H. Lee Moffitt Cancer Center & Research Institute, Sheraton Sand Key Resort, Clearwater Beach, FL
1/25-1/28/2007
Thursday January 25th, 2007 1:00 – 7:00 p.m. Registration6:00 – 7:30 p.m. Opening Remarks/Dinner D. Gabrilovich, M.D., Ph.D., Conference Director, H. Lee Moffitt Cancer Center & Research Institute W. Dalton, M.D., Ph.D., Director and CEO, H. Lee Moffitt Cancer Center & Research Institute W.J. Pledger, Ph.D., Deputy Center Director, H. Lee Moffitt Cancer Center & Research Institute M. Foti, Ph.D., American Association of Cancer Research 8:00 – 9:40 p.m. Keynote Lecture and Session 1: Cancer Immunotherapy – Successes and Challenges Chairperson: W. Dalton, M.D., Ph.D., Director and CEO, H. Lee Moffitt Cancer Center & Research Institute Keynote Lecture Checkpoint Blockade in Cancer Immunotherapy James P. Allison, M.D, Memorial Sloan Kettering, New York Session 1: Cancer Immunotherapy – Success and Challenges A Dendritic Cell Vaccine with p53 as the Tumor Antigen for Small Cell Lung Cancer Scott Antonia, M.D., H. Lee Moffitt Cancer Center & Research Institute Tipping the Immune System Balance in Favor of Effective Anti-Cancer Therapy Elizabeth Jaffee, M.D., Johns Hopkins University, Baltimore Friday January 26th, 2007 7:00 – 7:00 p.m. Registration
7:00 – 8:00 a.m. Breakfast 8:00 – 10:00 a.m. Session 2: Antigen Presenting Cells & Immune Suppression: Mechanisms of T-cell Non-Responsiveness Chairperson: J. Mulé, Ph.D., H. Lee Moffitt Cancer Center & Research Institute Regulatory T Cells and Cancer Hy Levitsky, M.D., Johns Hopkins University, Baltimore Programming of CD+8 T Cell Tolerance Stephen Schoenberger, Ph.D., La Jolla Institute for Allergy & Immunology, San Diego The B7 Family Molecules in Cancer Evasion Lieping Chen, M.D., Ph.D., Johns Hopkins University, Baltimore T Regulatory Cells and AICD: Two Intrinsic Mechanisms for Immune Suppression Bijay Mukherji, University of Connecticut Health Center, Hartford 10:00 – 10:30 a.m. Break 10:30 – 12:30 p.m. Session 3: Dual Role of Dendritic Cells and Cancer Chairperson S. Antonia, M.D., H. Lee Moffitt Cancer Center & Research Institute T Cell Regulation by Dendritic Cells Expressing Indoleamine 2.3 Dioxygenase (IDO) Andrew Mellor, Ph.D., Medical College of Georgia, Augusta Molecular Mechanisms of Negative Signaling by Cancer Associated HPV in Immune Escape W. Martin Kast, Ph.D., University of South California, Los Angeles Antigen Presenting Cells in Human Tumor Microenvironment Weiping Zou, M.D., Ph.D., Tulane University, New Orleans Mechanisms of Dendritic Cell Dysfunction in Cancer Michael Shurin, M.D., University of Pittsburgh, Pittsburgh 12:30 – 2:00 p.m. Lunch 2:00 – 4:00 p.m. Session 4: Cellular and Molecular Mechanisms of Immune Suppression in Cancer Workshop #1 Chairperson J. Djeu, Ph.D., H. Lee Moffitt Cancer Center & Research Institute 8 speakers selected from abstracts 2:00 – 10:00 p.m. Posters 6:30 – 8:00 p.m. Dinner 8:00 – 9:30 p.m. Session 5: Cancer Immunotherapy – Successes and Challenges Chairperson V. Sondak, M.D., H. Lee Moffitt Cancer Center & Research Institute Autoimmunity and Vaccination in Melanoma Jeff Weber, M.D., Ph.D., University of Southern California, Los Angeles Dendritic Cells as Vectors and Targets in Cancer Immunotherapy Anna Karolina Palucka, M.D., Ph.D., Baylor Institute of Immunology, Dallas Saturday January 27th, 2007 7:00 – 8:00 a.m. Breakfast
8:00 – 10:00 a.m. Session 6: Immature Myeloid Suppressive Cells & Tumor Escape Chairperson M. Fishman, M.D., Ph.D., H. Lee Moffitt Cancer Center & Research Institute T-Cell Tolerance Induced by Immature Myeloid Cells Dmitry Gabrilovich, M.D., Ph.D., H. Lee Moffitt Cancer Center, Tampa Inflammatory Monocytes Induced by Tumors Alter T lymphocyte Responsiveness through L-arginine Metabolism Vincenzo Bronte, M.D., Padua University, Padua, Italy Arginine Availability Regulate the Immune Response in Cancer Patients Augusto Ochoa, M.D., Louisiana State University, New Orleans Immune Suppression and Inflammation in Tumor Progression Suzanne Ostrand-Rosenberg, Ph.D., University of Maryland, Baltimore 10:00 – 10:30 a.m. Break 10:30 – 12:30 p.m. Session 7: The Role of Tumor Microenvironment in Tumor Escape Chairperson E. Sotomayor, M.D., H. Lee Moffitt Cancer Center & Research Institute Cross-Targeting to Destroy the Tumor Microenvironment Hans Schreiber, M.D., Ph.D., University of Chicago, Chicago Expression of Indoleamine 2,3-Dioxygenase by Tumor Cells as an Immune Resistance Mechanism That Can Be Fighted Benoit Van den Eynde, M.D., Ph.D., Ludwig Institute for Cancer Research, Brussels, Belgium Human Tumor Antigens, Tumor Immunosurveillance and Tumor Escape Olivera