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Molecular Pathways in Cardiac Development and Disease

 
  June 15, 2006  
     
 


Keystone Symposia, Breckenridge, Colorado
January 22 - 27, 2007


Over the past several years, it has become increasingly clear that converging biological pathways drive embryonic cardiovascular development and adult forms of human disease. The induction of embryonic gene programs has uncovered new molecular signals for cardiac disease and potential new therapeutic targets. Developmental defects in vasculogenesis and cardiovascular lineage specification have now been linked to cardiovascular diseases that present at the adult stage. Studies of cardiovascular stem cells underscore the value of insights derived from genetic pathways guiding formation of the distinct heart lineages to identify rare post-natal heart cells and the pathways that drive their formation, renewal, maturation and triggered differentiation into diverse cardiovascular cell lineages. In short, the barriers between development and disease in the cardiovascular setting are now largely erased. This meeting will highlight cutting edge work from a wide variety of investigators with expertise in diverse fields, ranging from pediatric to adult cardiology, developmental biology and physiology, and work in multiple model systems. The topics have been chosen to feature new approaches to mine disease genes, pathways, and therapeutic strategies by rigorous study of the developmental biology of the cardiovascular system.
 
 
Organized by: Kenneth R. Chien, Eric N. Olson and Ketty Schwartz
Invited Speakers: - Timothy Aitman, MRC Clinical Sciences Centre,
- Giselle Bonne, Inserm UR 582
- Kevin Campbell, University of Iowa
- Kenneth Chien, Massachusetts General Hospital
- Stefanie Dimmeler, University of Frankfurt
- Jonathan Epstein, University of Pennsylvania
- Thomas Eschenhagen, University Medical Center Hamburg Eppendorf
- Sylvia Evans, University of California, San Diego
- Roger Hajjar, Massachusetts General Hospital
- Helen Hobbs, University of Texas Southwestern Medical Center
- Jeffrey Hubbell, Institute for Biological Engineering & Biotechnology
- Joseph Itskovitz-Eldor, Rambam Medical Centre
- Stefan Janssens, University of Leuven
- Daniel Kelly, Washington University School of Medicine
- Nils-Goran Larsson, Karolinska Institute / Novum
- Richard Lee , Harvard University
- Leslie Leinwand, University of Colorado
- Andrew Marks, Columbia University College of Physicians and Surgeons
- Elizabeth McNally, University of Chicago
- Eric Olson, University of Texas Southwestern Medical Center
- Nadia Rosenthal, European Molecular Biology Laboratory
- James Rothman, Columbia University
- Heinrich Schelbert, University of California, Los Angeles
- Michael Schneider, Baylor College of Medicine
- Ketty Schwartz, INSERM
- Deepak Srivastava, University of California, San Francisco
- Gordana Vunjak-Novakovic, Columbia University
- Masafumi Yano, Yamaguchi University
 
Deadline for Abstracts: Sept. 22, 2006
 
Registration: Please see website
E-mail: info@keystonesymposia.org
 
   
 
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