
Infantile, childhood, and classic forms of NNH have been described.
- New Autosomal Recessive Form of Stickler Syndrome Is Caused by a Mutation in the COL9A1 Gene
Scientists describe a family of Moroccan origin that consists of four children with Stickler syndrome, six unaffected children, and two unaffected parents who are distant relatives (fifth degree).
- Mouse Study Finds That Mutant Enzyme Is Able To Help Protect DNA From Damage
Research has shown that when DNA damage occurs, a key enzyme -- called ataxia telangiectasia mutated protein, or ATM -- becomes activated.
- Researchers Discover A Unique Pattern Of Gene Activity That Can Predict Liver Cancer Spread
Researchers have found that a unique pattern of activity for genes in cells located in the tissue surrounding a liver tumor can accurately predict whether the cancer will spread to other parts of the liver or to other parts of the body.
- Tumors Use 'Hijacking' Trick To Evade Attack By Immune Cells
Researchers have identified a potential mechanism by which tumors in mice escape attack from antitumor immune cells.
- New Findings Offer More Complete View Of Breast Cancer Gene Mutations In U.S. Population
A large study funded by the National Institutes of Health today provided the clearest picture yet of the prevalence in the U.S. population of mutations in two genes associated with an increased risk of breast cancer.
- A Potential New Target For Antidepressants
A potassium channel called TREK1 may represent a new target for antidepressant drugs.
- High-Resolution Fluorescence Imaging
Two developments, expanding the potential applications of high-resolution fluorescence imaging, are published.
- Antiviral Protein Linked To Healthier Lungs
Failure to produce enough of an antiviral protein called interferon-lambda may be linked to increased susceptibility to infection with rhinovirus - a common trigger for asthma exacerbations.
- Blocking Autoimmune Brain Inflammation
A key factor that controls the development of brain inflammation is reported in two studies.
- Feeding immunity
A link between zinc and a critical aspect of normal immune cell function is identified.
- Fighting Flies
The first comprehensive molecular analysis of aggressive behavior in any laboratory species is reported in a study.
- One Recurrent Cause Of Mental Retardation Found
Three papers describe a recurrent cause of mental retardation, which results from the deletion of a large segment of DNA from chromosome 17.
- How Neurons Sprout Like Trees
Study reveals how some neurons establish and maintain a precise tree-like pattern of dendrites, the slim projections that carry electrical signals to and from neighbouring cells.
- Protein Folding Lost In Translation
Scientists describe a new mechanism that could underlie certain neurodegenerative diseases.
- Survival Of The Well-Connected
The survival of newly formed brain cells in the adult mouse depends on the input activity they receive.