J. Finn, Ph.D., University of Pittsburgh, Pittsburgh IDO, Cross-Presentation and Tolerance David Munn, M.D., Medical College of Georgia, Augusta 12:30 – 2:00 p.m. Lunch 2:00 – 4:00 p.m. Session 8: Cellular and Molecular Mechanisms of Immune Suppression in Cancer Workshop #2 Chairperson D. Gabrilovich, M.D., Ph.D., H. Lee Moffitt Cancer Center & Research Institute 8 speakers selected from abstracts 2:00 – 10:00 p.m. Posters 6:30 – 8:00 p.m. Dinner 8:00 – 9:30 p.m. Session 9: Cancer Immunotherapy – Successes and Challenges Chairperson A. Sloan, M.D., H. Lee Moffitt Cancer Center & Research Institute Peptide Vaccination in AML Ulrich Keilholz, M.D., Free University, Berlin Adoptive T Cell Therapy of Renal Cell Cancer Alfred Chang, M.D., University of Michigan, Ann Arbor Disruption of Regulatory Pathways to Enhance the Efficacy of Cancer Vaccines Johannes Vieweg, M.D., F.A.C.S, Duke University, Raleigh Sunday January 28th, 2007 7:00 – 8:00 a.m. Breakfast 8:00 – 10:00 p.m. Session 10: Molecular Mechanisms of Negative Signaling in Tumor Escape Chairpersons C.Anasetti, M.D. & S. Dessureault, M.D., Ph.D., H. Lee Moffitt Cancer Center & Research Institute Targeting Signaling Pathways in Antigen Presenting Cells to Overcome Tolerance to Tumor Antigens Eduardo Sotomayor, M.D., H. Lee Moffitt Cancer Center and Research Institute, Tampa Antigen Presentation Attenuators and Anti-Tumor Immunity Si-Yi Chen, M.D., Ph.D., Baylor University, Houston Cancer Immunoediting: Basic Mechanisms and Therapeutic Implications Robert Schreiber, Ph.D., University of Washington, St. Louis Promotion of a Type-1 Cell Response in Metastatic RCC Patients by SU11248; Modulation of a T Reg Population Jim Finke, Ph.D., Cleveland Clinic, Cleveland 10:00 – 10:30 a.m. Break 10:30 – 12:00 p.m. Session 11: Regulatory T Cells & Tumor Escape Chairperson R. Wiltrout, M.D., National Cancer Institute Regulatory T Cells Alexander Rudensky, Ph.D., University of Washington, Seattle
Regulatory T Cells in Cancer Tyler Curiel, M.D., M.P.H., Tulane University, New Orleans Inhibiting T Reg Activity in Tumor Bearers Mario P. Colombo, Ph.D., Istituto Nazionale Tumori, Milan, Italy Role of STAT3 in Mediating a Cross Talk between Tumor and Regulatory T Cells Hua Yu, PhD, Beckman Research Institute at City of Hope National Medical Center, Duarte 12:00 – 1:00 p.m. Lunch 1:00 – 3:00 p.m. Session 12: Round table discussion: The Mechanism of Tumor Immune Suppression and Potential Approaches to Their Targeting/Closing Remarks Participants will include representatives from biotech companies, pharmaceuticals, FDA and NCI to help expedite clinical trials that will produce meaningful benefits to cancer patients
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Invited Speakers:
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James Allison, PhD Chairman, Immunology Program David H. Koch Chair in Immunologic Studies Attending Immunologist, Department of Medicine Investigator, Howard Hughes Medical Institute Memorial Sloan-Kettering Cancer Center New York, New YorkClaudio Anasetti, MD Chief, Blood and Marrow Transplantation Program H. Lee Moffitt Cancer Center & Research Institute Tampa, Florida Scott Antonia, MD, PhD Associate Professor, Medical Oncology & Hematology Immunology Program H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida Vincenzo Bronte, MD Professor Department of Oncology and Surgical Sciences Oncology Section University of Padua Padua, Italy Alfred Chang, MD Hugh Cabot Professor of Surgery Chief, Division of Surgical Oncology University of Michigan Ann Arbor, Michigan Lieping Chen, MD, PhD Professor of Dermatology & Oncology Director of Research, Dermatology Johns Hopkins University School of Medicine Baltimore, Maryland Si-Yi Chen, MD, PhD Associate Professor Center for Cell and Gene Therapy Department of Molecular and Human Genetics Baylor College of Medicine Houston, Texas Tyler Curiel, MD, MPH The Henderson Professor of Medicine Chief, Hematology & Medical Oncology Department of Medicine Tulane University Medical School New Orleans, Louisiana Mario P. Colombo, PhD Professor and Head, Immunotherapy & Gene Therapy Unit Department of Experimental Oncology Istituto Nazionale Tumori Milano, Italy Sophie Dessureault, MD, PhD Assistant Professor Surgical Oncologist H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida Julie Djeu, PhD Garcia Chair for Leadership in Cancer Research Program Leader, Immunology Program Associate Director of Education H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida Jim Finke, PhD Professor of Molecular Medicine Department of Immunology Lerner Research Institute Cleveland Clinic Foundation