There are several freely available databases that provides detailed information about specific individual genes and proteins or that describe complex pathways or signaling systems. There is a need for a resource that provides an integrated view of both individual and systems level data.
A recent paper by Lewis Geer et al published in Nucleic Acid Research describes BioSystems, a freely available resource developed at the NCBI. Users can search by keywords and it provides detailed links from individual Genes and Proteins (Entrez Gene and Entrez Protein databases) to systems level databases, such as KEGG or Human Reactome. It also includes data from PubMed, OMIM and PubChem databases, among others.
In previous notes, I have highlighted the potential importance of the interactions between wet experimental procedures and in silico approaches. These computational resources, such as BioSystems, would lead to a more complete understanding of biological issues, going beyond the data generated by individual experiments.
Geer LY, Marchler-Bauer A, Geer RC, Han L, He J, He S, Liu C, Shi W, Bryant SH.
The NCBI BioSystems database.
Nucleic Acids Res. 2010 Jan;38(Database issue):D492-6. (Freely available full text paper)
Prof. Dr. Diego A. Forero, MD, PhD
Message posted by: Diego Forero