Cleveland, Ohio Olivera J. Finn, PhD Professor and Chair Department of Immunology University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania Mayer Fishman, MD, PhD Assistant Professor Genitourinary Program H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida Dmitry Gabrilovich, MD, PhD Professor of Oncology, Microbiology, and Immunology Immunology Program H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida Elizabeth Jaffee, MD Dana and Albert "Cubby" Professor of Oncology Department of Oncology Sidney Kimmel Cancer Center Baltimore, Maryland W. Martin Kast, PhD Walter A. Richter Cancer Research Chair Professor of Molecular Microbiology & Immunology USC/Norris Comprehensive Cancer Center Los Angeles, California Ulrich Keilholz, MD Professor Department of Medicine III Free University of Berlin Berlin, Germany Hyam I. Levitsky, MD Professor of Oncology, Medicine and Urology Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Johns Hopkins University School of Medicine Baltimore, Maryland Alan List, PhD Professor of Oncology and Medicine Chief, Hematologic Malignancies Program H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida Andrew Mellor, PhD Professor and Director Immunotherapy Center Medical College of Georgia Augusta, Georgia Bijay Mukherji, MD Professor of Medicine University of Connecticut Health Center Farmington, Connecticut James Mulé, PhD Associate Center Director for Applied Science and Technology Michael McGillicuddy Endowed Chair Melanoma Research and Treatment H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida David Munn, MD Professor Immunotherapy Center and Department of Pediatrics Medical College of Georgia August, Georgia Augusto Ochoa, MD Professor, Pediatrics Tumor Immunology Program Stanley S. Scott Cancer Center Louisiana State University Medical Center New Orleans, Louisiana Anna Karolina Palucka, MD, PhD Investigator Michael A. E. Ramsay Chair for Cancer Immunology Research Baylor Institute for Immunology Research Dallas, Texas Suzanne Ostrand-Rosenberg, PhD Robert and Jane Meyerhoff Professor of Biochemistry University of Maryland, Baltimore County Baltimore, Maryland Alexander Rudensky, PhD Professor and Investigator Howard Hughes Medical Institute, Department of Immunology University of Washington Seattle, Washington Raoul Salup, MD Chief, Urologic Oncology James A. Haley Veterans Medical Center Tampa, Florida Stephen Schoenberger, PhD Associate Member La Jolla Institute for Allergy & Immunology San Diego, California Hans Schreiber, MD, PhD Professor Department of Pathology University of Chicago Chicago, Illinois Robert Schreiber, PhD Alumni Endowed Professor of Pathology and Immunology Professor, Molecular Microbiology Head, Siteman Comprehensive Cancer Center Immunology Program Department of Pathology and Immunology Washington University School of Medicine Michael Shurin, MD, PhD Associate Professor of Pathology and Immunology Associate Director, Clinical Immunopathology University of Pittsburgh Medical Center/Cancer Institute Pittsburgh, Pennsylvania Andrew Sloan, MD Associate Professor Director of Radiosurgery H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida Vernon Sondak, MD Professor of Surgery and Interdisciplinary Oncology Chief, Cutaneous Oncology H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida
Eduardo Sotomayor, MD Associate Professor of Oncology & Medicine Head, Lymphoma Section Division of Malignant Hematology Program and Division of Immunology H. Lee Moffitt Cancer Center & Research Institute at the University of South Florida Tampa, Florida Benoit Van den Eynde, MD, PhD Head, Tumor Immunology and Antigen Processing Group Ludwig Institute for Cancer Research Brussels, Belgium Johannes Vieweg, MD, FACS Associate Professor of Urology Associate Professor of Immunology Vice Chief of Research, Division of Urology Duke University Medical Center Durham, North Carolina Jeffrey Weber, MD, PhD Adams Professor of Medicine Molecular Microbiology and Immunology Chief, Division of Medical Oncology Keck/USC School of Medicine Associate Director for Clinical Research USC/Norris Comprehensive Cancer Center Los Angeles, California Robert H. Wiltrout, PhD Director Center for Cancer Research National Cancer Institute Bethesda, MD Weiping Zou, MD, PhD Associate Professor of Medical Immunology and Molecular Biology Section of Hematology and Oncology Tulane University Health Science Center New Orleans, Louisiana Hua Yu, PhD Professor Division of Cancer Immunotherapy and Tumor Immunology Beckman Research Institute City of Hope National Medical Center Duarte, California
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